Is Acid Red 33 safe in cosmetics?
Acid Red 33 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Acid Red 33
Also known as: 2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium salt, D & C Red No. 33, C.I. Red 33, disodium salt, C.I. Reducing Agent 6, Disodium 2-phenylazo-3,5-naphthalenedisulfonate (+7 more)
INCI: CI 17200
Acid Red 33 (CAS 3567-66-6) is a cosmetic cosmetic ingredient functioning as Cosmetic colorant. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3567-66-6 →
Auto-generated CPSR Part A draft with source citations
Function
Cosmetic colorant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
disodium;5-amino-4-hydroxy-3-phenyldiazenylnaphthalene-2,7-disulfonate
InChIKey
LQJVOKWHGUAUHK-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted – D&C Red No. 33, permanently listed (21 CFR 74.2333). Externally applied cosmetics; lip products ≤3%; mouthwashes/dentifrices. Not for eye area. Certification required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acid Red 33.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Red 33. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | = mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | = mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | = mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | = mg/kg bw | oral | rat | developmental toxicity | SCCS_vision_codex |
| NOAEL | =0.18 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.18 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.18 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.18 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =25 mg/kg bw/d | oral | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =25 mg/kg | oral | rat | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Acid Red 33 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex IV — Permitted Colorants
Product type: Red
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0.005.
BRIN Brazil/India Cosmetics
India: Restricted · max 0.005
India: Permitted Colorant
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_colorant | - | Not eye area |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 15.2% | - | - | 2007-12-18 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "D&C Red No. 33", "Chemical_Name": "Acid Red 33", "CAS_Number": "3567-66-6", "Colorant_Type": "Synthetic Dye", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved 21 CFR 74.333", "Notes": "Monoazo dye"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Regulatory List Membership (4)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Acid Red 33.
Regulatory Flags
colorant
eu_children_restricted
epa_safer_alternative
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Acid Red 33 by CAS number or substance name.
Studies
36
Lowest NOAEL
0
Highest NOAEL
2500
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg bw
ToxValDB_ECHA_IUCLID
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 15.2% | SCCS opinion extraction | - |
Known Synonyms
2,7-Naphthalenedisulfonic acid, 5-amino-4-hydroxy-3-(phenylazo)-, disodium salt
D & C Red No. 33
C.I. Red 33, disodium salt
C.I. Reducing Agent 6
Disodium 2-phenylazo-3,5-naphthalenedisulfonate
Edicol Supra 10B
Edicol Supra 10BS
EINECS 222-656-9
NSC 12190
NSC 5004
Redusol Z
UNII-9DBA0SBB0L
Chemical Function
Dye
Fragrance
Regulatory Lists
IFRA Transparency
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - general moisturizing - hand/body lotion
children; Europe; Personal care - body hygiene - body wash
children; Europe; Personal care - hair styling and care - shampoo
children; Europe; Personal care - specialized bath products - bubble bath
children; Europe; Personal care
children; Europe; Personal care
children; Europe; Personal care
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Personal care
SCIL (9/2019)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Acid Red 33 allowed in the EU?
Acid Red 33 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Red 33 do in cosmetics?
Acid Red 33 functions as: Cosmetic colorant. It is classified as a cosmetic ingredient in our database. CAS number: 3567-66-6.
What is the NOAEL for Acid Red 33?
The NOAEL (No Observed Adverse Effect Level) for Acid Red 33 is =0 mg/kg bw based on a developmental toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Acid Red 33 used outside cosmetics?
Acid Red 33 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acid Red 33 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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