NOAEL Studies
Cosmetic Ingredient
ACRYLIC ACID NOAEL Studies
CAS: 79-10-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL (HEC) | =0.33 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=ed4404214f19e49a; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=LOAEL (HEC): 3.3e-1 mg/m^3; system=Nervous, Respiratory; basis=Degeneration of the nasal olfactory epithelium; point_of_departure=LOAEL (HEC): 3.3e-1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID0039229; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; rfc_last_updated=04/01/1994; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0002_summary.pdf |
| Regulatory source | RfC | =0.001 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=217ed4063f432290; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1e-3; system=Nervous, Respiratory; basis=Degeneration of the nasal olfactory epithelium; point_of_departure=LOAEL (HEC): 3.3e-1 mg/m^3; composite_uf=300; confidence=Medium; dtxsid=DTXSID0039229; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; rfc_last_updated=04/01/1994; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0002_summary.pdf |
| Regulatory source | NOAEL | =53 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=3de09fd5ec2f790b; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 5.3e1 mg/kg-day; system=Developmental; basis=Reduced pup weight; point_of_departure=NOAEL : 5.3e1 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID0039229; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; rfd_last_updated=04/01/1994; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0002_summary.pdf |
| Regulatory source | RfD | =0.5 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=2c01a319acfe8a6b; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-1; system=Developmental; basis=Reduced pup weight; point_of_departure=NOAEL : 5.3e1 mg/kg-day; composite_uf=100; confidence=High; dtxsid=DTXSID0039229; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; rfd_last_updated=04/01/1994; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0002_summary.pdf |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | - |
WHO/JECFA 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =15 | mg/m3 | - | inhalation | subchronic | Chronic toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=b5a94ea105524395; raw_unit=mg/m 3; context=10.1.4 Risk evaluation 10.1.4.1 Inhalation exposure The LOAEL of 15 mg/m 3 (5 ppm) from the subchronic study is used as the basis for the guidance value. |
| WHO/JECFA | NOAEL | =78 | mg/kg bw/day | - | oral | 12-month | Reproductive toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=f77c7be82856a15e; raw_unit=mg/kg body weight; context=V can be calculated based on NOAEL values in the 12-month oral study (140 mg/kg body weight per day), the two- generation reproductive study (240 mg/kg body weight per day) or the NOAEL in the chronic study (78 mg/kg body weight day). |
| WHO/JECFA | NOAEL | =140 | mg/kg bw/day | Rat; Mouse | inhalation | 12-month | Chronic toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=608fe1872b128363; raw_unit=mg/kg body weight per day; context=The NOAEL based on body weight changes in the 12-month studies was 140 mg/kg body weight per day. e) Critical inhalation studies In a subchronic study, which is the only study that is potentially a critical study for inhalation, lesions in the nasal epithelium were seen in rats at 225 mg/m 3 (75 ppm) and in mice at 15 mg/m 3 (5 ppm). |
| WHO/JECFA | NOAEL | =140 | mg/kg bw | Rat | - | - | Toxicology study | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=ba1479c6ac4e936d; raw_unit=mg/kg; context=Lors d'études au cours desquelles des rats ont absorbé de l'acide acrylique dans leur eau de boisson, on a constaté que la dose sans effet nocif observable (NOAEL) était de 140 mg/kg de poids corporel par jour, le critère retenu étant la réduction du gain de poids sur 12 mois, et de 240 mg/kg de poids corporel par jour, la critère retenu dans ce cas étant la présence d'anomalies histologiques au niveau de l'estomac. |
| WHO/JECFA | NOAEL | =240 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=2484accdea59c073; raw_unit=mg/kg body weight per day; context=Based on these considerations and the presence of stomach histopathology at 460 mg/kg body weight per day, the NOAEL in the two- generation reproduction study was 240 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =331 | mg/kg bw/day | - | - | 12-month | Reproductive toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=7162ab6d1af438dc; raw_unit=mg/kg body weight per day; context=The NOAEL is supported by the finding of adverse effects on body weight at 331 mg/kg body weight per day in the 12-month study and body weight effects and stomach pathology in the two-generation reproductive study at 460 mg/kg body weight per day. |
| WHO/JECFA | NOAEL | =1080 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=3e32685bb7b3205f; raw_unit=mg/m 3; context=This study identified a NOAEL for developmental effects of 1080 mg/m 3 and a LOAEL for maternal toxicity of 1080 mg/m 3 . |
| WHO/JECFA | NOEL | =25 | ppm | Mouse | inhalation | 5 days | Inhalation toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=bf38805cdcc44471; raw_unit=ppm; context=(contd.) Species, route and dosage LOEL a NOEL a Observed effects Reference Mouse, B6C3F 1 25 ppm Decrease in body weight Miller et al., inhalation, 0, 25, 74, (75 mg/m 3 ) gain, lesions in nasal 1979 223 ppm, 6 h/day mucosa 5 days/week for 2 weeks Mouse, B6C3F inhalation 5 ppm 5 ppm Atrophy, disorganization, Lomax et al., 0, 5, 25 ppm for 6 or 22 22 h/da |
