Good Cosmetic Ingredient NOAEL Data GHS Classified

Alumina

INCI: ALUMINA

CAS Number
1344-28-1
Function
Abrasive, Absorbent, Anticaking, Bulking, Opacifying, Viscosity Controlling
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR concluded safe in the present practices of use and concentration (2016). FDA-approved as indirect food additive and used in medical device implants.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Alumina. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=10 other oral rat oral REACH
NOAEL >=4176.5 mg/kg bw/day oral mouse oral REACH
NOAEL >=1000 mg/kg bw/day oral rat oral REACH
LOAEL 33352.94 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
Inhalation of high concentrations of dust may cause irritation of the eyes and respiratory tract.
Long-term Exposure Effects
The substance may have effects on the central nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.

Expert Verdict

Inhalation concern in powdered and sprayable forms; aggregated aluminum exposure from cosmetics and diet may exceed safe limits at highest exposure ranges.

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Concern Level: Moderate

Frequently Asked Questions

Is Alumina safe in cosmetics?

Inhalation concern in powdered and sprayable forms; aggregated aluminum exposure from cosmetics and diet may exceed safe limits at highest exposure ranges. The EU classifies Alumina as "permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is Alumina allowed in the EU?

Alumina EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Alumina do in cosmetics?

Alumina functions as: Abrasive, Absorbent, Anticaking, Bulking, Opacifying, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 1344-28-1.

What is the Margin of Safety for Alumina?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Alumina?

The NOAEL (No Observed Adverse Effect Level) for Alumina is >=10 other based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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