Is Aminoguanidine Bicarbonate safe in cosmetics?
Aminoguanidine Bicarbonate has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Aminoguanidine Bicarbonate
Also known as: 1-Aminoguanidine bicarbonate, N1-Aminoguanidine carbonate (1:1), Aminoguanidine carbonate (1:1), Aminoguanidine hydrocarbonate, Aminoguanidine hydrogen carbonate (+8 more)
INCI: AMINOGUANIDINE BICARBONATE
Aminoguanidine Bicarbonate (CAS 2582-30-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. Reported NOAEL =88 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2582-30-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Aminoguanidine Bicarbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H360, H411).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin Conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-aminoguanidine;carbonic acid
InChIKey
OTXHZHQQWQTQMW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically prohibited by FDA but not GRAS for cosmetics; limited use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminoguanidine Bicarbonate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Aminoguanidine Bicarbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =88 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Aminoguanidine Bicarbonate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Aminoguanidine Bicarbonate by CAS number or substance name.
Studies
1
Lowest NOAEL
88 mg/kg bw/day
Highest NOAEL
88 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1-Aminoguanidine bicarbonate
N1-Aminoguanidine carbonate (1:1)
Aminoguanidine carbonate (1:1)
Aminoguanidine hydrocarbonate
Aminoguanidine hydrogen carbonate
Aminoguanidinium bicarbonate
Aminoguanidium hydrogen carbonate
BA 51-090222
EINECS 219-956-7
Guanidine, amino-, hydrogen carbonate
NSC 7887
N(sup 1)-Aminoguanidine carbonate (1:1)
UNII-X2151435R9
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Aminoguanidine Bicarbonate allowed in the EU?
Aminoguanidine Bicarbonate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminoguanidine Bicarbonate do in cosmetics?
Aminoguanidine Bicarbonate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 2582-30-1.
What is the NOAEL for Aminoguanidine Bicarbonate?
The NOAEL (No Observed Adverse Effect Level) for Aminoguanidine Bicarbonate is =88 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Aminoguanidine Bicarbonate used outside cosmetics?
Aminoguanidine Bicarbonate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aminoguanidine Bicarbonate have different safety status in cosmetics vs industrial chemicals?
Aminoguanidine Bicarbonate is prohibited in EU cosmetics but has active industrial GHS classifications (H317, H360, H411).
Compliance Tools
Check Aminoguanidine Bicarbonate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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