| WHO/JECFA | NOEL | =53 | mg/kg bw/day | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=2dab8cd8a32661a8; raw_unit=mg/kg per day; context=Thus, 500 mg/litre (equivalent to 53 mg/kg per day) was a NOEL for both generations of offspring and also a NOAEL for general toxicity in the second parental generation. |
| WHO/JECFA | NOEL | =78 | mg/kg bw/day | Rat | inhalation | - | Carcinogenicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=5eb606fb345e56b1; raw_unit=mg/kg bw/day; context=(contd.) Species, route and dosage LOEL a NOEL a Observed effects Reference Rat, Wistar, oral, 78 mg/kg bw/day No treatment-related Hellwig et al., drinking-water, 0, 8, 27, toxic effects including 1993 78 mg/kg body tumorogenicity weight/day for 26 (males) or 28 (females) months Rat, inhalation, 80, 300 300 ppm 80 ppm Nose irritation, lethargy Gage, 1970 ppm, 6 h/day |
| WHO/JECFA | NOEL | =250 | mg/kg bw/day | Rat | oral | 3 months | Carcinogenicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=6d5fb6c14826f53f; raw_unit=mg/kg bw/day; context=Key studies on the noncarcinogenic effects of repeated exposures to acrylic acid Species, route and dosage LOEL a NOEL a Observed effects Reference Rat, Fisher-344 oral, 250 mg/kg bw/day 83 mg/kg bw/day Decreased body weight, De Pass et al., drinking-water, 0, 83, reduced water and food 1983 250, 750 mg/kg body consumption, changes in weight/day for 3 months organ weights Rat, Wistar, gavage, 0, 150 mg/kg bw/day 50% mortality in both Hellwig |
| WHO/JECFA | NOEL | =675 | mg/m3 | - | - | - | Developmental toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=8b2ad96fa95ecc3b; raw_unit=mg/m 3; context=This study identified a NOEL for developmental effects of 675 mg/m 3 . |
| WHO/JECFA | NOEL | =2500 | mg/L | - | - | - | Reproductive toxicity | document_id=ehc_ehc_ehc191; title=Acrylic acid (EHC 191, 1997); path=mirror/documents/ehc/ehc/ehc191.htm; row_hash=5848ac648db28eef; raw_unit=mg/litre; context=The NOEL for general toxicity in the first parental generation was 2500 mg/litre (equivalent to 240 mg/kg per day). |
| WHO/JECFA | LOAEL | =15 | mg/m3 | Mouse | inhalation | 90 days | Subchronic toxicity | document_id=hsg_hsg_v104hsg; title=Acrylic acid (HSG 104, 1997); path=mirror/documents/hsg/hsg/v104hsg.htm; row_hash=10712ee76eb1a68c; raw_unit=mg/m 3; context=For inhalation studies a lowest-observed- adverse-effect level (LOAEL) of 15 mg/m 3 (5 ppm) was observed in mice exposed to acrylic acid for 90 days, based on very mild nasal lesions in females at this level. |
NTP ICE acute inhalation 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.879 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=578; Record_ID=acute_inhalation_2249; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.879; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 1.283 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=580; Record_ID=acute_inhalation_2245; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.283; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 1.884 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=582; Record_ID=acute_inhalation_2239; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.884; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 3.5346 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=575; Record_ID=acute_inhalation_2255; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.5346; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 3.6 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=576; Record_ID=acute_inhalation_2253; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=3.6; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | >4.31 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=577; Record_ID=acute_inhalation_2701; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=4.31; Response_Unit=mg/L; mg/L air (analytical); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | >5.1 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=573; Record_ID=acute_inhalation_722; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15803/7/3/3/?documentUUID=a09926ae-850e-4408-bf6b-7055ef6843a9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | >6.74 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=574; Record_ID=acute_inhalation_2700; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=6.74; Response_Unit=mg/L; mg/L air (analytical); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 7.7644 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=572; Record_ID=acute_inhalation_2251; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.7644; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 11.3403 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=579; Record_ID=acute_inhalation_2247; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.3403; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE acute inhalation | LC50 | 16.6481 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=581; Record_ID=acute_inhalation_2241; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=16.6481; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=996; Record_ID=cancer_4120; Data_Type=WOE; Formulation_Name=Acrylic acid; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/37; http://publications.iarc.fr/139; http://publications.iarc.fr/89; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
