Is Aminopropyl Triethoxysilane safe in cosmetics?
Aminopropyl Triethoxysilane has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Aminopropyl Triethoxysilane
Also known as: gamma-Aminopropyltriethoxy silane, 1-Propanamine, 3-(triethoxysilyl)-, 4-04-00-04273, (gamma-Aminopropyl)triethoxysilane, BRN 1754988 (+7 more)
INCI: AMINOPROPYL TRIETHOXYSILANE
Aminopropyl Triethoxysilane (CAS 919-30-2) is a cosmetic cosmetic ingredient functioning as Binding agent (surface treatment/coupling agent for pigments and powders). Reported NOAEL =50 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Aminopropyl Triethoxysilane is classified GHS Danger (H302, H314, H317, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Binding agent (surface treatment/coupling agent for pigments and powders)
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Listed in PCPC/INCI; no specific FDA restriction for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Aminopropyl Triethoxysilane.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Aminopropyl Triethoxysilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =100 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ECHA |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Harmful / IrritantCorrosive
Hazard Class and Category
Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Chemical reaction regulator
Filler
Hardener
Processing aids not otherwise specified
Surface modifier
Surfactant (surface active agent)
Thickening agent
Wetting agent (non-aqueous)
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Aminopropyl Triethoxysilane — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Aminopropyl Triethoxysilane by CAS number or substance name.
Studies
3
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
gamma-Aminopropyltriethoxy silane
1-Propanamine, 3-(triethoxysilyl)-
4-04-00-04273
(gamma-Aminopropyl)triethoxysilane
BRN 1754988
EINECS 213-048-4
Silane 1100
Silane amg-9
Silane, gamma-aminopropyltriethoxy-
Silane, (3-aminopropyl)triethoxy-
Silicone A-1100
UNII-L8S6UBW552
Chemical Function
Surfactant (surface active agent)
Hardener
Processing aids not otherwise specified
Adhesion/cohesion promoter
Chemical reaction regulator
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1542365
Frequently Asked Questions
Is Aminopropyl Triethoxysilane allowed in the EU?
Aminopropyl Triethoxysilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Aminopropyl Triethoxysilane do in cosmetics?
Aminopropyl Triethoxysilane functions as: Binding agent (surface treatment/coupling agent for pigments and powders). It is classified as a cosmetic ingredient in our database. CAS number: 919-30-2.
What is the NOAEL for Aminopropyl Triethoxysilane?
The NOAEL (No Observed Adverse Effect Level) for Aminopropyl Triethoxysilane is =50 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 3 study endpoints are available. Source: ECHA.
Is Aminopropyl Triethoxysilane used outside cosmetics?
Aminopropyl Triethoxysilane also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Aminopropyl Triethoxysilane have different safety status in cosmetics vs industrial chemicals?
Aminopropyl Triethoxysilane is classified GHS Danger (H302, H314, H317, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Aminopropyl Triethoxysilane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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