ACRYLAMIDE NOAEL Studies

ATSDR_toxval_ATSDR_MRLs.xlsx 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ATSDR_toxval_ATSDR_MRLs.xlsx	NOAEL	=0.038	mg/kg/day	Rat (F344; M/F)	oral	subchronic; 90 days	subchronic	ATSDR MRLs; row_hash=544ae51a7589650d; source_hash=ToxValhc_52d9e09345c4adc3fcd988d19e8648d2; raw_endpoint_type=NOAEL (HED); raw_endpoint_subtype=; raw_value=0.038; raw_unit=mg/kg/day; method=drinking water; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Burek JD, Albee RR, Beyer JE, et al. 1980. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4(5- 6):157-182.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03
ATSDR_toxval_ATSDR_MRLs.xlsx	NOAEL	=0.2	mg/kg/day	Rat (F344; M/F)	oral	subchronic; 90 days	subchronic	ATSDR MRLs; row_hash=f3d1ec043c3c502f; source_hash=ToxValhc_e4e244a6105b39dabf73f9f1d83d777f; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.2; raw_unit=mg/kg/day; method=drinking water; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Burek JD, Albee RR, Beyer JE, et al. 1980. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4(5- 6):157-182.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03

California Proposition 65 12 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
California Proposition 65	California Proposition 65 MADL	AB140	ug/day	-	-	2011-02-25	Maximum allowable dose level	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 MADL	AB140	ug/day	-	-	2011-02-25	Maximum allowable dose level	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 MADL	AB140	ug/day	-	-	2011-02-25	Maximum allowable dose level	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"row_type":"madl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 NSRL	AB0.2	ug/day	-	-	1990-01-01	No significant risk level	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 NSRL	AB0.2	ug/day	-	-	1990-01-01	No significant risk level	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 NSRL	AB0.2	ug/day	-	-	1990-01-01	No significant risk level	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","row_type":"nsrl","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABcancer	listing type	-	-	1990-01-01	California Proposition 65 listing	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental, male	listing type	-	-	2011-02-25	California Proposition 65 listing	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABcancer	listing type	-	-	1990-01-01	California Proposition 65 listing	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental, male	listing type	-	-	2011-02-25	California Proposition 65 listing	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABcancer	listing type	-	-	1990-01-01	California Proposition 65 listing	{"cancer_reproductive":"cancer","listed_date":"1990-01-01","listing_mechanism":"AB","madl":null,"nsrl":"0.2","source_table":"prop65_listings"}
California Proposition 65	California Proposition 65 listing	ABdevelopmental, male	listing type	-	-	2011-02-25	California Proposition 65 listing	{"cancer_reproductive":"developmental, male","listed_date":"2011-02-25","listing_mechanism":"AB","madl":"140","nsrl":null,"source_table":"prop65_listings"}

EPA_IRIS_iris_rfc_systems.csv 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EPA_IRIS_iris_rfc_systems.csv	HEC 5 (BMDL)	=0.18	mg/m^3	-	inhalation	chronic	IRIS chronic inhalation RfC system PoD	row_hash=63e1d02e40a8b94a; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=HEC 5 (BMDL): 0.18 mg/m^3; system=Nervous; basis=Degenerative nerve changes; point_of_departure=HEC 5 (BMDL): 0.18 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID5020027; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; rfc_last_updated=03/22/2010; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0286_summary.pdf
EPA_IRIS_iris_rfc_systems.csv	RfC	=0.006	mg/m^3	-	inhalation	chronic	IRIS chronic inhalation RfC system	row_hash=d6419107e07f1029; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=6e-3; system=Nervous; basis=Degenerative nerve changes; point_of_departure=HEC 5 (BMDL): 0.18 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID5020027; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; rfc_last_updated=03/22/2010; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0286_summary.pdf

EPA_IRIS_iris_rfd_systems.csv 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
EPA_IRIS_iris_rfd_systems.csv	HED (BMDL)	=0.053	mg/kg/day	-	oral	chronic	IRIS chronic oral RfD system PoD	row_hash=8e2e69bbd3f5dd1d; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=HED (BMDL): 0.053 mg/kg-day; system=Nervous; basis=Degenerative nerve changes; point_of_departure=HED (BMDL): 0.053 mg/kg-day; composite_uf=30; confidence=Medium/High; dtxsid=DTXSID5020027; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; rfd_last_updated=03/22/2010; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0286_summary.pdf
EPA_IRIS_iris_rfd_systems.csv	RfD	=0.002	mg/kg/day	-	oral	chronic	IRIS chronic oral RfD system	row_hash=f45c027f676579e9; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-3; system=Nervous; basis=Degenerative nerve changes; point_of_departure=HED (BMDL): 0.053 mg/kg-day; composite_uf=30; confidence=Medium/High; dtxsid=DTXSID5020027; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; rfd_last_updated=03/22/2010; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0286_summary.pdf

IARC Monographs 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
IARC Monographs	IARC carcinogenicity classification	2A	IARC group	-	-	1994	IARC Monographs	{"additional_info":"NB Overall evaluation upgraded to Group 2A with supporting evidence from other relevant data; volume_publication_year=1994","evaluation_year":1994,"source_table":"iarc_classifications","volume":"60, Sup 7"}

INCHEM_WHO_jecfa_jeceval_jec_41 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
INCHEM_WHO_jecfa_jeceval_jec_41	NOEL	=0.2	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jeceval_jec_41; title=JECFA Evaluations-ACRYLAMIDE-; path=mirror/documents/jecfa/jeceval/jec_41.htm; row_hash=7f1c63f76a4647aa; raw_unit=mg/kg bw per day; context=For morphological changes in nerves the no-observed-effect level was 0.2 mg/kg bw per day; the margin of exposure at mean intake was 200 and at high intake was 50.
INCHEM_WHO_jecfa_jeceval_jec_41	NOEL	=2	mg/kg bw/day	-	-	-	Developmental toxicity	document_id=jecfa_jeceval_jec_41; title=JECFA Evaluations-ACRYLAMIDE-; path=mirror/documents/jecfa/jeceval/jec_41.htm; row_hash=d61f2812f39ce965; raw_unit=mg/kg bw per day; context=For reproductive, developmental, and other non-neoplastic effects the no-observed-effect level was 2 mg/kg bw per day; the margin of exposure at mean intake was 2000 and at high intake was 500.