NTP ICE skin irritation 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 28 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=635; Record_ID=skin_irritation_invitro_28; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Corrositex; Endpoint=Breakthrough Time; Response=28; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Breakthrough Time | 29 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=633; Record_ID=skin_irritation_invitro_30; Data_Type=In Vitro; Concentration=99; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=Corrositex; Endpoint=Breakthrough Time; Response=29; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | TER | 1.3 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=676; Record_ID=skin_irritation_invitro_2468; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=TER Corrosion; Endpoint=TER; Response=1.3; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (240 minutes) | 2.9 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=673; Record_ID=skin_irritation_invitro_1847; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=2.9; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (240 minutes) | 3.2 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=675; Record_ID=skin_irritation_invitro_1845; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (240 minutes) | 3.4 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=674; Record_ID=skin_irritation_invitro_1846; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=3.4; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | -1.1 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=643; Record_ID=skin_irritation_invitro_1862; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=-1.10; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 0.5 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=639; Record_ID=skin_irritation_invitro_1866; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=0.5; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 1.2 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=646; Record_ID=skin_irritation_invitro_1870; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=1.2; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 1.5 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=648; Record_ID=skin_irritation_invitro_1868; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=1.5; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 1.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=661; Record_ID=skin_irritation_invitro_1845; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=1.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 1.9 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=642; Record_ID=skin_irritation_invitro_1874; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (3 minutes); Response=1.9; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 2 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=650; Record_ID=skin_irritation_invitro_1852; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=2; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.4 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=651; Record_ID=skin_irritation_invitro_1850; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=2.4; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.6 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=645; Record_ID=skin_irritation_invitro_1860; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=2.6; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=659; Record_ID=skin_irritation_invitro_1847; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=2.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 2.9 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=654; Record_ID=skin_irritation_invitro_1856; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=2.9; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 3.1 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=647; Record_ID=skin_irritation_invitro_1858; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=3.1; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 3.3 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=655; Record_ID=skin_irritation_invitro_1849; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=3.3; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 3.7 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=658; Record_ID=skin_irritation_invitro_1848; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=3.7; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 4.4 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=641; Record_ID=skin_irritation_invitro_1864; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (3 minutes); Response=4.40; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 4.8 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=640; Record_ID=skin_irritation_invitro_1877; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (3 minutes); Response=4.8; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (3 minutes) | 14.5 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=638; Record_ID=skin_irritation_invitro_1882; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (3 minutes); Response=14.5; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 0.2 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=693; Record_ID=skin_irritation_invitro_1872; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (60 minutes); Response=0.2; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 0.3 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=690; Record_ID=skin_irritation_invitro_1866; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=0.3; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 0.4 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=692; Record_ID=skin_irritation_invitro_1870; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=0.4; Response_Unit=%; Reference=Tornier et al. 2010; 20471469; 10.1016/j.tiv.2010.05.