NOAEL Studies
Cosmetic Ingredient
Aminopropyl Triethoxysilane NOAEL Studies
INCI: AMINOPROPYL TRIETHOXYSILANE
CAS: 919-30-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP ICE acute inhalation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | >0.0452 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1523; Record_ID=acute_inhalation_783; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2027333; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.0452; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15027/7/3/3/?documentUUID=49486518-b71f-4977-8e8f-1188e571d121; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333 |
| NTP ICE acute inhalation | LC50 | >0.1448 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1524; Record_ID=acute_inhalation_782; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2027333; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.1448; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15027/7/3/3/?documentUUID=49486518-b71f-4977-8e8f-1188e571d121; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333 |
| NTP ICE acute inhalation | LC50 | >7.35 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1522; Record_ID=acute_inhalation_784; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2027333; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=7.35; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15027/7/3/3/?documentUUID=61456305-e62a-401e-bc2d-eccc6977de30; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333 |
NTP ICE acute oral 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >1340 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11428; row=4226; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1570 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11429; row=4225; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >1610 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11430; row=4228; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =1780 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11431; row=4222; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <1850 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11432; row=4227; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =2830 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11433; row=4223; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | <4980 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_11434; row=4224; data_type=In Vivo; mixture=Chemical; chemical_name=3-Aminopropyltriethoxysilane; preferred_name=3-Aminopropyltriethoxysilane; dtxsid=DTXSID2027333; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=3052; RecordID=ARPathway2016_1715; DatasetName=ARPathway2016; DTXSID=DTXSID2027333; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=785; Record_ID=eye_irritation_68; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2027333; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2027333 |
ECHA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEC | >=147000 | mg/m3 | Rat | inhalation | chronic; 19 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15027/7/6/3?documentUUID=c45555e4-9cf3-474e-bfbb-908e87066958; YEAR=1995; ORIGINAL_YEAR=1995; STUDY_GROUP=ECHA IUCLID:15827639:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_abe577ac166353b89bea3be3cc407499 |
| ECHA | LOAEL | =600 | mg/kg bw/day | Rat | oral | chronic; 92 days | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf6fe4b0a7c65d1cddab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15027?documentUUID=5b3f820c-e768-4789-ba6f-920ed480fdec; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=clinical signs|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838888_15840195_15847242_15848002:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eabfd70d6b49fb73e89e488671770a0a |
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 51 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf6fe4b0a7c65d1cddae; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15027?documentUUID=5b3f820c-e768-4789-ba6f-920ed480fdec; YEAR=2014; ORIGINAL_YEAR=2014; STUDY_GROUP=ECHA IUCLID:15848097:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eaa74cf1ecefacfcd2d171289b0a4a7b |
| ECHA | NOAEL | >=75 | mg/kg bw/day | Rat | oral | subchronic (developmental); 63 days | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf6fe4b0a7c65d1cdd97; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15027?documentUUID=5b3f820c-e768-4789-ba6f-920ed480fdec; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=behavior: functional findings; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15847495_15848174:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0aa14e84cfed4faf3369ace460e67769 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1c2e4b0a7c65d230143; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16621/7/9/3?documentUUID=4d75b335-34bc-4bdd-93fe-5aba90fdc9ad; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821724_15824629:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2a558596395c237c2d30fb1c84056879 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | chronic; 92 days | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf6fe4b0a7c65d1cddab; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/15027?documentUUID=5b3f820c-e768-4789-ba6f-920ed480fdec; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|-; TOXICOLOGICAL_EFFECT_CATEGORY=-|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838888_15840195_15847242_15848002:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_40e536c5b790fa9c3977bf5fdd11ef19 |
| ECHA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac0de4b0a7c65d1bd18a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16621/7/9/3?documentUUID=4d75b335-34bc-4bdd-93fe-5aba90fdc9ad; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821724_15824629:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f42349d1b7b34c07f81d0bad91d89b08 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =14 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629785:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e3dba61465bde29184c399c87931c8e |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | L8S6UBW552 | UNII | - | - | - | chemical | - |