Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Acid Red 51 (Erythrosine). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 800 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | swine | Subchronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | gerbil | Carcinogenicity | COSMOS_DB |
| NOAEL | 750 mg/kg bw/day | oral | gerbil | Chronic | COSMOS_DB |
Expert Verdict
Acid Red 51 is prohibited in EU cosmetics and de-listed for US cosmetics due to iodine content and thyroid disruption concerns; FDA revoked its food authorization in 2025.
Regulatory Flags
Frequently Asked Questions
Is Acid Red 51 (Erythrosine) safe in cosmetics?
Acid Red 51 is prohibited in EU cosmetics and de-listed for US cosmetics due to iodine content and thyroid disruption concerns; FDA revoked its food authorization in 2025. The EU classifies Acid Red 51 (Erythrosine) as "prohibited". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Acid Red 51 (Erythrosine) allowed in the EU?
Acid Red 51 (Erythrosine) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Acid Red 51 (Erythrosine) do in cosmetics?
Acid Red 51 (Erythrosine) functions as: Cosmetic colorant. It is classified as a cosmetic ingredient in our database. CAS number: 16423-68-0.
What is the Margin of Safety for Acid Red 51 (Erythrosine)?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Acid Red 51 (Erythrosine)?
The NOAEL (No Observed Adverse Effect Level) for Acid Red 51 (Erythrosine) is 800 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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