Moderate Cosmetic Ingredient NOAEL Data

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate

Also known as: Aluminum, hydroxybis[2,​4,​8,​10-​tetrakis(1,​1-​dimethylethyl)​-​6-​(hydroxy-​κO)​-​12H-​dibenzo[d,​g]​[1,​3,​2]​dioxaphosphocin 6-​oxidato]​-, Aluminum, hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]-, 12H-Dibenzo[d,g][1,3,2]dioxaphosphocin, aluminum deriv., Hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-(hydroxy-κO)-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]aluminum, ADK Stab NA 21E (+10 more)

INCI: ALUMINUM HYDROXY BIS(2,2'-METHYLENE BIS(4,6-DI-T-BUTYLPHENYL))PHOSPHATE

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate (CAS 151841-65-5) is a cosmetic cosmetic ingredient functioning as Skin protectant, viscosity controlling agent, crystal growth inhibitor. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 151841-65-5 →

Auto-generated CPSR Part A draft with source citations
Function
Skin protectant, viscosity controlling agent, crystal growth inhibitor
Safety Rating
MODERATE

Chemistry & Identifiers

Formula
C58H86AlO9P2
MW
1016.2 g/mol
EC Number
430-650-4
PubChem CID
16686081
InChIKey
MUBYBLSNBCQXCW-UHFFFAOYSA-L

Regulatory Status

EU EU Status prohibited
US US Status permitted
US Notes FDA UNII: 32S296KGN1; no specific CIR safety assessment published; limited cosmetic use data

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat Subchronic COSMOS_DB

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate across SCCS product categories, with measured dermal absorption where available.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Pictograms
Environmental Hazard
Hazard Class and Category
Aquatic Chronic 2
Hazard Statements
  • H411 Toxic to aquatic life with long lasting effects

Inserted via ATP: ATP01

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
FDA Indirect Food Contact Additives

Expert Verdict

Expert safety assessment and concern-level summary for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate.

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate by CAS number or substance name.

Studies
1
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
50 mg/kg bw/day
COSMOS_DB

Known Synonyms

Aluminum, hydroxybis[2,​4,​8,​10-​tetrakis(1,​1-​dimethylethyl)​-​6-​(hydroxy-​κO)​-​12H-​dibenzo[d,​g]​[1,​3,​2]​dioxaphosphocin 6-​oxidato]​- Aluminum, hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]- 12H-Dibenzo[d,g][1,3,2]dioxaphosphocin, aluminum deriv. Hydroxybis[2,4,8,10-tetrakis(1,1-dimethylethyl)-6-(hydroxy-κO)-12H-dibenzo[d,g][1,3,2]dioxaphosphocin 6-oxidato]aluminum ADK Stab NA 21E Aluminium hydroxy bis[2,2'-methylene-bis(4,6-di-tert-butylphenyl) phosphate] Aluminum hydroxybis[2,2'-methylenebis[4,6-di(tert-butyl)phenyl]phosphate] Aluminum methylenebis(2,4-di-tert-butyl-benzyloxy)phosphate Bis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,2,3]dioxaphosphocin-6-oxide) aluminum hydroxide salt Bis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,2,3]dioxaphosphocin-6-oxide)aluminum hydroxide Bis(2,4,8,10-tetra-tert-butyl-6-hydroxy-12H-dibenzo[d,g][1,3,2]dioxaphosphocin-6-oxide) aluminum hydroxide Bis[2,2'-methylenebis(4,6-di-tert-butylphenyl) phosphate] aluminum hydroxide salt Hydroxyaluminum-bis[2,2-methylene-bis(4,6-di-tert-butylphenyl)phosphate] NA 13 (nucleating agent) ELINCS No.: 430-650-4

Chemical Function

Softener and conditioner

Regulatory Lists

CEDI Indirect additives food contact (10/2018)

Australian Status

AICIS status: listed_with_terms

Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.

Frequently Asked Questions

Is Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate safe in cosmetics?

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.

Is Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate allowed in the EU?

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate do in cosmetics?

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate functions as: Skin protectant, viscosity controlling agent, crystal growth inhibitor. It is classified as a cosmetic ingredient in our database. CAS number: 151841-65-5.

What is the NOAEL for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate?

The NOAEL (No Observed Adverse Effect Level) for Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.

Is Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate used outside cosmetics?

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate have different safety status in cosmetics vs industrial chemicals?

Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate is prohibited in EU cosmetics but has active industrial GHS classifications (H332, H411).

Is Aluminum Hydroxy Bis-Methylene Bis-Di-T-Butylphenyl Phosphate in Your Products?

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