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 0.9 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=670; Record_ID=skin_irritation_invitro_1882; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (60 minutes); Response=0.9; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 1.1 | % | - | Dermal | - | In Vitro; LabCyte Corrosion | sheet=Data_invitro; excel_row=669; Record_ID=skin_irritation_invitro_1877; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=LabCyte Corrosion; Endpoint=Viability (60 minutes); Response=1.10; Response_Unit=%; Reference=Katoh et al. 2010; 20519850; 10.2131/jts.35.411; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 1.8 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=681; Record_ID=skin_irritation_invitro_1849; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=1.8; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 1.9 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=682; Record_ID=skin_irritation_invitro_1850; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=1.9; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 2.5 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=679; Record_ID=skin_irritation_invitro_1847; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=2.5; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 2.7 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=668; Record_ID=skin_irritation_invitro_1845; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=2.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 2.8 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=685; Record_ID=skin_irritation_invitro_1856; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=2.8; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 3 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=684; Record_ID=skin_irritation_invitro_1854; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=3; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 3.6 | % | - | Dermal | - | In Vitro; SkinEthic Corrosion | sheet=Data_invitro; excel_row=680; Record_ID=skin_irritation_invitro_1848; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=SkinEthic Corrosion; Endpoint=Viability (60 minutes); Response=3.6; Response_Unit=%; Reference=Kandarova et al. 2006; 16455230; 10.1016/j.tiv.2005.11.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
| NTP ICE skin irritation | Viability (60 minutes) | 3.8 | % | - | Dermal | - | In Vitro; EpiSkin Corrosion | sheet=Data_invitro; excel_row=678; Record_ID=skin_irritation_invitro_1846; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID0039229; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=3.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0039229; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0039229 |
ToxValDB Cal OEHHA REL derivations 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | NOAEL | =235.79 | mg/m3 | Rat | inhalation | short-term; 20 days | short-term | LONG_REF=Gage JC. The subacute inhalation toxicity of 109 industrial chemicals. Br J Ind Med 1970; 27:118.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=nasal irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951900:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_77fdcf244048734cdc17cb5a59cf917b |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =70737 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=DOE Protective Action Criteria:15511841:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_00d11619f0aee6add5fffaa46405e487 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =150 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd6f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22071/7/6/2?documentUUID=d13d71e3-65c5-4b1c-bf06-d17c5394d99a; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15831659:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ca1fc0867ab0660fe0df29afc6c4f79 |
| ECHA | LOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd705; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22071/7/6/2?documentUUID=d13d71e3-65c5-4b1c-bf06-d17c5394d99a; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834945_15834946:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d2dcfd3fbe191c5237ef2f077815a1c5 |
| ECHA | NOAEL | =83 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf51e4b0a7c65d1cd705; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/22071/7/6/2?documentUUID=d13d71e3-65c5-4b1c-bf06-d17c5394d99a; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834945_15834946:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b1b65de7d32c87d0a0db08095dcb2052 |
ToxValDB ECOTOX 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =0.6 | % | Rat | oral | acute; 1 days | acute | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601809_15601810:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=301b712a046627e49eaf6057eaafda36 |
| ToxValDB ECOTOX | LOEL | =4 | % | Mouse | dermal | subchronic; 56 days | subchronic | LONG_REF=Food Chem. Toxicol.33(6): 507-513 McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid 1995; TITLE=Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid; AUTHOR=McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy; DOI=10.1016/0278-6915(95)00011-p; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=151653; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605219_15605220:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d6dcd6fee34197fadf56269bec79f7e9 |
