Good Cosmetic Ingredient NOAEL Data GHS Classified

ACRYLIC ACID

CAS Number

79-10-7

Function

Nail Conditioning

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

NOAEL: 53 mg/kg bw/day (oral NOAEL used by US EPA to derive RfD) | Source: RIVM Letter report 601782023 (Environmental risk limits for acrylic acid), citing US EPA non‑canc...

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for ACRYLIC ACID. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
LOAEL	150 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	40 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	0.23 mg/L air	1995	rat	inhalation	REACH
NOAEL	83 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	410 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	0.23 mg/L air	1995	mouse	inhalation	REACH
NOAEL	0.025 other	oral	rabbit	oral	REACH
NOAEL	>=600 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	2.29 other	oral	rat	oral	REACH
NOAEL	0.77 other	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

flam;flame; corr; skull;toxic

Hazard Statements

Flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life

Short-term Exposure Effects

The substance is corrosive to the eyes and skin. Corrosive on ingestion. The vapour is severely irritating to the eyes and respiratory tract.

Long-term Exposure Effects

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the upper respiratory tract and lungs. This may result in reduced lung function and hyperreactivity of the airways. See Notes.

Routes of Exposure

The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

ACRYLIC ACID is listed in the EU CosIng database with functions: Nail Conditioning It is permitted in the EU without specific restrictions.

⚠️

Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment

Frequently Asked Questions

Is ACRYLIC ACID safe in cosmetics?

ACRYLIC ACID is listed in the EU CosIng database with functions: Nail Conditioning It is permitted in the EU without specific restrictions. The EU classifies ACRYLIC ACID as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.

Is ACRYLIC ACID allowed in the EU?

ACRYLIC ACID EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does ACRYLIC ACID do in cosmetics?

ACRYLIC ACID functions as: Nail Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 79-10-7.

What is the Margin of Safety for ACRYLIC ACID?

NOAEL: 53 mg/kg bw/day (oral NOAEL used by US EPA to derive RfD) | Source: RIVM Letter report 601782023 (Environmental risk limits for acrylic acid), citing US EPA non‑canc... The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for ACRYLIC ACID?

The NOAEL (No Observed Adverse Effect Level) for ACRYLIC ACID is 150 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Is ACRYLIC ACID classified as hazardous under GHS?

ACRYLIC ACID carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Toxic if swallowed, in contact with skin or if inhaled Causes severe skin burns and eye damage May cause respiratory irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check ACRYLIC ACID compliance across multiple jurisdictions:

🔬

Ingredient Decoder

Paste a full ingredient list for instant analysis

🌸

82 Allergen Checker

Check for EU declarable fragrance allergens

🧪

Substance Compliance

Check compliance across 55 jurisdictions

🧮

MoS Calculator

Calculate Margin of Safety using SCCS methodology

⚗️

Heavy Metal Limits

Compare limits across jurisdictions

Related Ingredients

POLYURETHANE-96

Good

BIS(METHACRYLOYLOXYETHYL) PHOSPHATE

Good

POLYURETHANE-97

Good

PEG-22 DIMETHACRYLATE

Good

PALMITOYL SH-OLIGOPEPTIDE-79

Good

Browse all 30,000+ ingredients →

📱

Is ACRYLIC ACID in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for ACRYLIC ACID in your formulation.

Ingredient Decoder MoS Calculator