NOAEL Studies Cosmetic Ingredient

ACETYL HEXAMETHYL INDAN NOAEL Studies

CAS: 15323-35-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5667; Record_ID=skin_sensitization_invivo_1311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9051743; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90179-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9051743
NTP_ICE_skin_sensitization Induction dose per skin area 2592 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5665; Record_ID=skin_sensitization_invivo_1311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9051743; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2592; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90179-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9051743
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=5671; Record_ID=skin_sensitization_invivo_1311; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9051743; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|Opdyke 1975; Not available; 10.1016/0015-6264(75)90179-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9051743
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7ee4b0a7c65d1c4865; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/32216/7/6/2?documentUUID=42e4243f-8a24-45c5-9dd4-106d51550cae; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|gross pathology|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15838603:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_68db922177ccce6becdc9bc76340a0f1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 3KM1212J0Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H24O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KM1212J0Y"}
openFDA substances FDA UNII substance identifier 3KM1212J0Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H24O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KM1212J0Y"}
openFDA substances FDA UNII substance identifier 3KM1212J0Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H24O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KM1212J0Y"}
openFDA substances FDA UNII substance identifier 3KM1212J0Y UNII - - - chemical {"approval_status":null,"molecular_formula":"C17H24O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"3KM1212J0Y"}