NOAEL Studies
Cosmetic Ingredient
Acid Red 33 NOAEL Studies
INCI: CI 17200
CAS: 3567-66-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
SCCS Opinion 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0 | mg/kg bw | rat | oral | developmental | developmental toxicity | p.21 |
| SCCS Opinion | NOAEL | =0.18 | mg/kg | rat | oral | - | dermal absorption | p.21 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | rat | oral | 100 d | NOAEL study | Ref.: 10 B, p.12 |
| SCCS Opinion | NOAEL | =25 | mg/kg | rat | oral | - | dermal absorption | p.21 |
| SCCS Opinion | NOAEL | =102 | mg/kg bw/d | rat | oral | 18 months | NOAEL study | Ref.: 9 C, p.13 |
| SCCS Opinion | NOAEL | =102 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.20 |
| SCCS Opinion | NOAEL | =129 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.20 |
ECHA 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =181 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c81; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820445:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f300af252beb39b6046bb09d61b69b7 |
| ECHA | LOAEL | =750 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c51; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15848931:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_abc17eef26af8031575d624da098a719 |
| ECHA | NOAEL | =20 | mg/kg bw/day | Rabbit | dermal | short-term; 4 weeks | short-term | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d4be4b096bca877542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/4?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15826131:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7cf09c45bf967f877ec4d4154867450c |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac26e4b0a7c65d1bd960; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/9/3?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15821525:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e69f75d24a38f90a12f59d0a9acf21ed |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 6 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15849424:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5deaff2f37bc6b68cd56152b8e8f8b93 |
| ECHA | NOAEL | =102 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820444:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c1228f06568b39c2bda2371a3c9193cc |
| ECHA | NOAEL | =129 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c7f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820443:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fa6d2c1051fe3f9eacca668107db976a |
| ECHA | NOAEL | =150 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9ffe4b0a7c65d1b3c81; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15820446:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0d88c8627bea34457680d15e41309f21 |
| ECHA | NOAEL | =1500 | mg/kg bw/day | Mouse | dermal | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c823e4b0a7c65d216dbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/8?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15817676:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edb5bdd08dfd1cf84dd9ab6746a851dd |
| ECHA | NOAEL | =2500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae2ae4b0a7c65d1c7c46; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17285/7/6/2?documentUUID=040ee780-aff4-454e-862c-ec8bfce09ecf; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15849420:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f4038a4dbb0083f5c92a3215b39e803d |
Regulatory source 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 25 | mg/kg bw/d | rat | oral | 100 d | - | p.12 |
| Regulatory source | - | 102 | mg/kg bw/d | rat | oral | 18 months | - | p.13 |
| Regulatory source | dermal absorption | =0.18 | mg/kg | rat | oral | - | dermal absorption | p.21 |
| Regulatory source | dermal absorption | =25 | mg/kg | rat | oral | - | dermal absorption | p.21 |
| Regulatory source | developmental toxicity | 0 | mg/kg bw | rat | oral | developmental | developmental toxicity | p.21 |
| Regulatory source | developmental toxicity | 25 | mg/kg bw/d | rat | oral | developmental | developmental toxicity | p.21 |
| Regulatory source | developmental toxicity | 129 | mg/kg bw | rat | oral | developmental | developmental toxicity | p.21 |
| Regulatory source | reproductive toxicity | 102 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.20 |
| Regulatory source | reproductive toxicity | 129 | mg/kg bw | rat | - | developmental | reproductive toxicity | p.20 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9DBA0SBB0L | UNII | - | - | - | chemical | - |