NOAEL Studies Cosmetic Ingredient

Acetyl Hexamethyl Tetralin (AHTN) NOAEL Studies

INCI: ACETYL HEXAMETHYL TETRALIN

CAS: 1506-02-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL >=20 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c1e4b0a7c65d23005f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820588_15824594:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3b709026dfc4888e6537c661df128ec
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rabbit oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce26; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823708:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_87db391c17d432034921855750351be3
ToxValDB_ECHA_IUCLID NOAEL >=50 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac00e4b0a7c65d1bce28; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/9/3?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820588_15824594:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9a1289022e93b7536da3d5d3e09bbb5e
ToxValDB_ECHA_IUCLID NOAEL >=10 mg/kg bw/day Rat dermal - subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dc67; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/4?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826867:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_327ccdc219362a9f84e66ef1f02d00f4
ToxValDB_ECHA_IUCLID NOAEL =300 ppm Rat oral short-term; 14 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cad7e4b0a7c65d223c11; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=liver: gross pathology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|organ weight; STUDY_GROUP=ECHA IUCLID:15833521:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4040ab169180e9009d10b82024f94565
ToxValDB_ECHA_IUCLID NOAEL =5 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c6270; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837428_15849277:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_702f2643102b4f54892737113be1fc62
ToxValDB_ECHA_IUCLID NOEL =1.5 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c626c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847245_15849058:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09f4c55d142a7944e12c946f40ed198f
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadd4e4b0a7c65d1c627c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/12808/7/6/2?documentUUID=403cf8b8-39ca-40c8-867d-6bba204143ae; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15849278:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5f4dfd2096eb5887b2b108829a9c9f36
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.175 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635118:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_43343abc2fda1c88f9b03739b7fef2c2
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}
openFDA substances FDA UNII substance identifier 360Q8Z01IP UNII - - - chemical {"approval_status":null,"molecular_formula":"C18H26O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"360Q8Z01IP"}