Also known as: Ethanone, 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthalenyl)-, 2'-Acetonaphthone, 5',6',7',8'-tetrahydro-3',5',5',6',8',8'-hexamethyl-, EC No.: 216-133-4, EC No.: 244-240-6, 244-240-6 (+4 more)
INCI: ACETYL HEXAMETHYL TETRALIN
Acetyl Hexamethyl Tetralin (AHTN) (CAS 1506-02-1) is a cosmetic cosmetic ingredient functioning as Masking agent (polycyclic musk fragrance). NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1506-02-1 →
Acetyl Hexamethyl Tetralin (AHTN) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H400, H410, H319, H373).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Hexamethyl Tetralin (AHTN).
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for Acetyl Hexamethyl Tetralin (AHTN). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
Pre-calculated NOAEL → SED → MoS audit trail for Acetyl Hexamethyl Tetralin (AHTN) across SCCS product categories, with measured dermal absorption where available.
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
agonist (ERα); antagonist (AR, PR)
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| Cell proliferation | ER | EC50/IC50: EC50 in uM range (low relative potency vs E2); LOEC: ~0.1 uM; NOEC: 0.01 uM mixed | agonist (significant, unlike HHCB) |
| PR-mediated transcriptional antagonism | PR | EC50/IC50: IC50 ~0.01-0.02 uM (20 nM); LOEC: 0.01 uM (10 nM); NOEC: 0.001 uM mixed | antagonist |
| Progesterone/cortisol synthesis; 3bHSD2 gene expression | steroidogenesis | EC50/IC50: Significant at >=10 uM; LOEC: 10 uM; NOEC: 1 uM mixed | inhibitor (downarrow progesterone, downarrow cortisol) |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Acetyl Hexamethyl Tetralin (AHTN).
Public NOAEL study rows linked to Acetyl Hexamethyl Tetralin (AHTN) by CAS number or substance name.
Acetyl Hexamethyl Tetralin (AHTN) has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Acetyl Hexamethyl Tetralin (AHTN) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
Acetyl Hexamethyl Tetralin (AHTN) functions as: Masking agent (polycyclic musk fragrance). It is classified as a cosmetic ingredient in our database. CAS number: 1506-02-1.
The NOAEL (No Observed Adverse Effect Level) for Acetyl Hexamethyl Tetralin (AHTN) is =15 mg/kg bw/day based on a developmental study via oral route in Rabbit. Source: ToxValDB_ECHA_IUCLID.
Acetyl Hexamethyl Tetralin (AHTN) also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Acetyl Hexamethyl Tetralin (AHTN) is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H400, H410, H319, H373).
Check Acetyl Hexamethyl Tetralin (AHTN) compliance across multiple jurisdictions:
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