| ToxValDB ECOTOX | LOEL | =8 | % w/v | Rat | oral | acute; 0.0417 days | acute | LONG_REF=Fundam. Appl. Toxicol.8(4): 549-561 DeBethizy,J.D., J.R. Udinsky, H.E. Scribner, and C.B. Frederick The Disposition and Metabolism of Acrylic Acid and Ethyl Acrylate in Male Sprague-Dawley Rats 1987; TITLE=The Disposition and Metabolism of Acrylic Acid and Ethyl Acrylate in Male Sprague-Dawley Rats; AUTHOR=DeBethizy,J.D., J.R. Udinsky, H.E. Scribner, and C.B. Frederick; DOI=10.1016/0272-0590(87)90140-0; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=151701; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Biochemistry: Nonprotein sulfhydryl; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606574_15606575:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=75c2427163aa59bb50b3e6ede60ebde2 |
| ToxValDB ECOTOX | LOEL | =100 | ul/org | Mouse | dermal | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc. #89-910000139s:1460 p. EPA/OTS Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized) 1990; TITLE=Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized); AUTHOR=EPA/OTS; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=152047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597459_15597460:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05b7eeebbf2b758f77115aae5fa1e224 |
| ToxValDB ECOTOX | LOEL | =730 | mg/L | Rat | oral | chronic; 21 weeks | chronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611251_15611252_15611518_15611520:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a5fc32bd689107f654189dbf977ee283 |
| ToxValDB ECOTOX | LOEL | =5000 | mg/L | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=Food Chem. Toxicol.31(1): 1-18 Hellwig,J., K. Deckardt, and K.O. Freisberg Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats 1993; TITLE=Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats; AUTHOR=Hellwig,J., K. Deckardt, and K.O. Freisberg; DOI=10.1016/0278-6915(93)90172-u; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Cell(s): Red blood cell; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598016_15598017:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=82d4d395440362356e409975b6ce0bfa |
| ToxValDB ECOTOX | NOEL | =0.08 | % w/v | Rat | oral | acute; 0.0417 days | acute | LONG_REF=Fundam. Appl. Toxicol.8(4): 549-561 DeBethizy,J.D., J.R. Udinsky, H.E. Scribner, and C.B. Frederick The Disposition and Metabolism of Acrylic Acid and Ethyl Acrylate in Male Sprague-Dawley Rats 1987; TITLE=The Disposition and Metabolism of Acrylic Acid and Ethyl Acrylate in Male Sprague-Dawley Rats; AUTHOR=DeBethizy,J.D., J.R. Udinsky, H.E. Scribner, and C.B. Frederick; DOI=10.1016/0272-0590(87)90140-0; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=151701; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Biochemistry: Nonprotein sulfhydryl; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606574_15606575:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2b2ad23cf42780aeb34b4d8262073bb9 |
| ToxValDB ECOTOX | NOEL | =0.2 | mg/org | Mouse | dermal | chronic; 850 days | chronic | LONG_REF=J. Toxicol. Environ. Health14:115-120 DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate 1984; TITLE=Dermal Oncogenicity Bioassays of Acrylic Acid, Ethyl Acrylate, and Butyl Acrylate; AUTHOR=DePass,L.R., E.H. Fowler, D.R. Meckley, and C.S. Weil; DOI=10.1080/15287398409530566; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91232; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Injury: Tumor induction|Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival; STUDY_GROUP=ECOTOX:15611146:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44deb7abdc79f902cd92db73da1698b7 |
| ToxValDB ECOTOX | NOEL | =0.3 | % | Rat | oral | acute; 1 days | acute | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601809_15601810:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=86f5da489fe092a8cbc1a6d5c5b793f0 |
| ToxValDB ECOTOX | NOEL | =0.6 | % | Rat | oral | short-term; 7 days | short-term | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15605180:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=08d89d2014a2868b8ee0c3722f2b7bb8 |
| ToxValDB ECOTOX | NOEL | =1 | % | Mouse | dermal | subchronic; 56 days | subchronic | LONG_REF=Food Chem. Toxicol.33(6): 507-513 McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid 1995; TITLE=Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid; AUTHOR=McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy; DOI=10.1016/0278-6915(95)00011-p; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=151653; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605219_15605220:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e228fc7f6452427897153dde822b67c5 |
| ToxValDB ECOTOX | NOEL | =4 | % | Mouse | dermal | chronic; 91 days | chronic | LONG_REF=Food Chem. Toxicol.33(6): 507-513 McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid 1995; TITLE=Comparison of the Maximum Tolerated Dose (MTD) Dermal Response in Three Strains of Mice Following Repeated Exposure to Acrylic Acid; AUTHOR=McLaughlin,J.E., J. Parno, F.M. Garner, J.J. Clary, W.C. Thomas, and S.R. Murphy; DOI=10.1016/0278-6915(95)00011-p; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=151653; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15606111:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=66c3509463666d08c2ad7fc3089c123a |
| ToxValDB ECOTOX | NOEL | =10 | % | Mouse | dermal | short-term; 10 days | short-term | LONG_REF=EPA/OTS Doc. #86-890001491S:18 p. Carneigie-Mellon Institute of Research Letter from Carnegie-Mellon Inst of Research Concerning Results of the 2-Week Preliminary Skin Dosing of Acrylic Acid & Ethyl Acrylate with Attached, Cover Sheets (Sanitized) 1989; TITLE=Letter from Carnegie-Mellon Inst of Research Concerning Results of the 2-Week Preliminary Skin Dosing of Acrylic Acid & Ethyl Acrylate with Attached, Cover Sheets (Sanitized); AUTHOR=Carneigie-Mellon Institute of Research; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=152050; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15607904:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4f1ea775b09671b36518e1c54ef48783 |
