Is ACRYLIC ACID safe in cosmetics?
ACRYLIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. 4 toxicological study endpoint(s) are available in our database.
ACRYLIC ACID
Also known as: 2-Propenoic acid, Acroleic acid, LX 300 (crosslinking agent), 4-02-00-01455, Acrylic acid, glacial (+8 more)
ACRYLIC ACID (CAS 79-10-7) is a cosmetic cosmetic ingredient functioning as Nail Conditioning. NOAEL 40 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 79-10-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
ACRYLIC ACID is classified GHS Danger (H226, H302, H312, H332, H314, H318, H335, H400) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Nail Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
prop-2-enoic acid
InChIKey
NIXOWILDQLNWCW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for ACRYLIC ACID.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for ACRYLIC ACID. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =140 mg/kg bw/day | inhalation | Rat; Mouse | Chronic toxicity | INCHEM_WHO_ehc_ehc_ehc191 |
| NOAEL | =140 mg/kg bw | - | Rat | Toxicology study | INCHEM_WHO_ehc_ehc_ehc191 |
| NOAEL | =240 mg/kg bw/day | - | - | Reproductive toxicity | INCHEM_WHO_ehc_ehc_ehc191 |
| NOAEL | =331 mg/kg bw/day | - | - | Reproductive toxicity | INCHEM_WHO_ehc_ehc_ehc191 |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
FlamFlameCorrSkullToxic
Hazard Statements
Flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is corrosive to the eyes and skin. Corrosive on ingestion. The vapour is severely irritating to the eyes and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the upper respiratory tract and lungs. This may result in reduced lung function and hyperreactivity of the airways. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for ACRYLIC ACID across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
19, Sup 7, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosiveEnvironmental Hazard
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A; Aquatic Acute 1
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
- H400 Very toxic to aquatic life
Specific Concentration Limits / M-factors
STOT SE 3; H335: C ≥ 1.0%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000,000 - 10,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Acrylic acid | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 19: (1979) Some Monomers, Plastics and Synthetic Elastomers, and Acrolein | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen P
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of acrylic acid were available. No experimental data relevant to the carcinogenicity of acrylic acid were available. Overall evaluation: Acrylic acid is not classifiable as to its carcinogenicity in humans (Group 3). | A4; Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0688
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Acrylic acid reportedly is an irritant of the upper respiratory tract, eyes, skin, and gastointestinal tract in occupational settings. | Irritating to skin, eye, and respiratory system.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Flux agent
Fragrance
Monomers
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for ACRYLIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ACRYLIC ACID by CAS number or substance name.
Studies
31
Lowest NOAEL
2.4
Highest NOAEL
460
Units vary across source rows: mg/kg bw/day, mg/kg bw
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
INCHEM_WHO_ehc_ehc_ehc191
Known Synonyms
2-Propenoic acid
Acroleic acid
LX 300 (crosslinking agent)
4-02-00-01455
Acrylic acid, glacial
BRN 0635743
Caswell No. 009A
EINECS 201-177-9
Propene acid
RCRA waste number U008
Acido acrilio
Kyselina akrylova
UNII-J94PBK7X8S
Chemical Function
Softener and conditioner
Binder
Monomers
Flux agent
Fragrance
Regulatory Lists
detected; Europe; Personal care - nails - nail polish
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
CEDI
Indirect additives food contact (10/2018)
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Canada; pharmaceutical
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ACRYLIC ACID
ChEMBL ID
CHEMBL1213529
Frequently Asked Questions
Is ACRYLIC ACID allowed in the EU?
ACRYLIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ACRYLIC ACID do in cosmetics?
ACRYLIC ACID functions as: Nail Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 79-10-7.
What is the NOAEL for ACRYLIC ACID?
The NOAEL (No Observed Adverse Effect Level) for ACRYLIC ACID is =140 mg/kg bw/day based on a Chronic toxicity study via inhalation route in Rat; Mouse. A total of 4 study endpoints are available. Source: INCHEM_WHO_ehc_ehc_ehc191.
Is ACRYLIC ACID classified as hazardous under GHS?
ACRYLIC ACID carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is ACRYLIC ACID used outside cosmetics?
ACRYLIC ACID also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ACRYLIC ACID have different safety status in cosmetics vs industrial chemicals?
ACRYLIC ACID is classified GHS Danger (H226, H302, H312, H332, H314, H318, H335, H400) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check ACRYLIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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