Is ACETYL HEXAMETHYL INDAN safe in cosmetics?
ACETYL HEXAMETHYL INDAN has a safety rating of "MODERATE" in our database. EU status: restricted. 1 toxicological study endpoint(s) are available in our database.
ACETYL HEXAMETHYL INDAN
Also known as: EINECS 239-360-0, UNII-3KM1212J0Y
ACETYL HEXAMETHYL INDAN (CAS 15323-35-0) is a cosmetic cosmetic ingredient functioning as Fragrance, Perfuming. NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max III/134. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 15323-35-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Perfuming
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(1,1,2,3,3,6-hexamethyl-2H-inden-5-yl)ethanone
InChIKey
VDBHOHJWUDKDRW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
III/134
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ACETYL HEXAMETHYL INDAN. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =5 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for ACETYL HEXAMETHYL INDAN across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Leave-on products (b) Rinse-off products. Max: (a) 2%.
BRIN Brazil/India Cosmetics
Brazil: Restricted · max a) 2%
India: Restricted · max (a) 2%
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for ACETYL HEXAMETHYL INDAN.
Regulatory Flags
cosing-sourced
eu-restricted
fragrance
needs-enrichment
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ACETYL HEXAMETHYL INDAN by CAS number or substance name.
Studies
1
Lowest NOAEL
5 mg/kg bw/day
Highest NOAEL
5 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
EINECS 239-360-0
UNII-3KM1212J0Y
Chemical Function
Deodorizer
Fragrance
Regulatory Lists
IFRA Transparency
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is ACETYL HEXAMETHYL INDAN allowed in the EU?
ACETYL HEXAMETHYL INDAN EU regulatory status: restricted. Maximum allowed concentration: III/134. This is based on EU Regulation 1223/2009 and its amendments.
What does ACETYL HEXAMETHYL INDAN do in cosmetics?
ACETYL HEXAMETHYL INDAN functions as: Fragrance, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 15323-35-0.
What is the NOAEL for ACETYL HEXAMETHYL INDAN?
The NOAEL (No Observed Adverse Effect Level) for ACETYL HEXAMETHYL INDAN is =5 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ACETYL HEXAMETHYL INDAN used outside cosmetics?
ACETYL HEXAMETHYL INDAN also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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