NOAEL Studies Cosmetic Ingredient

Acid Violet 43 NOAEL Studies

INCI: CI 60730

CAS: 4430-18-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =200 - rat oral gavage 13 weeks NOAEL study 2, p.4
COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 27 mg/kg bw/day rat oral 91 day Subchronic SCCP; F. Goldfain-Blanc. 13-Week Toxicity Study by oral Route (Gavage) in Rats. CIT StudyNo. 10796 TCR, 1994
SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1 % rat oral subchronic repeated dose toxicity p.23
SCCS Opinion NOAEL >80 % rabbit dermal - NOAEL study p.13
SCCS Opinion NOAEL =95 % rat oral 13 weeks NOAEL study p.12
SCCS Opinion NOAEL =950 - - - - NOAEL study p.21
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =200 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf15e4b0a7c65d1cc6d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17364/7/6/2?documentUUID=953196e5-a1b2-436d-adf1-42193f710c0c; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15847319:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9fe9574799fb5d0e5ce5937c4b19114b
ECHA NOAEL =435 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba29d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17364/7/9/2?documentUUID=953196e5-a1b2-436d-adf1-42193f710c0c; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15860876:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ef4ab3c798432ae1e3121931263b17a
ECHA NOAEL =940 mg/kg bw/day Rat oral - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba287; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17364/7/9/2?documentUUID=953196e5-a1b2-436d-adf1-42193f710c0c; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15862186:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0ce20db1f24f839a7ff753ed8e714af0
Regulatory source 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 200 - rat oral gavage 13 weeks - p.4
Regulatory source - >80 % rabbit dermal - - p.13
Regulatory source - 95 % rat oral 13 weeks - p.12
Regulatory source - 95 % rat oral - - p.21
Regulatory source - 950 - - - - - p.21
Regulatory source repeated dose toxicity 1 % rat oral subchronic repeated dose toxicity p.23
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier G5UX3K0728 UNII - - - chemical -