INCHEM_WHO_jecfa_jecmono_v63je01 70 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=25.7	mg/kg bw/day	Rat	oral	2-year	Chronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7e3c2708469119fd; raw_unit=mg/kg bw per day; context=The lowest no-observed-adverse-effect level (NOAEL) following dietary administration was 3.0 mg/kg bw per day in a 2-year dietary study in rats in which the LOAEL for diarrhoea was 25.7 mg/kg bw per day (Arnold et al., 2003).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.25	mg/kg bw/day	Mouse	-	-	Reproductive toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=62b2febd7aacf825; raw_unit=mg/kg bw per day; context=l exposure to mercury(II) chloride at 0.25-1.00 mg/kg bw per day produced adverse effects on the reproductive performance of mice, in the absence of overt mercury toxicity, with a LOAEL of 0.25 mg/kg bw per day, as mercury(II) chloride, or 0.185 mg/kg bw per day, as mercury (Khan et al., 2004).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.3	mg/kg bw/day	Mouse	-	14-day	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=a9271803f33ac122; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Another short-term (14-day) study (Kim, Johnson & Sharma, 2003) showed that for the immune system in mice, the LOAEL was 300 ug/kg bw per day, as mercury, but the NOEL was 60 ug/kg bw per day, as mercury (respectively higher and lower than the 200 ug/kg bw per day NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.0015	mg/kg bw/day	Rat; Mouse	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=d85c593dfaef9c7f; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Since both the LOAEL of 1.5 ug/kg bw per day, as mercury, in rats and the NOEL of 60 ug/kg bw per day, as mercury, in mice are lower than the current lowest NOAEL of 200 ug/kg bw per day, as mercury, they may be considered relevant for updating the hazard characterizations of inorganic mercury.
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=25.7	mg/kg bw/day	Rat	oral	2-year	Chronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7e3c2708469119fd; raw_unit=mg/kg bw per day; context=The lowest no-observed-adverse-effect level (NOAEL) following dietary administration was 3.0 mg/kg bw per day in a 2-year dietary study in rats in which the LOAEL for diarrhoea was 25.7 mg/kg bw per day (Arnold et al., 2003).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.25	mg/kg bw/day	Mouse	-	-	Reproductive toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=62b2febd7aacf825; raw_unit=mg/kg bw per day; context=l exposure to mercury(II) chloride at 0.25-1.00 mg/kg bw per day produced adverse effects on the reproductive performance of mice, in the absence of overt mercury toxicity, with a LOAEL of 0.25 mg/kg bw per day, as mercury(II) chloride, or 0.185 mg/kg bw per day, as mercury (Khan et al., 2004).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.3	mg/kg bw/day	Mouse	-	14-day	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=a9271803f33ac122; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Another short-term (14-day) study (Kim, Johnson & Sharma, 2003) showed that for the immune system in mice, the LOAEL was 300 ug/kg bw per day, as mercury, but the NOEL was 60 ug/kg bw per day, as mercury (respectively higher and lower than the 200 ug/kg bw per day NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	LOAEL	=0.0015	mg/kg bw/day	Rat; Mouse	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=d85c593dfaef9c7f; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Since both the LOAEL of 1.5 ug/kg bw per day, as mercury, in rats and the NOEL of 60 ug/kg bw per day, as mercury, in mice are lower than the current lowest NOAEL of 200 ug/kg bw per day, as mercury, they may be considered relevant for updating the hazard characterizations of inorganic mercury.
INCHEM_WHO_jecfa_jecmono_v63je01	LOEL	=0.01	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=50877ddb7c77e3cb; raw_unit=mg/kg bw per day; context=The dose of 0.01 mg/kg bw per day may be a lowest-observed-effect level (LOEL) for thyroid hormone changes.
INCHEM_WHO_jecfa_jecmono_v63je01	LOEL	=0.01	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=50877ddb7c77e3cb; raw_unit=mg/kg bw per day; context=The dose of 0.01 mg/kg bw per day may be a lowest-observed-effect level (LOEL) for thyroid hormone changes.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.5	mg/kg bw/day	-	-	90-day	Subchronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7ea5174995258129; raw_unit=mg/kg bw per day; context=In both long-term studies, the NOAEL for nerve damage, detected by light microscopy, was 0.5 mg/kg bw per day, whereas in the 90-day study, the NOAEL for morphological changes in nerves, detected by electron microscopy, was 0.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.2	mg/kg bw/day	-	-	90-day	Subchronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=ee64f167c0cc68ad; raw_unit=mg/kg bw per day; context=In both long-term studies, the NOAEL for nerve damage, detected by light microscopy, was 0.5 mg/kg bw per day, whereas in the 90-day study, the NOAEL for morphological changes in nerves, detected by electron microscopy, was 0.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.67	mg/kg bw/day	Rat	-	-	Reproductive toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7d99f88872e7947b; raw_unit=mg/kg bw per day; context=For acrylamide-treated rats, the NOAEL for peripheral nerve axonal degeneration was 0.67 mg/kg bw per day in males and 1.88 mg/kg bw per day in females.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2	mg/kg bw/day	-	-	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b89c15225bb03691; raw_unit=mg/kg bw per day; context=The overall NOAEL for reproductive and developmental toxicity was 2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=10	mg/L	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=6f17f9ba7a8c53e3; raw_unit=mg/l; context=The NOAEL was 10 mg/l in drinking- water, equivalent to 0.73 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.73	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=a428a2efd77b2a24; raw_unit=mg/kg bw per day; context=The NOAEL was equivalent to 0.73 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.11	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=130334763f97d804; raw_unit=mg/kg bw per day; context=As only one dose was tested in vivo, a NOAEL could not be established, but would be below 0.11 mg/kg bw per day (Pinton et al., 2009).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=1	mg/kg bw/day	Mouse	-	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=955f036836ac9ec2; raw_unit=mg/kg bw per day; context=A NOAEL of 1 mg/kg bw per day was derived based on reduced epididymal (right and left) and seminal vesicle weights in the next higher dose group (Sprando et al., 2005). (b) Developmental toxicity (i) Mice In a review aimed at determining the relative developmental toxicity potential of DO
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.375	mg/kg bw/day	Mouse	oral	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=c25fc35813c010e4; raw_unit=mg/kg bw per day; context=oxicity (i) Mice In a review aimed at determining the relative developmental toxicity potential of DON and benomyl, both present on wheat, Hicks et al. (2000) identified a dietary NOAEL for DON for decreased body weight in mouse pups of 0.375 mg/kg bw per day from Khera et al. (1984).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2.5	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=172e519b5a573c7a; raw_unit=mg/kg bw per day; context=The NOAEL for teratogenicity is 2.5 mg/kg bw per day based on the increase in misaligned and fused sternebrae at 5 mg/kg bw per day (Collins et al., 2006). (iii) In vitro In porcine cumulus oocyte complexes, DON (0.94, 1.88, 3.75 or 7.5 umol/l [0.28, 0.557, 1.11 or 2.2 ug/ml]) dose-dependently decreased maturat
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=9d5ee4bbc09452c0; raw_unit=mg/kg bw; context=As effects on viral clearance were seen in the lowest dose group, a NOAEL could not be derived, but would be lower than 2 mg/kg bw (Li et al., 2007).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.3	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=46069506c7b3bfe3; raw_unit=mg/kg bw per day; context=As only one dose was given, a NOAEL could not be derived, but would be lower than 0.3 mg/kg bw per day (Landgren, Hendrich & Kohut, 2006).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=3.75	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=0f0ebd0b6708d0db; raw_unit=mg/kg bw per day; context=As only one dose was tested, a NOAEL for the reversible increase in serum IgA levels could not be determined, but would be below 3.75 mg/kg bw per day (Pestka & Dong, 1994).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.088	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=699a3cb88b005b99; raw_unit=mg/kg bw per day; context=As only one dose was given, a NOAEL could not be derived, but would be lower than 2.2 mg/kg feed, equivalent to 0.088 mg/kg bw per day (Pinton et al., 2008).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.1	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b56c9bf6f98ec8eb; raw_unit=mg/kg bw; context=As the (reversible) effect on SOCS mRNA expression in liver was seen in the lowest dose group, a NOAEL could not be derived, but would be lower than 0.1 mg/kg bw (Amuzie, Shinozuka & Pestka, 2009).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=5	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=ef703523daac0f42; raw_unit=mg/kg bw.; context=As effects were seen in all dose groups, a NOAEL for 3-Ac-DON could not be derived, but would be lower than 5 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.75	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=4b4019aadde09595; raw_unit=mg/ kg bw per day; context=A NOAEL of 5 mg/kg diet could be derived, equivalent to 0.75 mg/ kg bw per day (Tomar, Blakley & Decoteau, 1987).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.00428571428571429	mg/kg bw/day	-	-	5 days	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=d1d1b5168dbb5294; raw_unit=mg/kg bw per day; unit_normalization=converted from weekly dose; context=Thus, the lowest dose tested (0.03 mg/kg bw per day, 5 days/week) appears to be a no-observed- adverse-effect level (NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.23	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=65c77c9e31b26dfe; raw_unit=mg/kg bw per day; context=A NOAEL from this study was identified as 0.23 mg/kg bw per day, as mercury(II) chloride (0.20 mg/kg bw per day, as mercury) (NTP, 1993).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.00023	mg/kg bw/day	Rat	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=05ad4076fc67729e; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Relative kidney weight increases were observed in both sexes of rats, with a NOAEL estimated at 0.23 ug/kg bw per day, as mercury (lowest dose tested).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=1.9	mg/kg bw/day	Mouse	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b8bc393056ca175c; raw_unit=mg/kg bw per day; context=While kidney effects were also observed in mice (more prevalent in males), they generally occurred at higher doses (NOAEL of 1.9 mg/kg bw per day, as mercury).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.006	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=1375541006163d69; raw_unit=mg/kg bw per day; context=They identified a freestanding NOAEL of 0.006 mg/kg bw per day for T4 decrease in children from the epidemiological study of Crump et al. (2000), supported by the threshold for inhibition of iodine uptake of 0.006 mg/kg bw per day from the study of Greer et al. (2002) as a measurable surrogate for the critical effect of
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.003	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=242ed2e1368cd174; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=NOAEL, no-observed-adverse-effect level Arsenic The inorganic arsenic lower limit on the benchmark dose for a 0.5% increased incidence of lung cancer (BMDL0.5) was determined from epidemiological studies to be 3.0 ug/kg bw per day (2-7 ug/kg bw per day based on the range of estimated total dietary exposure) using a range of assumptions to estimate total dietary exposure to inorganic arsenic from drinking-water and food.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.5	mg/kg bw/day	-	-	90-day	Subchronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7ea5174995258129; raw_unit=mg/kg bw per day; context=In both long-term studies, the NOAEL for nerve damage, detected by light microscopy, was 0.5 mg/kg bw per day, whereas in the 90-day study, the NOAEL for morphological changes in nerves, detected by electron microscopy, was 0.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.2	mg/kg bw/day	-	-	90-day	Subchronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=ee64f167c0cc68ad; raw_unit=mg/kg bw per day; context=In both long-term studies, the NOAEL for nerve damage, detected by light microscopy, was 0.5 mg/kg bw per day, whereas in the 90-day study, the NOAEL for morphological changes in nerves, detected by electron microscopy, was 0.2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.67	mg/kg bw/day	Rat	-	-	Reproductive toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=7d99f88872e7947b; raw_unit=mg/kg bw per day; context=For acrylamide-treated rats, the NOAEL for peripheral nerve axonal degeneration was 0.67 mg/kg bw per day in males and 1.88 mg/kg bw per day in females.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2	mg/kg bw/day	-	-	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b89c15225bb03691; raw_unit=mg/kg bw per day; context=The overall NOAEL for reproductive and developmental toxicity was 2 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=10	mg/L	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=6f17f9ba7a8c53e3; raw_unit=mg/l; context=The NOAEL was 10 mg/l in drinking- water, equivalent to 0.73 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.73	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=a428a2efd77b2a24; raw_unit=mg/kg bw per day; context=The NOAEL was equivalent to 0.73 mg/kg bw per day.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.11	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=130334763f97d804; raw_unit=mg/kg bw per day; context=As only one dose was tested in vivo, a NOAEL could not be established, but would be below 0.11 mg/kg bw per day (Pinton et al., 2009).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=1	mg/kg bw/day	Mouse	-	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=955f036836ac9ec2; raw_unit=mg/kg bw per day; context=A NOAEL of 1 mg/kg bw per day was derived based on reduced epididymal (right and left) and seminal vesicle weights in the next higher dose group (Sprando et al., 2005). (b) Developmental toxicity (i) Mice In a review aimed at determining the relative developmental toxicity potential of DO
