NOAEL Studies
Cosmetic Ingredient
Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate NOAEL Studies
INCI: ALUMINUM HYDROXY BIS(2,2'-METHYLENE BIS(4,6-DI-T-BUTYLPHENYL))PHOSPHATE
CAS: 151841-65-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 150 | mg/kg bw/day | rat | oral | 93 day | Subchronic | FCN; A subchronic (3-month) toxicity study in the rat via oral gavage administration |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | rat | oral | 93 day | Subchronic | FCN; A subchronic (3-month) toxicity study in the rat via oral gavage administration |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | >=50 | mg/kg bw/day | Dog | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7ee4b0a7c65d1c4813; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/22825?documentUUID=7c2a6f3d-43da-4436-a478-33cf2e77b4bb; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=clinical signs|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15831480:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3609293fb230226d52ab25edf8c46677 |
| ECHA | NOEL | =50 | mg/kg bw/day | Rat | oral | - | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead7ee4b0a7c65d1c4819; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/22825?documentUUID=7c2a6f3d-43da-4436-a478-33cf2e77b4bb; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15843965:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_47d3828eccee21b700f82d9bff635927 |
| ECHA | NOEL | =80 | mg/kg bw/day | Rat | oral | - | short-term | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca9de4b0a7c65d222a3e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/22825?documentUUID=7c2a6f3d-43da-4436-a478-33cf2e77b4bb; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID:15831339:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee04f9a0bca8b86fece71d31bfbdbdb3 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =3.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632660:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66f22ca47bc49746a765ac8142e76b89 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 32S296KGN1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2C29H42O4P.Al.HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"32S296KGN1"} |
| openFDA substances | FDA UNII substance identifier | 32S296KGN1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2C29H42O4P.Al.HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"32S296KGN1"} |
| openFDA substances | FDA UNII substance identifier | 32S296KGN1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2C29H42O4P.Al.HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"32S296KGN1"} |
| openFDA substances | FDA UNII substance identifier | 32S296KGN1 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"2C29H42O4P.Al.HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"32S296KGN1"} |