NOAEL Studies Cosmetic Ingredient

Acid Red 52 NOAEL Studies

INCI: CI 45100

CAS: 3520-42-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 100 mg/kg bw/day rat oral 90 day Subchronic SCCP; H.J. Hamann, D. Richard, K. Weber, C.Knuppe, Acid Red 52 (CI 45100): 13-week oral toxicity (gavage) study in rat, RCC Project No. 736334, Itingen /CH
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =1000 mg/kg bw/day rabbit oral 13 weeks repeated dose toxicity p.7
SCCNFP Opinion NOAEL =1000 mg/kg human - - NOAEL study p.15
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.013 mg/kg bw rat oral 13-week dermal absorption p.20
SCCS Opinion NOAEL =1000 mg/kg bw/day - oral 13 weeks genotoxicity p.16
SCCS Opinion NOAEL =1000 mg/kg bw rat oral 13-week dermal absorption p.20
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =1000 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead10e4b0a7c65d1c2568; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/12094?documentUUID=b300c255-029d-42ea-8cad-836bc333cae7; YEAR=1975; ORIGINAL_YEAR=1975; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|organ weights and organ / body weight ratios|urinalysis|body weight and weight gain|clinical biochemistry|clinical signs|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|mortality|ophthalmological examination; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|neurobehavior|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15836696:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36816715f00a44eb3b5268beedbb6dac
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX NOEL =2000 mg/kg bw/day Mouse oral acute; 1 days acute LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15598651:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e67c3961a62320bf75f3c5765493d2b
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - =1000 mg/kg human - - - p.15
Regulatory source - 1000 mg/kg - - - - p.15
Regulatory source dermal absorption 1000 mg/kg bw/day pig - - dermal absorption p.11
Regulatory source dermal absorption 1000 mg/kg bw/day pig - 3 months dermal absorption p.11
Regulatory source irritation 1000 mg/kg bw/day - oral 13 weeks irritation p.16
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rabbit oral 13 weeks repeated dose toxicity p.7
Regulatory source - 1000 mg/kg bw/day human - - - p.20
Regulatory source dermal absorption =0.013 mg/kg bw rat oral 13-week dermal absorption p.20
Regulatory source dermal absorption =1000 mg/kg bw rat oral 13-week dermal absorption p.20
Regulatory source genotoxicity 1000 mg/kg bw/day - oral 13 weeks genotoxicity p.16
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 821LWZ3R6R UNII - - - chemical -