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.375	mg/kg bw/day	Mouse	oral	-	Developmental toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=c25fc35813c010e4; raw_unit=mg/kg bw per day; context=oxicity (i) Mice In a review aimed at determining the relative developmental toxicity potential of DON and benomyl, both present on wheat, Hicks et al. (2000) identified a dietary NOAEL for DON for decreased body weight in mouse pups of 0.375 mg/kg bw per day from Khera et al. (1984).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2.5	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=172e519b5a573c7a; raw_unit=mg/kg bw per day; context=The NOAEL for teratogenicity is 2.5 mg/kg bw per day based on the increase in misaligned and fused sternebrae at 5 mg/kg bw per day (Collins et al., 2006). (iii) In vitro In porcine cumulus oocyte complexes, DON (0.94, 1.88, 3.75 or 7.5 umol/l [0.28, 0.557, 1.11 or 2.2 ug/ml]) dose-dependently decreased maturat
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=2	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=9d5ee4bbc09452c0; raw_unit=mg/kg bw; context=As effects on viral clearance were seen in the lowest dose group, a NOAEL could not be derived, but would be lower than 2 mg/kg bw (Li et al., 2007).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.3	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=46069506c7b3bfe3; raw_unit=mg/kg bw per day; context=As only one dose was given, a NOAEL could not be derived, but would be lower than 0.3 mg/kg bw per day (Landgren, Hendrich & Kohut, 2006).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=3.75	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=0f0ebd0b6708d0db; raw_unit=mg/kg bw per day; context=As only one dose was tested, a NOAEL for the reversible increase in serum IgA levels could not be determined, but would be below 3.75 mg/kg bw per day (Pestka & Dong, 1994).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.088	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=699a3cb88b005b99; raw_unit=mg/kg bw per day; context=As only one dose was given, a NOAEL could not be derived, but would be lower than 2.2 mg/kg feed, equivalent to 0.088 mg/kg bw per day (Pinton et al., 2008).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.1	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b56c9bf6f98ec8eb; raw_unit=mg/kg bw; context=As the (reversible) effect on SOCS mRNA expression in liver was seen in the lowest dose group, a NOAEL could not be derived, but would be lower than 0.1 mg/kg bw (Amuzie, Shinozuka & Pestka, 2009).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=5	mg/kg bw	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=ef703523daac0f42; raw_unit=mg/kg bw.; context=As effects were seen in all dose groups, a NOAEL for 3-Ac-DON could not be derived, but would be lower than 5 mg/kg bw.
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.75	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=4b4019aadde09595; raw_unit=mg/ kg bw per day; context=A NOAEL of 5 mg/kg diet could be derived, equivalent to 0.75 mg/ kg bw per day (Tomar, Blakley & Decoteau, 1987).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.00428571428571429	mg/kg bw/day	-	-	5 days	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=d1d1b5168dbb5294; raw_unit=mg/kg bw per day; unit_normalization=converted from weekly dose; context=Thus, the lowest dose tested (0.03 mg/kg bw per day, 5 days/week) appears to be a no-observed- adverse-effect level (NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.23	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=65c77c9e31b26dfe; raw_unit=mg/kg bw per day; context=A NOAEL from this study was identified as 0.23 mg/kg bw per day, as mercury(II) chloride (0.20 mg/kg bw per day, as mercury) (NTP, 1993).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.00023	mg/kg bw/day	Rat	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=05ad4076fc67729e; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Relative kidney weight increases were observed in both sexes of rats, with a NOAEL estimated at 0.23 ug/kg bw per day, as mercury (lowest dose tested).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=1.9	mg/kg bw/day	Mouse	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=b8bc393056ca175c; raw_unit=mg/kg bw per day; context=While kidney effects were also observed in mice (more prevalent in males), they generally occurred at higher doses (NOAEL of 1.9 mg/kg bw per day, as mercury).
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.006	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=1375541006163d69; raw_unit=mg/kg bw per day; context=They identified a freestanding NOAEL of 0.006 mg/kg bw per day for T4 decrease in children from the epidemiological study of Crump et al. (2000), supported by the threshold for inhibition of iodine uptake of 0.006 mg/kg bw per day from the study of Greer et al. (2002) as a measurable surrogate for the critical effect of
INCHEM_WHO_jecfa_jecmono_v63je01	NOAEL	=0.003	mg/kg bw/day	-	oral	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=242ed2e1368cd174; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=NOAEL, no-observed-adverse-effect level Arsenic The inorganic arsenic lower limit on the benchmark dose for a 0.5% increased incidence of lung cancer (BMDL0.5) was determined from epidemiological studies to be 3.0 ug/kg bw per day (2-7 ug/kg bw per day based on the range of estimated total dietary exposure) using a range of assumptions to estimate total dietary exposure to inorganic arsenic from drinking-water and food.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.1	mg/kg bw/day	Mouse	oral	2-year	Chronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=956662abc52531aa; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The Committee established a provisional maximum tolerable daily intake (PMTDI) of 1 ug/kg body weight (bw) on the basis of the no- observed-effect level (NOEL)1 of 100 ug/kg bw per day for decreased body weight gain reported in a 2-year feeding study in mice and application of a safety factor of 100.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.1	mg/kg bw	Mouse; Pig	-	-	Acute toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=8836f2653813c0b1; raw_unit=mg/kg bw; context=Most mechanistic studies on immunological end-points in mice and pigs were unsuitable for deriving a NOAEL, but in one study, an acute NOEL of 0.1 mg/kg bw was derived based on suppression of hepatic mRNA for IGFAL.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.06	mg/kg bw/day	Mouse	-	14-day	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=f3172783d6594d04; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Another short-term (14-day) study (Kim, Johnson & Sharma, 2003) showed that for the immune system in mice, the LOAEL was 300 ug/kg bw per day, as mercury, but the NOEL was 60 ug/kg bw per day, as mercury (respectively higher and lower than the 200 ug/kg bw per day NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=1.17	mg/kg bw/day	-	-	7 days	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=66abbbb4eeea3d8c; raw_unit=mg/kg bw per day; context=This study indicates a NOEL of 1.170 mg/kg bw per day for effects on thyroid hormones and a NOEL of 0.205 mg/kg bw per day for effects on thyroid histology following short-term (7 days) dosing of ammonium perchlorate.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.007	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=2a9dfed60084d026; raw_unit=mg/kg bw per day; context=The NOEL from this study for effects of perchlorate on uptake of iodine by the thyroid was 0.007 mg/kg bw per day, and the NOEL for effects on levels of thyroid hormones and TSH was the highest dose tested, 0.5 mg/kg bw per day (Greer et al., 2002).
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.1	mg/kg bw/day	Mouse	oral	2-year	Chronic toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=956662abc52531aa; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The Committee established a provisional maximum tolerable daily intake (PMTDI) of 1 ug/kg body weight (bw) on the basis of the no- observed-effect level (NOEL)1 of 100 ug/kg bw per day for decreased body weight gain reported in a 2-year feeding study in mice and application of a safety factor of 100.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.1	mg/kg bw	Mouse; Pig	-	-	Acute toxicity	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=8836f2653813c0b1; raw_unit=mg/kg bw; context=Most mechanistic studies on immunological end-points in mice and pigs were unsuitable for deriving a NOAEL, but in one study, an acute NOEL of 0.1 mg/kg bw was derived based on suppression of hepatic mRNA for IGFAL.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.06	mg/kg bw/day	Mouse	-	14-day	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=f3172783d6594d04; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=Another short-term (14-day) study (Kim, Johnson & Sharma, 2003) showed that for the immune system in mice, the LOAEL was 300 ug/kg bw per day, as mercury, but the NOEL was 60 ug/kg bw per day, as mercury (respectively higher and lower than the 200 ug/kg bw per day NOAEL).
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=1.17	mg/kg bw/day	-	-	7 days	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=66abbbb4eeea3d8c; raw_unit=mg/kg bw per day; context=This study indicates a NOEL of 1.170 mg/kg bw per day for effects on thyroid hormones and a NOEL of 0.205 mg/kg bw per day for effects on thyroid histology following short-term (7 days) dosing of ammonium perchlorate.
INCHEM_WHO_jecfa_jecmono_v63je01	NOEL	=0.007	mg/kg bw/day	-	-	-	Toxicology study	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=2a9dfed60084d026; raw_unit=mg/kg bw per day; context=The NOEL from this study for effects of perchlorate on uptake of iodine by the thyroid was 0.007 mg/kg bw per day, and the NOEL for effects on levels of thyroid hormones and TSH was the highest dose tested, 0.5 mg/kg bw per day (Greer et al., 2002).
INCHEM_WHO_jecfa_jecmono_v63je01	TDI	=0.001	mg/kg bw/day	Mouse	oral	2-year	Health guidance value	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=3d6d865000b0aceb; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The Committee established a provisional maximum tolerable daily intake (PMTDI) of 1 ug/kg body weight (bw) on the basis of the no- observed-effect level (NOEL)1 of 100 ug/kg bw per day for decreased body weight gain reported in a 2-year feeding study in mice and application of a safety factor of 100.
INCHEM_WHO_jecfa_jecmono_v63je01	TDI	=0.002	mg/kg bw/day	Rat; Mouse	oral	5 days	Health guidance value	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=54c1815033a8a150; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The last study was used to derive an intermediate MRL MERCURY (addendum) 613 for mercury of 2.0 ug/kg bw per day (ATSDR, 1999) and a TDI for mercury of 2.0 ug/kg bw per day (IPCS, 2003), based on the no-observed-adverse-effect level (NOAEL) of 0.23 mg/kg bw per day, as mercury(II) chloride, in rats following 5 days/ week administration by gavage. (a) Mice In the NTP (1993) study, B6C3F1 mice (10 animals of each sex per group) we
INCHEM_WHO_jecfa_jecmono_v63je01	TDI	=0.001	mg/kg bw/day	Mouse	oral	2-year	Health guidance value	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=3d6d865000b0aceb; raw_unit=ug/kg body weight; unit_normalization=converted from micrograms; context=The Committee established a provisional maximum tolerable daily intake (PMTDI) of 1 ug/kg body weight (bw) on the basis of the no- observed-effect level (NOEL)1 of 100 ug/kg bw per day for decreased body weight gain reported in a 2-year feeding study in mice and application of a safety factor of 100.
INCHEM_WHO_jecfa_jecmono_v63je01	TDI	=0.002	mg/kg bw/day	Rat; Mouse	oral	5 days	Health guidance value	document_id=jecfa_jecmono_v63je01; title=Safety Evaluation of Certain Contaminants in Food; path=mirror/documents/jecfa/jecmono/v63je01.pdf; row_hash=54c1815033a8a150; raw_unit=ug/kg bw per day; unit_normalization=converted from micrograms; context=The last study was used to derive an intermediate MRL MERCURY (addendum) 613 for mercury of 2.0 ug/kg bw per day (ATSDR, 1999) and a TDI for mercury of 2.0 ug/kg bw per day (IPCS, 2003), based on the no-observed-adverse-effect level (NOAEL) of 0.23 mg/kg bw per day, as mercury(II) chloride, in rats following 5 days/ week administration by gavage. (a) Mice In the NTP (1993) study, B6C3F1 mice (10 animals of each sex per group) we

