Is Aluminum Chloride safe in cosmetics?
Aluminum Chloride has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Aluminum Chloride
Also known as: AlCl3, aluminium chloride, [AlCl3], Aluminum chloride (AlCl3), Aluminum chloride (1:3) (+10 more)
INCI: ALUMINUM CHLORIDE
Aluminum Chloride (CAS 7446-70-0) is a cosmetic cosmetic ingredient functioning as Antiperspirant, Astringent, Deodorant. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 6.18%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7446-70-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aluminum Chloride is classified GHS Danger (H290, H314, H318, H315, H319, H302, H341, H361) in the chemicals database but is allowed in EU cosmetics at max 6.18%.
Source: Cosmetics: ingredients.eu status/eu max; Chemicals: ghs classifications.signal word/hazard statement code
Function
Antiperspirant, Astringent, Deodorant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
trichloroalumane
InChIKey
VSCWAEJMTAWNJL-UHFFFAOYSA-K
Regulatory Status
EU EU Status
permitted
EU Max Conc.
6.18%
US US Status
permitted
US Notes
Permitted as OTC antiperspirant active under FDA Monograph (21 CFR 350); max 15% anhydrous in aerosol, 25% in other dosage forms
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aluminum Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Aluminum Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =100 mg/kg bw/day | oral | Rat | developmental | ECHA |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Aluminum Chloride across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Skin Corr. 1B
Hazard Statements
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 12413.79 | - | - |
| HMT | - | 0 | 15517.24 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: heavy metal
Receptor targets: ERα
LOEC: 100 µM
EU status: allowed (max 20% in antiperspirants)
metalloestrogen; agonist (ERα)
Dose-Response Data Points
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| LOAEL_puberty | reproductive | 50–500 mg/kg/day | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
deodorant
{"cas_number": "7446-70-0", "ingredient_class": "antiperspirant_active", "mechanism_of_action": "sweat_gland_blocking", "antiperspirant_efficacy_sweat_reduction_pct": "50-85", "deodorant_efficacy_hours": "48-72", "odor_reduction_pct": "80-95", "bacteriostatic": "yes", "bactericidal": "yes", "target_bacteria": "broad_spectrum", "microbiome_impact": "broad", "axillary_microbiome_effect": "significan…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Not listed by IARC. IARC classified aluminum production as carcinogenic to humans (Group 1), but did not implicate aluminum itself as a human carcinogen. (L135) A link between use of aluminum-containing antiperspirants and increased risk of breast cancer has been proposed (A235), but studies have not been able to establish a clear link (A15468).
Source: Toxin and Toxin Target Database (T3DB)
Evidence for Carcinogenicity
A4: Not classifiable as a human carcinogen. /Aluminum metal and insouble compound/
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1125
Source: WHO/JECFA
Skin Eye Respiratory Irritation
Irritating to eyes, nose and throat. Will burn skin and eyes. | May cause minor irritation to lungs & eyes. /Aluminum (dust or powder)/ | Irritation of the eyes has been noted in patients who have been exposed /to aluminum alkyls/. /Aluminum alkyls/ | May cause minor irritation to lungs or eyes. /Aluminum (dust or powder)/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antiperspirant
Astringent
Deodorizer
Expert Verdict
Expert safety assessment and concern-level summary for Aluminum Chloride.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Aluminum Chloride by CAS number or substance name.
Studies
1
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
100 mg/kg bw/day
ECHA
Known Synonyms
AlCl3
aluminium chloride
[AlCl3]
Aluminum chloride (AlCl3)
Aluminum chloride (1:3)
Caswell No. 029
EINECS 231-208-1
EPA Pesticide Chemical Code 013901
Pearsall
Alluminio(cloruro di)
Aluminium, (chlorure d')
Aluminum, (chlorure d')
UNII-LIF1N9568Y
Hemoban
Aluminum chloride anhydrous
Chemical Function
Astringent
Deodorizer
Antiperspirant
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
fracking; water
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALUMINUM CHLORIDE ANHYDROUS
ChEMBL ID
CHEMBL3833401
Max Phase
1
Frequently Asked Questions
Is Aluminum Chloride allowed in the EU?
Aluminum Chloride EU regulatory status: permitted. Maximum allowed concentration: 6.18%. This is based on EU Regulation 1223/2009 and its amendments.
What does Aluminum Chloride do in cosmetics?
Aluminum Chloride functions as: Antiperspirant, Astringent, Deodorant. It is classified as a cosmetic ingredient in our database. CAS number: 7446-70-0.
What is the NOAEL for Aluminum Chloride?
The NOAEL (No Observed Adverse Effect Level) for Aluminum Chloride is =100 mg/kg bw/day based on a developmental study via oral route in Rat. Source: ECHA.
Is Aluminum Chloride used outside cosmetics?
Aluminum Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aluminum Chloride have different safety status in cosmetics vs industrial chemicals?
Aluminum Chloride is classified GHS Danger (H290, H314, H318, H315, H319, H302, H341, H361) in the chemicals database but is allowed in EU cosmetics at max 6.18%.
Compliance Tools
Check Aluminum Chloride compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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