| ToxValDB ECOTOX | NOEL | =25 | ul/org | Mouse | dermal | short-term; 7 days | short-term | LONG_REF=EPA/OTS Doc. #89-910000139s:1460 p. EPA/OTS Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized) 1990; TITLE=Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized); AUTHOR=EPA/OTS; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=152047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597459_15597460:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=46eb7e628c708831a53ecfbd84da5c4c |
| ToxValDB ECOTOX | NOEL | =27 | mg/kg bw/day | Rat | oral | chronic; 365.28 days | chronic | LONG_REF=Food Chem. Toxicol.31(1): 1-18 Hellwig,J., K. Deckardt, and K.O. Freisberg Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats 1993; TITLE=Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats; AUTHOR=Hellwig,J., K. Deckardt, and K.O. Freisberg; DOI=10.1016/0278-6915(93)90172-u; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Biochemistry: Mean corpuscular hemoglobin; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599876_15599877:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7b264e0b268122437c6a10f5daedb3e9 |
| ToxValDB ECOTOX | NOEL | =78 | mg/kg bw/day | Rat | oral | chronic; 791.44 days | chronic | LONG_REF=Food Chem. Toxicol.31(1): 1-18 Hellwig,J., K. Deckardt, and K.O. Freisberg Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats 1993; TITLE=Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats; AUTHOR=Hellwig,J., K. Deckardt, and K.O. Freisberg; DOI=10.1016/0278-6915(93)90172-u; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Cell(s): Thrombocytes|Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|hematology; STUDY_GROUP=ECOTOX:15594925:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c900e5bf677d1ca96dabcd9ed2644984 |
| ToxValDB ECOTOX | NOEL | =83 | mg/L | Rat | oral | chronic; 21 weeks | chronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611303_15611304_15611332:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4cbf2c5cfbeea7129fbd11455b6e845b |
| ToxValDB ECOTOX | NOEL | =84 | mg/L | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Biochemistry: Cholesterol|Enzyme(s): Alkaline phosphatase|Feeding behavior: Water consumption|Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595269_15595270:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4945b9b10be990cf1d0ebf5987b29c02 |
| ToxValDB ECOTOX | NOEL | =85 | mg/L | Rat | oral | chronic; 21 weeks | chronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611251_15611252_15611518_15611520:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0dd7213cd008d4af9a172a9711e5781f |
| ToxValDB ECOTOX | NOEL | =100 | ul/org | Mouse | dermal | chronic; 623 days | chronic | LONG_REF=EPA/OTS Doc. #89-910000139s:1460 p. EPA/OTS Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized) 1990; TITLE=Support Document: Chronic Dermal Oncogenicity Study with Acrylic Acid in [C3H/HeN HsD BR] and [HsD: (ICR) BR] Mice with Letter 010491 ((Binder I-VI) (Project Report) (Sanitized); AUTHOR=EPA/OTS; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=152047; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Cell(s): Hematopoiesis|Histology: Dilation|Injury: Adenoma|Physiology: Minerialization; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594642_15603486_15603487_15605766:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e38fce4afb6da22bc2f21d4ad5985ae1 |
| ToxValDB ECOTOX | NOEL | >178.4 | mg/kg bw/day | Rat | oral | chronic; 365.28 days | chronic | LONG_REF=Food Chem. Toxicol.31(1): 1-18 Hellwig,J., K. Deckardt, and K.O. Freisberg Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats 1993; TITLE=Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats; AUTHOR=Hellwig,J., K. Deckardt, and K.O. Freisberg; DOI=10.1016/0278-6915(93)90172-u; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Histology: Histological changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15611011:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e9c4bbc664281fa3511a333c486a7a61 |
| ToxValDB ECOTOX | NOEL | =250 | mg/L | Rat | oral | chronic; 21 weeks | chronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611251_15611252_15611518_15611520:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c7632f8e19d81e24c7d64e17f408924a |
| ToxValDB ECOTOX | NOEL | =365.25 | mg/kg bw/day | Rat | oral | chronic; 91.32 days | chronic | LONG_REF=EPA/OTS Doc. #88-920009570:75 p. BASF Aktiengesellschaft Initial Submission: Report on the Study of the Toxicity of Acrylic Acid in Rats After 3-Month Administration by Gavage with Cover Letter Dated 081092 1992; TITLE=Initial Submission: Report on the Study of the Toxicity of Acrylic Acid in Rats After 3-Month Administration by Gavage with Cover Letter Dated 081092; AUTHOR=BASF Aktiengesellschaft; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151659; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Growth: Weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15610799:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4ea6f7f3c28bb1d7ff17b46279d42600 |
