NOAEL Studies Active Ingredient

Alpha-Arbutin NOAEL Studies

INCI: ALPHA-ARBUTIN

CAS: 84380-01-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 22 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1550 - rat oral 28-day repeated dose toxicity p.37
SCCS Opinion NOAEL =1000 mg/kg bw/day rat oral 28-day repeated dose toxicity p.37
SCCS Opinion NOAEL =100 mg/kg bw/day - dermal - NOAEL study p.42
SCCS Opinion NOAEL =20 mg/kg bw/d - - - repeated dose toxicity p.43
SCCS Opinion NOAEL =15 mg/kg bw/d - - - repeated dose toxicity p.43
SCCS Opinion NOAEL =2 % - - - NOAEL study p.38
SCCS Opinion NOAEL =3.3 - guinea pig oral Sub-chronic repeated dose toxicity p.29
SCCS Opinion NOAEL =9 - - - - NOAEL study p.38
SCCS Opinion NOAEL =15 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =15 mg/kg bw - oral - carcinogenicity p.41
SCCS Opinion NOAEL =20 mg/kg/day rat oral 28d NOAEL study p.37
SCCS Opinion NOAEL =20 mg/kg bw/day - dermal - NOAEL study p.40
SCCS Opinion NOAEL =20 mg/kg bw - oral - carcinogenicity p.41
SCCS Opinion NOAEL =20 % guinea pig dermal 14-day irritation p.43
SCCS Opinion NOAEL =25 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =29 - - oral 14 days repeated dose toxicity p.29
SCCS Opinion NOAEL =56 - - dermal 14-day repeated dose toxicity p.40
SCCS Opinion NOAEL =74 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =75 mg/kg/day rat oral 28d reproductive toxicity p.38
SCCS Opinion NOAEL =150 mg/kg/day rat - - reproductive toxicity p.38
SCCS Opinion NOAEL >250 mg/kg bw rat oral 14-day repeated dose toxicity p.42
SCCS Opinion NOAEL =344 - rat - - NOAEL study p.38
Regulatory source 28 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 100 mg/kg bw/day - dermal - - p.42
Regulatory source - 2 % - - - - p.38
Regulatory source - 9 - - - - - p.38
Regulatory source - =15 mg/kg/day rat - - - p.38
Regulatory source - =20 mg/kg/day rat oral 28d - p.37
Regulatory source - 20 mg/kg bw/day - dermal - - p.40
Regulatory source - =74 mg/kg/day rat dermal 28d - p.38
Regulatory source - 344 - rat - - - p.38
Regulatory source carcinogenicity 15 mg/kg bw - oral - carcinogenicity p.41
Regulatory source carcinogenicity 20 mg/kg bw - oral - carcinogenicity p.41
Regulatory source carcinogenicity 25 mg/kg/day - - - carcinogenicity p.38
Regulatory source developmental toxicity =25 mg/kg/day rabbit - developmental developmental toxicity p.38
Regulatory source developmental toxicity =75 mg/kg/day rabbit - developmental developmental toxicity p.38
Regulatory source irritation 20 % guinea pig dermal 14-day irritation p.43
Regulatory source repeated dose toxicity 1550 - rat oral 28-day repeated dose toxicity p.37
Regulatory source repeated dose toxicity 1000 mg/kg bw/day rat oral 28-day repeated dose toxicity p.37
Regulatory source repeated dose toxicity 20 mg/kg bw/d - - - repeated dose toxicity p.43
Regulatory source repeated dose toxicity 15 mg/kg bw/d - - - repeated dose toxicity p.43
Regulatory source repeated dose toxicity 3.3 - guinea pig oral Sub-chronic repeated dose toxicity p.29
Regulatory source repeated dose toxicity 29 - - oral 14 days repeated dose toxicity p.29
Regulatory source repeated dose toxicity 56 - - dermal 14-day repeated dose toxicity p.40
Regulatory source repeated dose toxicity >250 mg/kg bw rat oral 14-day repeated dose toxicity p.42
Regulatory source repeated dose toxicity >250 mg/kg bw guinea pig oral 14-day repeated dose toxicity p.42
Regulatory source reproductive toxicity =15 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =25 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =74 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =75 mg/kg/day rat oral 28d reproductive toxicity p.38
Regulatory source reproductive toxicity =150 mg/kg/day rat - - reproductive toxicity p.38
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 72VUP07IT5 UNII - - - chemical -