NOAEL Studies Cosmetic Ingredient

Acid Red 51 (Erythrosine) NOAEL Studies

INCI: CI 45430

CAS: 16423-68-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 12.5 mg/kg bw/day rabbit oral 29 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 37 mg/kg bw/day mouse oral 210 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 68 mg/kg bw/day mouse oral 21 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 57 mg/kg bw/day mouse oral 97 week Chronic SCCS
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1 mg/kg bw/day Human oral: capsule 14 days study with volunteers EFSA ANS - 2011 - OutputID 462 - clinical chemistry - endocrine - Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive - doi:10.2903/j.efsa.2011.1854
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =10 g/kg Dog oral: feed 730 days chronic/long term toxicity EFSA FEEDAP - 2011 - OutputID 148 - clinical chemistry - endocrine - Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles - doi:10.2903/j.efsa.2011.2447
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =125 mg/kg bw Rat oral: feed - - EFSA FEEDAP - 2011 - OutputID 148 - other - endocrine - Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles - doi:10.2903/j.efsa.2011.2447
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=0.1 mg/kg bw/day Consumers - - ADI EFSA ANS - 2011 - OutputID 462 - Consumers - Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive - doi:10.2903/j.efsa.2011.1854
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI <=0.1 mg/kg bw/day Consumers - - ADI EFSA ANS - 2011 - OutputID 462 - Consumers - Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive - doi:10.2903/j.efsa.2011.1854
NTP_ICE_acute_oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1840 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3201; row=11647; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Red 3; preferred_name=FD&C Red 3; dtxsid=DTXSID7021233; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021233; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2889 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_3202; row=11648; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Red 3; preferred_name=FD&C Red 3; dtxsid=DTXSID7021233; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021233; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =2891 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_3203; row=11649; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Red 3; preferred_name=FD&C Red 3; dtxsid=DTXSID7021233; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021233; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 <2892 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_3204; row=11650; data_type=In Vivo; mixture=Chemical; chemical_name=FD&C Red 3; preferred_name=FD&C Red 3; dtxsid=DTXSID7021233; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021233; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=9316; RecordID=ARPathway2016_919; DatasetName=ARPathway2016; DTXSID=DTXSID7021233; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021233
ToxValDB_ECHA_IUCLID 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =167 mg/kg bw/day Pig oral chronic; 14 weeks chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caabe4b0a7c65d222f85; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/6/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15839307:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b820d1b82d962bc87474629e2a8c96b
ToxValDB_ECHA_IUCLID LOAEL =1000 mg/kg bw/day Rat oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5259; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/6/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15849174:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_265d69408b7d7bb35553a8926e969957
ToxValDB_ECHA_IUCLID NOAEL =1428 mg/kg bw/day Mouse dermal - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c819e4b0a7c65d216a4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=clinical signs|dermal irritation|gross pathology|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical signs|gross pathology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15816161:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d38d43ccf55736e0814f102257dfd083
ToxValDB_ECHA_IUCLID NOAEL =251 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3811; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15820357:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c9870ef985ed4ef755b85ece4598260
ToxValDB_ECHA_IUCLID NOAEL =641 mg/kg bw/day Rat oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3811; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15820358:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ea3d2abc667773f570fc77c6b62ecbf9
ToxValDB_ECHA_IUCLID NOAEL =1834 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3813; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820359:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d072c5e3674967b6c01304b4d1d3a3ff
ToxValDB_ECHA_IUCLID NOAEL =4579 mg/kg bw/day Mouse oral - chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3813; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820360:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37649217aae3aca1126bc0f48cbcfb83
ToxValDB_ECHA_IUCLID NOAEL =3750 mg/kg bw/day Mouse oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3815; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/8?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15820361:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_65cad07776a60fd2c3978d0e850b8088
ToxValDB_ECHA_IUCLID NOAEL =800 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca45; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/3?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: clinical signs|maternal: early or late resorptions|maternal: food consumption and compound intake|maternal: gross pathology|maternal: mortality|maternal: pre and post implantation loss|maternal: total litter losses by resorption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|gross pathology|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15824442:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2970388e06d04b2c57f415c221a61ea6
ToxValDB_ECHA_IUCLID NOAEL =472 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca47; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/3?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: fetal/pup body weight changes|fetus: changes in postnatal survival|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824444:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7dfad77746ba87a9af07ab3dd3e016d3
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca4d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/3?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID:15824446:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_44e548d95b8c5b1b3e30aec8968d20eb
ToxValDB_ECHA_IUCLID NOAEL =125 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5253; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/6/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15849172:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f055b54d953c03c4bb0832fddae7428a
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Dog oral chronic; 2 years chronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5260; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/6/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=body weight and weight gain|gross pathology|haematology|histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15849175:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a25e76ff712785f45a5db4900893b02b
ToxValDB_ECHA_IUCLID NOAEL =255 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b712f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: histopathology: non-neoplastic|P0: histopathology: neoplastic|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15861127:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4f1498dd3f62a8f038f68c55021284c6
ToxValDB_ECHA_IUCLID NOAEL =25 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7131; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15862079:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_82fbaa2a8ee182d33b1db2437cf584ba
ToxValDB_ECHA_IUCLID NOAEL =149 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b712f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=F1: viability|F1: clinical signs|F1: mortality|F1: body weight and weight gain|F1: food consumption and compound intake|F1: organ weights and organ / body weight ratios|F1: gross pathology|F1: histopathology: non-neoplastic|F1: histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical signs|food and/or water consumption|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15862675:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dd6e31304da9d427342ce5f11b9216ae
ToxValDB_ECHA_IUCLID NOAEL =75 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7131; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17363/7/9/2?documentUUID=e1e32936-f8dc-48fa-ae32-33e7761c3178; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival|reproduction; STUDY_GROUP=ECHA IUCLID:15862682:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b086b170bc4e00479c3ef6a968a8d3aa
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =100 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610592_15610633:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=668967ac7f7db0697a4a2a2808d5dbcb
ToxValDB_ECOTOX NOEL =10 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610592_15610633:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d8caf1cba8ba925d8be45683ac08f8ac
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =125 mg/kg bw/day Rat oral - repeat dose other LONG_REF=EFSA FEEDAP (2011). Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles. doi:10.2903/j.efsa.2011.2447.; TITLE=Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2011.2447; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=other; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=EFSA:15614064:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d59f295a4f0285708fadc685d261773
ToxValDB_EFSA NOAEL =1 mg/kg bw/day Human oral short-term; 14 days clinical LONG_REF=EFSA ANS (2011). Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive. doi:10.2903/j.efsa.2011.1854.; TITLE=Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2011.1854; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15614065:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49300fba07a38aac6da8f7476b9ebf5c
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=0.1 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afc40e4b0d99f5a87c026; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/632; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=WHO JECFA ADI:15715377:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7cf9585fda25d1260b8069b9c75dee57
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8TL7LH93FM UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6I4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8TL7LH93FM"}
openFDA substances FDA UNII substance identifier 8TL7LH93FM UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6I4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8TL7LH93FM"}
openFDA substances FDA UNII substance identifier 8TL7LH93FM UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6I4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8TL7LH93FM"}
openFDA substances FDA UNII substance identifier 8TL7LH93FM UNII - - - chemical {"approval_status":null,"molecular_formula":"C20H6I4O5.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8TL7LH93FM"}