| ToxValDB ECOTOX | NOEL | =740 | mg/L | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Drug Chem. Toxicol.6(1): 1-20 DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat 1983; TITLE=Subchronic and Reproductive Toxicology Studies on Acrylic Acid in the Drinking Water of the Rat; AUTHOR=DePass,L.R., M.D. Woodside, R.H. Garman, and C.S. Weil; DOI=10.3109/01480548309072459; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151682; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Enzyme(s): Alkaline phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598913_15605365_15605366_15609731_15609732_15610086:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7470e7d1ff7fc2ee2a2a16d76c0028e3 |
| ToxValDB ECOTOX | NOEL | =750 | mg/L | Rat | oral | chronic; 132 days | chronic | LONG_REF=EPA/OTS Doc. #FYI-AX-1082-0212:22 p. Indus Acrylate Testing Group Acrylate Toxicity Data with Cover Letter & EPA Acknowledgement of Receipt of Data 1982; TITLE=Acrylate Toxicity Data with Cover Letter & EPA Acknowledgement of Receipt of Data; AUTHOR=Indus Acrylate Testing Group; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151632; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Reproduction: Reproduction, general; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15602241:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e04d579f46d359a147f233be45f1c78 |
| ToxValDB ECOTOX | NOEL | =1000 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=EPA/OTS Doc. #FYI-OTS-0787-0367:26 p. Rohm and Haas Co. Letter from Rohm Haas Co to USEPA Regarding Cytogeneticity Studies of Acrylic Acid in Chinese Hamster Ovary and Rat Bone Marrow In Vitro 1986; TITLE=Letter from Rohm Haas Co to USEPA Regarding Cytogeneticity Studies of Acrylic Acid in Chinese Hamster Ovary and Rat Bone Marrow In Vitro; AUTHOR=Rohm and Haas Co.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=151778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596497:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3ae7095979a02e09d2af8ef8e700c8fc |
| ToxValDB ECOTOX | NOEL | =2000 | mg/L | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=Food Chem. Toxicol.31(1): 1-18 Hellwig,J., K. Deckardt, and K.O. Freisberg Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats 1993; TITLE=Subchronic and Chronic Studies of the Effects of Oral Administration of Acrylic Acid to Rats; AUTHOR=Hellwig,J., K. Deckardt, and K.O. Freisberg; DOI=10.1016/0278-6915(93)90172-u; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151679; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Cell(s): Red blood cell; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598016_15598017:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=20cc54a1473ae97fe821fb6e576c39e2 |
| ToxValDB ECOTOX | NOEL | =5000 | mg/L | Rat | oral | short-term; 5 days | short-term | LONG_REF=EPA/OTS Doc. #FYI-OTS-0787-0367:26 p. Rohm and Haas Co. Letter from Rohm Haas Co to USEPA Regarding Cytogeneticity Studies of Acrylic Acid in Chinese Hamster Ovary and Rat Bone Marrow In Vitro 1986; TITLE=Letter from Rohm Haas Co to USEPA Regarding Cytogeneticity Studies of Acrylic Acid in Chinese Hamster Ovary and Rat Bone Marrow In Vitro; AUTHOR=Rohm and Haas Co.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151778; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15597936:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=12c8be675bc33ef05d322912e56174a3 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | NOAEL | =73.6844 | mg/m3 | Rat | inhalation | subchronic; 90 days | subchronic | LONG_REF=Miller RR, Ayres JA, Jersey GC, McKenna MJ (1981). Inhalation toxicity of acrylic acid. Fundam Appl Toxicol 1:271-277.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985b9e4b02565fc7d359b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/097_acrylic_acid_oel_en.pdf; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=effects on the olfactory epithelium; STUDY_GROUP=EU SCOEL:15952315:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_07c5317a9a913b923952621b3869ef37 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =30 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629498_15629499:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d84f89dbdd5aed4aa67e2c78aac35c2e |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =40 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=BASF AG, Abteilung Toxikologie (1987): Unpublished Report 821380, 11.12.1987Hellwlg, J. et ai. (1993): Fd. Chem. Toxicol. 31, 1-18Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Aug. 22, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=63698; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15640291:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a896dd224f07dc005983d6973760531 |
| ToxValDB HPVIS | NOAEL | =66 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=BASF AG, Abteilung Toxikologie (1987): Unpublished Report 821380, 11.12.1987Hellwlg, J. et ai. (1993): Fd. Chem. Toxicol. 31, 1-18Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Aug. 22, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=61363; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15640243:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dda5a8e91f9df661cc980c9c58b4f6ba |
| ToxValDB HPVIS | NOAEL | =73.6844 | mg/m3 | Rabbit | inhalation | short-term; 13 days | reproduction developmental | LONG_REF=Neeper-Bradley, T.L., Fowler, E.H., Pritts, I.M., Tyler, T.R. (1997): Food Chem. Toxicol. 35, 869-880Union Carbide, Bushy Run Research Center (1993): Unpublishedreport (Project-No.: 92N1008), 24.06.1993Posting dates of the documents from the HPV Challenge Program website from which data have been entered into the HPVIS: Aug. 22, 2006.; QUALITY=1; EXTERNAL_SOURCE_ID=58042; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS:15642326:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_04b7246c64a9d47d3ff8225e9c6d7614 |
