NOAEL Studies Cosmetic Ingredient

Algin NOAEL Studies

INCI: ALGIN

CAS: 9005-38-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

Back to parent ingredient page
COSMOS_DB 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 7500 mg/kg bw/day mouse oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2000 mg/kg bw/day guinea pig oral 182 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day cat oral 98 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 11250 mg/kg bw/day dog oral 365 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 37500 mg/kg bw/day mouse oral 623 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =1.8 mg/kg bw/day Rat oral: feed 90 days subchronic EFSA NDA - 2017 - OutputID 2953 - clinical chemistry - hepatotoxicity - Safety of alginate-konjac-xanthan polysaccharide complex (PGX) as a novel food pursuant to Regulation (EC) No 258/97 - doi:10.2903/j.efsa.2017.4776
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >5000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11365; row=1349; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium alginate; preferred_name=Sodium alginate; dtxsid=DTXSID0040410; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040410; source_file=acute_oral.xlsx
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier C269C4G2ZQ UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"C269C4G2ZQ"}
openFDA substances FDA UNII substance identifier C269C4G2ZQ UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"C269C4G2ZQ"}
openFDA substances FDA UNII substance identifier C269C4G2ZQ UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"C269C4G2ZQ"}
openFDA substances FDA UNII substance identifier C269C4G2ZQ UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"C269C4G2ZQ"}