Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

Acid Violet 43

INCI: CI 60730

CAS Number
4430-18-6
Function
Non-oxidative hair dye / colorant (anthraquinone dye)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status prohibited
EU Max Conc. 0.5%
🇺🇸 US Status permitted
US Notes Ext. D&C Violet No. 2 — listed for externally applied drugs and cosmetics; certification required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Acid Violet 43. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
LOAEL 27 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 0.119 other dermal code:3484 dermal REACH
NOAEL 300 mg/kg bw/day oral rat oral REACH
NOEL 0.1 other dermal code:3483 dermal REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH
LOAEL 1000 mg/kg bw/day dermal code:3484 dermal REACH
NOAEL 200 mg/kg bw/day oral rat oral REACH
NOAEL 400 mg/kg bw/day dermal code:3483 dermal REACH
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 1.5 mg/kg bw/day dermal code:3543 dermal REACH

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 1000 mg/kg bw/d (not specified)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 800 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 200 mg/kg bw/d (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

cir
Verdict: safe
NOAEL: 54.4 % (oral)

the Panel published a safety assessment with the conclusion that Acid Violet 43 is safe for use in hair dye formulations when free of impurities, except for the following: 18% volatile matter (at 135 C) and chlorides and sulfates (calculated as sodium salts); 0.4% water-insoluble mat

Expert Verdict

Coal tar hair dye requiring US patch-test caution labeling; not for mucous membranes. Commercial purity varies (54-60%) compared to Ext. D&C Violet No. 2 standard (84-94%).

⚠️
Concern Level: Moderate

Regulatory Flags

colorant epa_safer_alternative ifra_fragrance eu_cosing_listed

Frequently Asked Questions

Is Acid Violet 43 safe in cosmetics?

Coal tar hair dye requiring US patch-test caution labeling; not for mucous membranes. Commercial purity varies (54-60%) compared to Ext. D&C Violet No. 2 standard (84-94%). The EU classifies Acid Violet 43 as "prohibited". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Acid Violet 43 allowed in the EU?

Acid Violet 43 EU regulatory status: prohibited. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Acid Violet 43 do in cosmetics?

Acid Violet 43 functions as: Non-oxidative hair dye / colorant (anthraquinone dye). It is classified as a cosmetic ingredient in our database. CAS number: 4430-18-6.

What is the Margin of Safety for Acid Violet 43?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Acid Violet 43?

The NOAEL (No Observed Adverse Effect Level) for Acid Violet 43 is 27 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check Acid Violet 43 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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