NTP_ICE_acute_inhalation 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_inhalation	LC50	>0.0166	mg/L	-	Inhalation	Duration=6 hr	In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity	sheet=Data; excel_row=2750; Record_ID=acute_inhalation_3575; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0166; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027

NTP_ICE_acute_oral 10 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_acute_oral	LD50	=170	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	JRC AcutoxBase (undated); record_id=acute_oral_10409; row=8414; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	>150	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	record_id=acute_oral_10407; row=8415; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=53	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	JRC AcutoxBase (undated); record_id=acute_oral_10403; row=8416; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=175	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	JRC AcutoxBase (undated); record_id=acute_oral_10411; row=8417; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=490	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10419; row=8418; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=124	mg/kg bw	Rat	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10405; row=8419; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=565	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10421; row=8420; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=203	mg/kg bw	Rat (Female)	oral	acute	Rat Acute Oral Toxicity	JRC AcutoxBase (undated); record_id=acute_oral_10417; row=8421; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	=202	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	JRC AcutoxBase (undated); record_id=acute_oral_10415; row=8422; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx
NTP_ICE_acute_oral	LD50	<180	mg/kg bw	Rat (Male)	oral	acute	Rat Acute Oral Toxicity	record_id=acute_oral_10413; row=8423; data_type=In Vivo; mixture=Chemical; chemical_name=Acrylamide; preferred_name=Acrylamide; dtxsid=DTXSID5020027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5020027; source_file=acute_oral.xlsx

