NOAEL Studies Cosmetic Ingredient

Aminoguanidine Bicarbonate NOAEL Studies

INCI: AMINOGUANIDINE BICARBONATE

CAS: 2582-30-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =88 mg/kg bw/day Rat oral - reproduction developmental GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd236; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23157/7/9/3?documentUUID=da77e376-7e28-4c6c-a32b-d435ba208bda; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15824672:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9335b1b00a907238c23e399d06c895b1
ToxValDB_ECHA_IUCLID NOAEL =88 mg/kg bw/day Rat oral subchronic; 55 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6b4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23157/7/6/2?documentUUID=da77e376-7e28-4c6c-a32b-d435ba208bda; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15847649:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3445c9a947ef91f27bae26a92560c0c9
ToxValDB_ECHA_IUCLID NOAEL ~300 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6b4e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23157/7/6/2?documentUUID=da77e376-7e28-4c6c-a32b-d435ba208bda; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15849343:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_abe42bc2c4ed8f1f8f1c1f0e8c5db249
ToxValDB_ECHA_IUCLID NOAEL ~1000 mg/kg bw/day Rat oral subchronic; 34 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6b56; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23157/7/6/2?documentUUID=da77e376-7e28-4c6c-a32b-d435ba208bda; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846493_15849344:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b788d7efed273ae3dca259dfe411ae1d
ToxValDB_ECHA_IUCLID NOEL =300 mg/kg bw/day Rat oral subchronic; 34 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eadede4b0a7c65d1c6b56; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23157/7/6/2?documentUUID=da77e376-7e28-4c6c-a32b-d435ba208bda; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846493_15849344:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8156fe97e07616881ec8866f4d25861e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.34 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629753:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c7f1ac1804b2701b21720cf9cdff2dd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier X2151435R9 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH7N4.CHO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X2151435R9"}
openFDA substances FDA UNII substance identifier X2151435R9 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH7N4.CHO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X2151435R9"}
openFDA substances FDA UNII substance identifier X2151435R9 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH7N4.CHO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X2151435R9"}
openFDA substances FDA UNII substance identifier X2151435R9 UNII - - - chemical {"approval_status":null,"molecular_formula":"CH7N4.CHO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X2151435R9"}