Moderate Cosmetic Ingredient NOAEL Data

Acid Red 52

INCI: CI 45100

CAS Number
3520-42-1
Function
Cosmetic colorant (xanthene/rhodamine dye, Sulforhodamine B)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes Not listed as an approved D&C or FD&C color additive; not approved for US cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Acid Red 52. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 100 mg/kg bw/day oral rat Subchronic COSMOS_DB

Expert Verdict

Restricted to rinse-off only in EU; fluorescent tracer dye; not FDA-approved and prohibited for US cosmetics

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Concern Level: Moderate

Regulatory Flags

colorant eu_children_restricted epa_safer_alternative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Acid Red 52 safe in cosmetics?

Restricted to rinse-off only in EU; fluorescent tracer dye; not FDA-approved and prohibited for US cosmetics The EU classifies Acid Red 52 as "restricted". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.

Is Acid Red 52 allowed in the EU?

Acid Red 52 EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Red 52 do in cosmetics?

Acid Red 52 functions as: Cosmetic colorant (xanthene/rhodamine dye, Sulforhodamine B). It is classified as a cosmetic ingredient in our database. CAS number: 3520-42-1.

What is the Margin of Safety for Acid Red 52?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Red 52?

The NOAEL (No Observed Adverse Effect Level) for Acid Red 52 is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

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