NTP_ICE_cancer 8 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_cancer	IARC group	2	unitless	-	-	-	WOE; IARC Carcinogenicity	sheet=Data; excel_row=5194; Record_ID=cancer_4111; Data_Type=WOE; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2A; Response_Unit=Unitless; URL=http://publications.iarc.fr/78; http://publications.iarc.fr/139; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	Inhalation risk unit	0.0001	ug/m3	-	Inhalation	-	WOE; IRIS Carcinogenicity	sheet=Data; excel_row=5200; Record_ID=cancer_4113; Data_Type=WOE; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=IRIS Carcinogenicity; Endpoint=Inhalation risk unit; Response=1E-4; Response_Unit=ug/m3; Route=Inhalation; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0286_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	Oral slope factor	0.5	mg/kg bw/day	-	Oral	-	WOE; IRIS Carcinogenicity	sheet=Data; excel_row=5203; Record_ID=cancer_4114; Data_Type=WOE; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=IRIS Carcinogenicity; Endpoint=Oral slope factor; Response=0.5; Response_Unit=mg/kg/day; Route=Oral; URL=https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0286_summary.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	POLY-3 lowest dose	12.5	mg/L	Mouse	Dosed drinking water	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=5162; Record_ID=cancer_4105; Data_Type=In Vivo; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=12.5; Response_Unit=mg/L; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Male; Route=Dosed drinking water; Level_of_Evidence=Clear evidence; Tissue=Lung; Lesion=Alveolar/bronchiolar adenoma or alveolar/bronchiolar carcinoma; Reference=TR-575; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	POLY-3 lowest dose	25	mg/L	Mouse	Dosed drinking water	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=5163; Record_ID=cancer_4105; Data_Type=In Vivo; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=25; Response_Unit=mg/L; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Male; Route=Dosed drinking water; Level_of_Evidence=Clear evidence; Tissue=Forestomach; Lesion=Squamous cell carcinoma or papilloma squamous; Reference=TR-575; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	POLY-3 lowest dose	6.25	mg/L	Mouse	Dosed drinking water	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=5169; Record_ID=cancer_4109; Data_Type=In Vivo; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=6.25; Response_Unit=mg/L; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Female; Route=Dosed drinking water; Level_of_Evidence=Clear evidence; Tissue=Harderian gland; Lesion=Adenoma; Reference=TR-575; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	POLY-3 lowest dose	50	mg/L	Mouse	Dosed drinking water	-	In Vivo; Two year cancer bioassay	sheet=Data; excel_row=5171; Record_ID=cancer_4109; Data_Type=In Vivo; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=50; Response_Unit=mg/L; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Female; Route=Dosed drinking water; Level_of_Evidence=Clear evidence; Tissue=Ovary; Lesion=Granulosa cell tumor(Benign); Reference=TR-575; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027
NTP_ICE_cancer	Top dose	0.7	mM	Mouse	Dosed drinking water	-	In Vivo; NTP Carcinogenicity	sheet=Data; excel_row=5168; Record_ID=cancer_4109; Data_Type=In Vivo; Formulation_Name=Acrylamide; Mixture=Chemical; DTXSID=DTXSID5020027; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=0.7; Response_Unit=mM; Species=Mouse; Strain=B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-); Sex=Female; Route=Dosed drinking water; Reference=TR-575; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr575/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027

NTP_ICE_dart 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_dart	LOEL	7.5	mg/kg bw/day	Rat	Oral	-	In Vivo; DART, In life observation	sheet=Data; excel_row=71631; Record_ID=dart_5801; Data_Type=In Vivo; DTXSID=DTXSID5020027; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 5198; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027

NTP_ICE_endocrine 1 endpoint

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
NTP_ICE_endocrine	Model Score	0	unitless	-	-	-	ARPathway2016; AR Pathway Model, Antagonist	sheet=Integrated_approaches; excel_row=4628; RecordID=ARPathway2016_1580; DatasetName=ARPathway2016; DTXSID=DTXSID5020027; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020027; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020027

