Is ACRYLOYLOXY PROPYLTRIMETHOXYLANE safe in cosmetics?
ACRYLOYLOXY PROPYLTRIMETHOXYLANE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
ACRYLOYLOXY PROPYLTRIMETHOXYLANE
Also known as: 3-(Trimethoxysilyl)propyl 2-propenoate
ACRYLOYLOXY PROPYLTRIMETHOXYLANE (CAS 4369-14-6) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =40 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 4369-14-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
ACRYLOYLOXY PROPYLTRIMETHOXYLANE is classified GHS Danger (H314, H317, H318, H332, H412, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
3-trimethoxysilylpropyl prop-2-enoate
InChIKey
KBQVDAIIQCXKPI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for ACRYLOYLOXY PROPYLTRIMETHOXYLANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =40 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1; Aquatic Chronic 3
Hazard Statements
- H332 Harmful if inhaled
- H314 Causes severe skin burns and eye damage
- H317 May cause an allergic skin reaction
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: ATP01
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Chemical reaction regulator
Solvent
Wetting agent (non-aqueous)
Expert Verdict
Expert safety assessment and concern-level summary for ACRYLOYLOXY PROPYLTRIMETHOXYLANE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to ACRYLOYLOXY PROPYLTRIMETHOXYLANE by CAS number or substance name.
Studies
1
Lowest NOAEL
40 mg/kg bw/day
Highest NOAEL
40 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
3-(Trimethoxysilyl)propyl 2-propenoate
Chemical Function
Solvent
Chemical reaction regulator
Adhesion/cohesion promoter
Frequently Asked Questions
Is ACRYLOYLOXY PROPYLTRIMETHOXYLANE allowed in the EU?
ACRYLOYLOXY PROPYLTRIMETHOXYLANE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ACRYLOYLOXY PROPYLTRIMETHOXYLANE do in cosmetics?
ACRYLOYLOXY PROPYLTRIMETHOXYLANE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 4369-14-6.
What is the NOAEL for ACRYLOYLOXY PROPYLTRIMETHOXYLANE?
The NOAEL (No Observed Adverse Effect Level) for ACRYLOYLOXY PROPYLTRIMETHOXYLANE is =40 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is ACRYLOYLOXY PROPYLTRIMETHOXYLANE used outside cosmetics?
ACRYLOYLOXY PROPYLTRIMETHOXYLANE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does ACRYLOYLOXY PROPYLTRIMETHOXYLANE have different safety status in cosmetics vs industrial chemicals?
ACRYLOYLOXY PROPYLTRIMETHOXYLANE is classified GHS Danger (H314, H317, H318, H332, H412, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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MoS Calculator
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