ToxValDB IRIS 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | LOAEL | =14.94 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna. 1981a. Inhalation toxicity of acrylic acid. Fund. Appl. Toxicol. 1(3): 271-277.; TITLE=Inhalation toxicity of acrylic acid; AUTHOR=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=degeneration of the nasal olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644231_15644232_15644233:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8c955e520b64883673017ef1a432d4c1 |
| ToxValDB IRIS | LOAEL | =240 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=BASF (Badische Anilin- und Sodafabrik). 1993. Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation). Project No. 71R0114/92011. BASF Aktiengesellschaft, Dept. of Toxicology, Rhein, FRG.; TITLE=Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation); AUTHOR=BASF (Badische Anilin- und Sodafabrik); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=reduced pup weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS_dup_IRIS Summary_15644228_15644229:M/F:F1-; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_98d4a25ed4096ef1be85ec62c02fd474 |
| ToxValDB IRIS | LOAEL (ADJ) | =2.67 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna. 1981a. Inhalation toxicity of acrylic acid. Fund. Appl. Toxicol. 1(3): 271-277.; TITLE=Inhalation toxicity of acrylic acid; AUTHOR=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=degeneration of the nasal olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644231_15644232_15644233:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1d8aba2ad90ee13fac2a2ef4eb86cf8e |
| ToxValDB IRIS | LOAEL (HEC) | =0.33 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna. 1981a. Inhalation toxicity of acrylic acid. Fund. Appl. Toxicol. 1(3): 271-277.; TITLE=Inhalation toxicity of acrylic acid; AUTHOR=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=degeneration of the nasal olfactory epithelium; STUDY_GROUP=IRIS_dup_IRIS Summary_15644231_15644232_15644233:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b53f1e8cc6fbdee553942e9509b6546 |
| ToxValDB IRIS | NOAEL | =53 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=BASF (Badische Anilin- und Sodafabrik). 1993. Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation). Project No. 71R0114/92011. BASF Aktiengesellschaft, Dept. of Toxicology, Rhein, FRG.; TITLE=Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation); AUTHOR=BASF (Badische Anilin- und Sodafabrik); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=reduced pup weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=IRIS_dup_IRIS Summary_15644228_15644229:M/F:F1-; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e4529ff04ab1ce043a55c1e88f29fe35 |
| ToxValDB IRIS | RfC | =0.001 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna. 1981a. Inhalation toxicity of acrylic acid. Fund. Appl. Toxicol. 1(3): 271-277.; TITLE=Inhalation toxicity of acrylic acid; AUTHOR=Miller, R.R., J.A. Ayres, G.C. Jersey, and M.J. McKenna; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=Degeneration of the nasal olfactory epithelium in male/female mice; STUDY_GROUP=IRIS:15644234:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_30a2bfb0ffab25d640ad7f507a0d8f20 |
| ToxValDB IRIS | RfD | =0.5 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=BASF (Badische Anilin- und Sodafabrik). 1993. Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation). Project No. 71R0114/92011. BASF Aktiengesellschaft, Dept. of Toxicology, Rhein, FRG.; TITLE=Reproduction toxicity study with acrylic acid in rats: Continuous administration in the drinking water over 2 generations (1 litter in the first and 1 litter in the second generation); AUTHOR=BASF (Badische Anilin- und Sodafabrik); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a2ce4b045b9ff7a4c9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=2; TOXICOLOGICAL_EFFECT=Reduced pup weight in F1 male/female rats; STUDY_GROUP=IRIS:15644230:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_46a4f80542ae62ab3403dde4229fe46b |
ToxValDB PPRTV (CPHEA) 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | BMCL (10 HEC) | =0.02 | mg/m3 | Mouse | inhalation | subchronic; 13 weeks | subchronic | LONG_REF=Miller et al. 1981; AUTHOR=Miller et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b31e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1556; TOXICOLOGICAL_EFFECT=increased incidence of focal degeneration of the nasal olfactory epithelium; STUDY_GROUP=PPRTV (CPHEA):15653365:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_36e146ddccfa5d268eaf9798c50e8a2f |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.0002 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Miller et al. 1981; AUTHOR=Miller et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b31e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1556; TOXICOLOGICAL_EFFECT=Increase incidence of focal degeneration of the nasal olfactory epithelium in male/female mice; STUDY_GROUP=PPRTV (CPHEA):15653364:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0444701204284853c78d1d2e3d8899ea |
| ToxValDB PPRTV (CPHEA) | RfD (provisional) | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=Hellwig et al. 1997; AUTHOR=Hellwig et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b31e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1556; TOXICOLOGICAL_EFFECT=Pup toxicity in male/female rats; STUDY_GROUP=PPRTV (CPHEA):15653660:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2b503e1ff0caed8834dfd379e43d5807 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | J94PBK7X8S | UNII | - | - | - | chemical | - |