ToxValDB_ATSDR_MRLs 10 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ATSDR_MRLs	BMDL (05 HED)	=0.042	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Friedman MA, Dulak LH, Stedham MA. 1995. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 27(1):95-105.; TITLE=A lifetime oncogenicity study in rats with acrylamide; AUTHOR=Friedman MA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447332:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f3dbcaf8ac3d8ac43ebb463cd7a4cd57
ToxValDB_ATSDR_MRLs	BMDL (05)	=0.0170658	mg/L	Rat	oral	chronic; 2 years	chronic	LONG_REF=Friedman MA, Dulak LH, Stedham MA. 1995. A lifetime oncogenicity study in rats with acrylamide. Fundam Appl Toxicol 27(1):95-105.; TITLE=A lifetime oncogenicity study in rats with acrylamide; AUTHOR=Friedman MA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447333:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8f13b753570228f03eb4c09933a13c34
ToxValDB_ATSDR_MRLs	BMDL (10 HED)	=0.31	mg/kg bw/day	Rat	oral	short-term; 5 days	short-term	LONG_REF=Sublet VH, Zenick H, Smith MK. 1989. Factors associated with reduced fertility and implantation rates in females mated to acrylamide-treated rats. Toxicology 55:53-67; TITLE=Factors associated with reduced fertility and implantation rates in females mated to acrylamide-treated rats; AUTHOR=Sublet VH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447328:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_94871fb00e2d72a451223158c127aba0
ToxValDB_ATSDR_MRLs	BMDL (10)	=0.126285	mg/L	Rat	oral	short-term; 5 days	short-term	LONG_REF=Sublet VH, Zenick H, Smith MK. 1989. Factors associated with reduced fertility and implantation rates in females mated to acrylamide-treated rats. Toxicology 55:53-67; TITLE=Factors associated with reduced fertility and implantation rates in females mated to acrylamide-treated rats; AUTHOR=Sublet VH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=reproductive; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ATSDR MRLs:15447329:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b214b7bfaf1737fd2f2da17268b4bba4
ToxValDB_ATSDR_MRLs	MRL	=0.01	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=reproductive in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446849_15446850_15446851:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a08d79e4a0631c7ac0155179832605c5
ToxValDB_ATSDR_MRLs	MRL	=0.001	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=neurological in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446849_15446850_15446851:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b08e399677e3c7ee8b940fcd68cd8554
ToxValDB_ATSDR_MRLs	MRL	=0.01	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=reproductive in male rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446849_15446850_15446851:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a08d79e4a0631c7ac0155179832605c5
ToxValDB_ATSDR_MRLs	MRL	=0.001	mg/kg bw/day	Human	oral	-	Toxicity Value	STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=neurological in male/female rats; STUDY_GROUP=ATSDR MRLs_dup_-_15446849_15446850_15446851:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b08e399677e3c7ee8b940fcd68cd8554
ToxValDB_ATSDR_MRLs	NOAEL	=0.2	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Burek JD, Albee RR, Beyer JE, et al. 1980. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4(5- 6):157-182.; TITLE=Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery; AUTHOR=Burek JD; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447330_15447331:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e4e244a6105b39dabf73f9f1d83d777f
ToxValDB_ATSDR_MRLs	NOAEL (HED)	=0.038	mg/kg bw/day	Rat	oral	subchronic; 90 days	subchronic	LONG_REF=Burek JD, Albee RR, Beyer JE, et al. 1980. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J Environ Pathol Toxicol 4(5- 6):157-182.; TITLE=Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery; AUTHOR=Burek JD; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c03; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp203.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs_dup_-_15447330_15447331:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_52d9e09345c4adc3fcd988d19e8648d2

ToxValDB_ECHA_IUCLID 3 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECHA_IUCLID	NOAEL	>=0.1	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c841e4b0a7c65d2178db; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30137/7/8?documentUUID=934b1d37-5e01-47eb-9a96-c862b6b7a60f; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816087_15816608_15817297_15819682:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_23383d5ada374dd3819da591e68c3886
ToxValDB_ECHA_IUCLID	NOAEL	=0.5	mg/kg bw/day	Rat	oral	-	chronic	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9cee4b0a7c65d1b2d2c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21036/7/8?documentUUID=3cc1f567-2b3a-4d72-914d-a6837b949381; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816087_15816608_15817297_15819682:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b3e67d063fd6b66db9ff94f997c52015
ToxValDB_ECHA_IUCLID	NOAEL	=2	mg/kg bw/day	Rat	oral	-	reproduction developmental	QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba10e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30137/7/9/2?documentUUID=934b1d37-5e01-47eb-9a96-c862b6b7a60f; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID:15857091:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_61f02fcabf56dface1d03bf2695e3dea

ToxValDB_ECOTOX 9 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_ECOTOX	LOEL	=100	mg/kg bw/day	Mouse	oral	acute; 0.25 days	acute	LONG_REF=Mutat. Res.386:315-334 Tice,R.R., J.W. Yager, P. Andrews, and E. Crecelius Effect of Hepatic Methyl Donor Status on Urinary Excretion and DNA Damage in B6C3F1 Mice Treated with Sodium Arsenite 1997; TITLE=Effect of Hepatic Methyl Donor Status on Urinary Excretion and DNA Damage in B6C3F1 Mice Treated with Sodium Arsenite; AUTHOR=Tice,R.R., J.W. Yager, P. Andrews, and E. Crecelius; DOI=10.1016/s1383-5742(97)00004-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=56415; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594426_15597978:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e17603cc37233d51f514a3a28f2f9b6e
ToxValDB_ECOTOX	LOEL	=50	mg/kg bw/day	Mouse	oral	short-term; 3 days	short-term	LONG_REF=Mutat. Res.386:315-334 Tice,R.R., J.W. Yager, P. Andrews, and E. Crecelius Effect of Hepatic Methyl Donor Status on Urinary Excretion and DNA Damage in B6C3F1 Mice Treated with Sodium Arsenite 1997; TITLE=Effect of Hepatic Methyl Donor Status on Urinary Excretion and DNA Damage in B6C3F1 Mice Treated with Sodium Arsenite; AUTHOR=Tice,R.R., J.W. Yager, P. Andrews, and E. Crecelius; DOI=10.1016/s1383-5742(97)00004-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=56415; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594427_15596942:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a1fb16c8be1115fcc584809adae47228
ToxValDB_ECOTOX	LOEL	=0.05	mg/kg bw/day	Rat	oral	short-term; 29 days	developmental	LONG_REF=Environ. Pollut.271:10 p. Zhu,F., J. Wang, J. Jiao, and Y. Zhang Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos 2021; TITLE=Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos; AUTHOR=Zhu,F., J. Wang, J. Jiao, and Y. Zhang; DOI=10.1016/j.envpol.2020.116395; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=185738; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=Embryo: Genetics: Bone morphogenetic protein 4 mRNA|Embryo: Genetics: Runt-related transcription factor 2 mRNA|Embryo: Genetics: Transcription factor SOX-9 mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15612622:F:-embryo; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c80c019e9e8aeabeab9e1f3352ebf247
ToxValDB_ECOTOX	LOEL	=10	mg/kg bw/day	Rat	oral	short-term; 29 days	reproduction developmental	LONG_REF=Environ. Pollut.271:10 p. Zhu,F., J. Wang, J. Jiao, and Y. Zhang Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos 2021; TITLE=Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos; AUTHOR=Zhu,F., J. Wang, J. Jiao, and Y. Zhang; DOI=10.1016/j.envpol.2020.116395; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=185738; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=Reproduction: Fecundity; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15612623:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=bdca2a3753af91f6dd157dcf31182bca
ToxValDB_ECOTOX	LOEL	=5	mg/kg bw/day	Rat	oral	short-term; 21 days	reproduction developmental	LONG_REF=Environ. Pollut.271:10 p. Zhu,F., J. Wang, J. Jiao, and Y. Zhang Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos 2021; TITLE=Exposure to Acrylamide Induces Skeletal Developmental Toxicity in Zebrafish and Rat Embryos; AUTHOR=Zhu,F., J. Wang, J. Jiao, and Y. Zhang; DOI=10.1016/j.envpol.2020.116395; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=185738; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=Hormone(s): Parathyroid hormone (PTH)|Morphology: Density; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX:15612695:F:F1-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=c25ac737b5e566de54e57bceadc30293
ToxValDB_ECOTOX	NOEC	=100	mg/L	Rat	environmental	short-term; 2 days	developmental	LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600569_15600853_15601408_15602726:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f1c694b26cbd7cdf4a2810150e6bc32
ToxValDB_ECOTOX	NOEC	=30	mg/L	Rat	environmental	short-term; 2 days	developmental	LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600569_15600853_15601408_15602726:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=97e8101e163919f346fbe550b0aa6c91
ToxValDB_ECOTOX	NOEC	=10	mg/L	Rat	environmental	short-term; 2 days	developmental	LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600569_15600853_15601408_15602726:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9553acfcfb85adff9e0ec283d595ee26
ToxValDB_ECOTOX	NOEC	=150	mg/L	Rat	environmental	short-term; 2 days	developmental	LONG_REF=Alt. Lab. Anim. (ATLA)32(3): 275-307 Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests 2004; TITLE=Validation of the Postimplantation Rat Whole-Embryo Culture Test in the International ECVAM Validation Study on Three In Vitro Embryotoxicity Tests; AUTHOR=Piersma,A.H., E. Genschow, A. Verhoef, M.Q.I. Spanjersberg, N.A. Brown, M. Brady, A. Burns, N. Clemann, A. Seiler, and; DOI=10.1177/026119290403200307; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=157474; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Deformation; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600569_15600853_15601408_15602726:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82b4ab6578074a809a8f6a352739f600

