NOAEL Studies
Cosmetic Ingredient
Aluminum Chloride NOAEL Studies
INCI: ALUMINUM CHLORIDE
CAS: 7446-70-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE skin irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | Breakthrough Time | 16.5 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=4255; Record_ID=skin_irritation_invitro_1; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6029674; Assay=Corrositex; Endpoint=Breakthrough Time; Response=16.5; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029674 |
NTP ICE skin sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9933; Record_ID=skin_sensitization_invivo_2200; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6029674; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029674 |
| NTP ICE skin sensitization | Induction dose per skin area | 12410 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9931; Record_ID=skin_sensitization_invivo_2200; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6029674; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=12410; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029674 |
| NTP ICE skin sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9961; Record_ID=skin_sensitization_invivo_2206; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6029674; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Magnusson and Kligman 1969; 5774356; 10.1038/jid.1969.42|Basketter et al. 1999; 10654593; 10.1016/S0278-6915(99)00112-x|Basketter et al. 2014; 24407057; 10.1097/der.0000000000000003; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029674 |
| NTP ICE skin sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=9937; Record_ID=skin_sensitization_invivo_2200; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6029674; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6029674 |
ToxValDB DOE Wildlife Benchmarks 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =19.3 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511525_15511526:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb874a83cc883b46f3547d1d2ffb358e |
| ToxValDB DOE Wildlife Benchmarks | LOAEL | =44.5 | mg/kg bw/day | Chicken | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks:15511528:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d701d197eae155b8dad13aa35039c6a |
| ToxValDB DOE Wildlife Benchmarks | NOAEL | =1.93 | mg/kg bw/day | Mouse | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511525_15511526:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b92294cdca5c0d010a1bdf0b6c31096f |
ECHA 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | =0.1 | mg/m3 | Rat | inhalation | acute; 6 hours | acute | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15901/7/6/3?documentUUID=72ce0e98-4784-472a-aa0c-a0886f6bb245; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15827969:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6039f56d3420c6ae0ffaaf3fc06c8d9e |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac62e4b0a7c65d1beda1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15901/7/9/3?documentUUID=72ce0e98-4784-472a-aa0c-a0886f6bb245; YEAR=1996; ORIGINAL_YEAR=1996; STUDY_GROUP=ECHA IUCLID:15820780:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b555f01d79921d53d8795375aab879e |
ToxValDB ECOTOX 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =1000 | ppm | Rat | oral | short-term; 14 days | reproduction developmental | LONG_REF=Proc. Soc. Exp. Biol. Med.161(1): 74-77 McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat 1979; TITLE=Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat; AUTHOR=McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook; DOI=10.3181/00379727-161-40493; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594689_15594690:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2f9bb19159a6222f04c8a40e3d0c8985 |
| ToxValDB ECOTOX | LOEL | =1000 | mg/L | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=Hum. Exp. Toxicol.17(10): 570-576 Bataineh,H., M.H. Al-Hamood, and A.M. Elbetieha Assessment of Aggression, Sexual Behavior and Fertility in Adult Male Rat Following Long-Term Ingestion of Four Industrial Metals Salts 1998; TITLE=Assessment of Aggression, Sexual Behavior and Fertility in Adult Male Rat Following Long-Term Ingestion of Four Industrial Metals Salts; AUTHOR=Bataineh,H., M.H. Al-Hamood, and A.M. Elbetieha; DOI=10.1177/096032719801701008; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=58230; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Behavior: Aggression|Behavior: Displaying behavior|Growth: Weight|Morphology: Weight|Reproduction: Mounting, copulation, intercourse; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|neurobehavior|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595666_15597599:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=85beb8f85545d2b90238db0e72cf700a |
| ToxValDB ECOTOX | NOEL | =500 | ppm | Rat | oral | short-term; 14 days | reproduction developmental | LONG_REF=Proc. Soc. Exp. Biol. Med.161(1): 74-77 McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat 1979; TITLE=Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat; AUTHOR=McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook; DOI=10.3181/00379727-161-40493; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594689_15594690:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=16e050abbf21344f3b74aa84917709e2 |
| ToxValDB ECOTOX | NOEL | =1000 | ppm | Rat | oral | short-term; 14 days | developmental | LONG_REF=Proc. Soc. Exp. Biol. Med.161(1): 74-77 McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat 1979; TITLE=Effect of Prenatal Administration of Aluminum and Parathyroid Hormone on Fetal Development in the Rat; AUTHOR=McCormack,K.M., L.D. Ottosen, V.L. Sanger, S. Sprague, G.H. Mayor, and J.B. Hook; DOI=10.3181/00379727-161-40493; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79487; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Development: Abnormal|Development: Deformation|Development: Weight|Growth: Length|Morphology: Absence, absent|Morphology: Size|Morphology: Supernumerary ribs|Mortality: Mortality|Reproduction: Resorbed embryos; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other|reproduction; STUDY_GROUP=ECOTOX:15595557:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6b4849d4da9b0c7005b2c0d3bb2fcab2 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | LIF1N9568Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Al.3Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LIF1N9568Y"} |
| openFDA substances | FDA UNII substance identifier | LIF1N9568Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Al.3Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LIF1N9568Y"} |
| openFDA substances | FDA UNII substance identifier | LIF1N9568Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Al.3Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LIF1N9568Y"} |
| openFDA substances | FDA UNII substance identifier | LIF1N9568Y | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"Al.3Cl","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"LIF1N9568Y"} |