ToxValDB_EFSA 2 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_EFSA	BMDL (10)	=0.43	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=EFSA CONTAM (2015). Scientific Opinion on acrylamide in food. doi:10.2903/j.efsa.2015.4104.; TITLE=Scientific Opinion on acrylamide in food; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2015.4104; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; STUDY_GROUP=EFSA:15613989:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dd4eacbde5600b301f502ede546cc87b
ToxValDB_EFSA	BMDL (10)	=0.17	mg/kg bw/day	Mouse	oral	chronic; 2 years	chronic	LONG_REF=EFSA CONTAM (2015). Scientific Opinion on acrylamide in food. doi:10.2903/j.efsa.2015.4104.; TITLE=Scientific Opinion on acrylamide in food; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2015.4104; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=histopathology: neoplastic; STUDY_GROUP=EFSA:15613990:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee6e494360e42c9312f3fc2a4882c1c6

ToxValDB_HPVIS 11 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_HPVIS	LOAEL	=2.8	mg/kg bw/day	Rat	oral	subchronic; 80 days	reproduction developmental	LONG_REF=Smith, M.K., Zenick, H., Preston, R.J., George, E.L. and Long, R.E. (1986) Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans rat. Mutat. Res. 173, 273 - 277; TITLE=Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans rat; AUTHOR=Smith, M.K., Zenick, H., Preston, R.J., George, E.L. and Long, R.E; QUALITY=1; EXTERNAL_SOURCE_ID=65122; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Reprotox_15643119_15643324:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_61ce096023c40dcee411de23e6cd3ceb
ToxValDB_HPVIS	NOAEL	=5	mg/kg bw/day	Rat	oral	subchronic; 13 weeks	subchronic	LONG_REF=Tilson, H.A. and Cabe, P.A. (1979a) The effects of acrylamide given acutely or in repeated doses on fore- and hindlimb function of rats. Toxicol. Appl. Pharm. 47, 253 - 260; TITLE=The effects of acrylamide given acutely or in repeated doses on fore- and hindlimb function of rats; AUTHOR=Tilson, H.A. and Cabe, P.A; QUALITY=1; EXTERNAL_SOURCE_ID=63694; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1979; ORIGINAL_YEAR=1979; STUDY_GROUP=HPVIS:15639433:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_01373e4ac747b13a054bded5176297e8
ToxValDB_HPVIS	NOAEL	=0.2	mg/kg bw/day	Rat	oral	chronic; 93 days	chronic	LONG_REF=Burek, J.D., Albee, R.R., Beyer, J.E., Bell, T.J., Carreon, R.M., Morden, D.C., Wade, C.E., Hermann, E.A., Gorzinski, S.J. (1980) Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J. Environm. Path. Toxicol. 4, 157 - 182; TITLE=Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery; AUTHOR=Burek, J.D., Albee, R.R., Beyer, J.E., Bell, T.J., Carreon, R.M., Morden, D.C., Wade, C.E., Hermann, E.A., Gorzinski, S.J; QUALITY=1; EXTERNAL_SOURCE_ID=61353; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=HPVIS:15639736:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a2df174da224b005407de21aaa73c357
ToxValDB_HPVIS	NOAEL	=15	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=Field, E., Price, C.J., Sleet, R.B., Marr, M.C., Schwetz, B.A. and Morrissey, R.E. (1990) Developmental toxicity evaluation of acrylamide in rats and mice. Fundamental and Applied Toxicology 14, 502-512; TITLE=Developmental toxicity evaluation of acrylamide in rats and mice; AUTHOR=Field, E., Price, C.J., Sleet, R.B., Marr, M.C., Schwetz, B.A. and Morrissey, R.E; QUALITY=1; EXTERNAL_SOURCE_ID=57901; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; STUDY_GROUP=HPVIS:15642289:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b36287851d1598c7aef62df2a7c8a034
ToxValDB_HPVIS	NOAEL	=2.5	mg/kg bw/day	Rat	oral	-	developmental	LONG_REF=Field, E., Price, C.J., Sleet, R.B., Marr, M.C., Schwetz, B.A. and Morrissey, R.E. (1990) Developmental toxicity evaluation of acrylamide in rats and mice. Fundamental and Applied Toxicology 14, 502-512; TITLE=Developmental toxicity evaluation of acrylamide in rats and mice; AUTHOR=Field, E., Price, C.J., Sleet, R.B., Marr, M.C., Schwetz, B.A. and Morrissey, R.E; QUALITY=1; EXTERNAL_SOURCE_ID=59863; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=maternal toxicity; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=HPVIS:15642894:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_84fe863b0600f7fce0d07408ce3fec0e
ToxValDB_HPVIS	NOAEL	=0.5	mg/kg bw/day	Rat	oral	subchronic; 10 weeks	reproduction developmental	LONG_REF=Johnson, K.A., Gorzinski, S.J., Bodner, K.M. and Campbell, P.A. (1984) Acrylamide: A two year drinking water chronic toxicity-oncogenicity study in Fischer 344 rats. Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences, USA,Dow Chemcial USA, Final Report, September 21, 1984.; TITLE=Acrylamide: A two year drinking water chronic toxicity-oncogenicity study in Fischer 344 rats; AUTHOR=Johnson, K.A., Gorzinski, S.J., Bodner, K.M. and Campbell, P.A; QUALITY=2; EXTERNAL_SOURCE_ID=65120; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Reprotox_15643117_15643118:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_07124183d5e2738101c9bf17f4ff04de
ToxValDB_HPVIS	NOAEL	=1.5	mg/kg bw/day	Rat	oral	subchronic; 80 days	reproduction developmental	LONG_REF=Smith, M.K., Zenick, H., Preston, R.J., George, E.L. and Long, R.E. (1986) Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans rat. Mutat. Res. 173, 273 - 277; TITLE=Dominant lethal effects of subchronic acrylamide administration in the male Long-Evans rat; AUTHOR=Smith, M.K., Zenick, H., Preston, R.J., George, E.L. and Long, R.E; QUALITY=1; EXTERNAL_SOURCE_ID=65792; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480598; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1986; ORIGINAL_YEAR=1986; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Reprotox_15643119_15643324:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f6dd9689f5e0c0a82a53220f12d8eda2
ToxValDB_HPVIS	NOAEL	>=4.1	mg/kg bw/day	Rat	oral	short-term; 28 days	short-term	LONG_REF=Keefe, R.T. (1991) 28-day subchronic toxicity study in rats. EXXON Biomedical Sciences,Inc. No. 234870, Final Report April 2, 1991; TITLE=28-day subchronic toxicity study in rats. EXXON Biomedical Sciences,Inc. No. 234870, Final Report April 2, 1991; AUTHOR=Keefe, R.T; QUALITY=1; EXTERNAL_SOURCE_ID=60814; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643474_15643683:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_46b435395b32ab0326846df0d3bc7f62
ToxValDB_HPVIS	NOAEL	>=1	mg/kg bw/day	Monkey	oral	chronic; 363 days	chronic	LONG_REF=McCollister, D.D., Oven, F. and Rowe, V.K. (1964) Toxicology of acrylamide. Toxicol. Appl. Pharmacol. 6, 172 - 181; TITLE=Toxicology of acrylamide; AUTHOR=McCollister, D.D., Oven, F. and Rowe, V.K; QUALITY=2; EXTERNAL_SOURCE_ID=61869; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1964; ORIGINAL_YEAR=1964; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643480_15643689:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_36af8ff3cb81b9b154158354de09f3f5
ToxValDB_HPVIS	NOAEL	<=4.3	mg/kg bw/day	Rat	oral	short-term; 28 days	short-term	LONG_REF=Keefe, R.T. (1991) 28-day subchronic toxicity study in rats. EXXON Biomedical Sciences,Inc. No. 234870, Final Report April 2, 1991; TITLE=28-day subchronic toxicity study in rats. EXXON Biomedical Sciences,Inc. No. 234870, Final Report April 2, 1991; AUTHOR=Keefe, R.T; QUALITY=1; EXTERNAL_SOURCE_ID=60814; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643474_15643683:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_64eea89a25fc1983eae644835d7f7cdf
ToxValDB_HPVIS	NOAEL	<=3	mg/kg bw/day	Monkey	oral	chronic; 363 days	chronic	LONG_REF=McCollister, D.D., Oven, F. and Rowe, V.K. (1964) Toxicology of acrylamide. Toxicol. Appl. Pharmacol. 6, 172 - 181; TITLE=Toxicology of acrylamide; AUTHOR=McCollister, D.D., Oven, F. and Rowe, V.K; QUALITY=2; EXTERNAL_SOURCE_ID=61869; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1964; ORIGINAL_YEAR=1964; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15643480_15643689:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7095b718361b34234965038cd35e9a3b

ToxValDB_IRIS 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_IRIS	BMDL (05)	=0.27	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol, 85: 154-168.; TITLE=Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats; AUTHOR=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5455; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; TOXICOLOGICAL_EFFECT=degenerative nerve changes; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644276_15644277:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9b99a8070c3ad3ffd993be0fb7d3691e
ToxValDB_IRIS	BMDL (HEC)	=0.18	mg/m3	Rat	inhalation	-	chronic	LONG_REF=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol, 85: 154-168.; TITLE=Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats; AUTHOR=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5455; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; TOXICOLOGICAL_EFFECT=degenerative nerve changes; STUDY_GROUP=IRIS:15644224:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1020c44a8860a9b5dae1f3bd7305a02e
ToxValDB_IRIS	BMDL (HED)	=0.053	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol, 85: 154-168.; TITLE=Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats; AUTHOR=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5455; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; TOXICOLOGICAL_EFFECT=degenerative nerve changes; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644276_15644277:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1a158a022b22e33bd34df0ca7cc3a367
ToxValDB_IRIS	RfC	=0.006	mg/m3	Human	inhalation	-	Toxicity Value	LONG_REF=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol, 85: 154-168.; TITLE=Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats; AUTHOR=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5455; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; TOXICOLOGICAL_EFFECT=Degenerative nerve changes in male/female rats; STUDY_GROUP=IRIS:15644225:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_70e7d1c9b68d5e99e5aec2d75b060fad
ToxValDB_IRIS	RfD	=0.002	mg/kg bw/day	Human	oral	-	Toxicity Value	LONG_REF=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW (1986). Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol Appl Pharmacol, 85: 154-168.; TITLE=Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats; AUTHOR=Johnson KA; Gorzinski SJ; Bodner KM; Campbell RA; Wolf CH; Friedman MA; Mast RW; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a5455; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=286; TOXICOLOGICAL_EFFECT=Degenerative nerve changes in male/female rats; STUDY_GROUP=IRIS:15644223:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13e0105f62f5fa88e9b52f854116a76b

ToxValDB_WHO_JECFA_Tox_Studies 5 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
ToxValDB_WHO_JECFA_Tox_Studies	BMDL (10)	=0.31	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Beland FA (2010). Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats. Unpublished study. Submitted to FAO/WHO by the United States National Center for Toxicological Research, Jefferson, AK.; TITLE=Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats; AUTHOR=Beland FA (2010). Technical report for experiment No; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875aa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5198; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15715873_15715875_15715876:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ffcb43d86d08f554370c55281824df8a
ToxValDB_WHO_JECFA_Tox_Studies	BMDL (10)	=0.18	mg/kg bw/day	Mouse	oral	chronic; 2 years	chronic	LONG_REF=Beland FA (2010). Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats. Unpublished study. Submitted to FAO/WHO by the United States National Center for Toxicological Research, Jefferson, AK.; TITLE=Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats; AUTHOR=Beland FA (2010). Technical report for experiment No; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875aa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5198; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Hardarian gland & lung tumors (males); TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15715874_15715877:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a816e76ae15a0098c7e4ff22a8a86d99
ToxValDB_WHO_JECFA_Tox_Studies	LOEL	=1.05	mg/kg bw/day	Mouse	oral	chronic; 2 years	chronic	LONG_REF=Beland FA (2010). Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats. Unpublished study. Submitted to FAO/WHO by the United States National Center for Toxicological Research, Jefferson, AK.; TITLE=Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats; AUTHOR=Beland FA (2010). Technical report for experiment No; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875aa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5198; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=Hardarian gland & lung tumors (males); TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15715874_15715877:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7e2c098088e875391d8b2f42afc0b82a
ToxValDB_WHO_JECFA_Tox_Studies	NOAEL	=0.67	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Beland FA (2010). Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats. Unpublished study. Submitted to FAO/WHO by the United States National Center for Toxicological Research, Jefferson, AK.; TITLE=Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats; AUTHOR=Beland FA (2010). Technical report for experiment No; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875aa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5198; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15715873_15715875_15715876:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e84de156e6d6393c897f9fe469b13e0b
ToxValDB_WHO_JECFA_Tox_Studies	NOAEL	=1.88	mg/kg bw/day	Rat	oral	chronic; 2 years	chronic	LONG_REF=Beland FA (2010). Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats. Unpublished study. Submitted to FAO/WHO by the United States National Center for Toxicological Research, Jefferson, AK.; TITLE=Technical report for experiment No. 2150.05 and 2150.07. Genotoxicity and carcinogenicity of acrylamide and its metabolite, glycidamide, in rodents: two year chronic study of acrylamide in B6C3F1 mice and F334 rats; AUTHOR=Beland FA (2010). Technical report for experiment No; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650af6c3e4b0d99f5a875aa5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5198; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15715873_15715875_15715876:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_169c863398a1ae2fa1e3c1ade5aafaee

openFDA substances 4 endpoints

Source	Endpoint Type	Value	Unit	Species	Route	Duration	Study Type	Reference
openFDA substances	FDA UNII substance identifier	20R035KLCI	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C3H5NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"20R035KLCI"}
openFDA substances	FDA UNII substance identifier	20R035KLCI	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C3H5NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"20R035KLCI"}
openFDA substances	FDA UNII substance identifier	20R035KLCI	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C3H5NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"20R035KLCI"}
openFDA substances	FDA UNII substance identifier	20R035KLCI	UNII	-	-	-	chemical	{"approval_status":null,"molecular_formula":"C3H5NO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"20R035KLCI"}