NOAEL Studies
Cosmetic Ingredient
Ammonia NOAEL Studies
INCI: AMMONIA
CAS: 7664-41-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
Regulatory source 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | LOAEL | =34.8284 | mg/m3 | Human (M/F) | inhalation | acute; 2 hours | clinical | ATSDR MRLs; row_hash=d39f96879977bbd3; source_hash=ToxValhc_4cfe6e3b8aafd25400417bd5d31cf630; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=50; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Verberk MM. 1977. Effects of ammonia in volunteers. Int Arch Occup Environ Health 39:73-81.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d |
| Regulatory source | NOAEL | =6.40842 | mg/m3 | Human (M) | inhalation | chronic; 12.2 years | occupational | ATSDR MRLs; row_hash=09c8166dfe58f347; source_hash=ToxValhc_4e142f9578b04c6d5d2c7097a05bf5bd; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=9.2; raw_unit=ppm; effect=respiratory; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Holness DL, Purdham JT, Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am Ind Hyg Assoc J 50:646-650.; stored_source_record=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d |
| Regulatory source | NOAEL (ADJ) | =4.9 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=b254ab572897ef75; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (ADJ): 4.9 mg/m^3; system=Respiratory; basis=Decreased lung function and respiratory symptoms; point_of_departure=NOAEL (ADJ): 4.9 mg/m^3; composite_uf=10; confidence=Medium; dtxsid=DTXSID0023872; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; rfc_last_updated=09/20/2016; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0422_summary.pdf |
| Regulatory source | RfC | =0.5 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=c8e2cde93b4687ff; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=5e-1; system=Respiratory; basis=Decreased lung function and respiratory symptoms; point_of_departure=NOAEL (ADJ): 4.9 mg/m^3; composite_uf=10; confidence=Medium; dtxsid=DTXSID0023872; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; rfc_last_updated=09/20/2016; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0422_summary.pdf |
CIR Safety Assessment 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =9.2 | ppm | human | inhalation | chronic | inhalation toxicity | 0; 1; 9, p.13 |
| CIR Safety Assessment | NOAEL | =250 | mg/kg/day | rat | oral | 8 weeks | inhalation toxicity | 7; 0; 01, p.7 |
| CIR Safety Assessment | NOAEL | =256 | mg/kg/day | - | oral | - | developmental toxicity | 3; 2; 0, p.8 |
| CIR Safety Assessment | NOAEL | =1500 | mg/kg/day | rat | oral | 6 weeks | developmental toxicity | 7; 35; 6, p.8 |
WHO/JECFA 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | LOAEL | =143 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=c39ab8d01e82df81; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | NOAEL | =25 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=6f70d6df57c4dccb; raw_unit=ppm; context=NEG therefore considers 5 ppm as a pragmatic NOAEL and 25 ppm as a LOAEL for irritation. |
| WHO/JECFA | NOAEL | =40 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=b9ab3057a3b7ab9a; raw_unit=mg/m3; context=A NOAEL of 40 mg/m3 (57 ppm) can be concluded from this study. |
| WHO/JECFA | NOAEL | =57 | ppm | Rat | inhalation | 2-month | Inhalation toxicity | document_id=kemi_kemi_ah2005_13; title=The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals 137. Ammonia; path=mirror/documents/kemi/kemi/ah2005_13.pdf; row_hash=04255de161eb7f53; raw_unit=ppm; context=A NOAEL of 57 ppm and a LOAEL of 143 ppm for toxic effects were reported in a 2-month inhalation exposure of white rats. |
| WHO/JECFA | LOAEL | =2 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=830266de5f9345e0; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | LOAEL | =10 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=072cabdf0505f39c; raw_unit=ppm; context=The authors concluded that 10 ppm hexanal has a weak irritating effect, and in this study it was the LOAEL (lowest observed adverse effect level) and 2 ppm was the NOAEL (no observed adverse effect level). |
| WHO/JECFA | NOAEL | =5 | ppm | - | - | - | Toxicology study | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=6ec473e8be7b3422; raw_unit=ppm; context=In this study, therefore, the NOAEL was concluded to be 5 ppm. |
| WHO/JECFA | NOAEL | =125 | mg/kg bw/day | Rat; Mouse | inhalation | 4 weeks | Inhalation toxicity | document_id=kemi_kemi_ah2006_11; title=Scientific Basis for Swedish Occupational Standards XXVII; path=mirror/documents/kemi/kemi/ah2006_11.pdf; row_hash=3c273e82a65c7443; raw_unit=mg/kg/day; context=study 2 ppm (8 mg/m3) 2 hours No clear effects 13 10 ppm (40 mg/m3) 2 hours Irritation with increased blinking frequency Rat study Hexanal in drinking water 12,6 mg/kg/day 4 weeks NOAEL for most endpoints 26 125 mg/kg/day 4 weeks Slight effects on thyroid, liver, kidneys Mouse study Inhalation 1116 ppm (4.6 g/m3) (Swiss-Webster) 1029 ppm (4.2 g/m3) (B6C3F1) 10 minutes RD50 (the concentration that reduces respiratory rate by 50%) 42 In vitro studies β-cells (rats) 0,001 mM LOAE |
NTP ICE acute inhalation 29 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 17.759 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=206; Record_ID=acute_inhalation_2057; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=17.759; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 12.1134 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=207; Record_ID=acute_inhalation_1733; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.1134; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.04 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=208; Record_ID=acute_inhalation_1731; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.04; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 18.6 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=209; Record_ID=acute_inhalation_1730; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=18.6; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 19.96 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=210; Record_ID=acute_inhalation_732; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.96; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 1.3923 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=211; Record_ID=acute_inhalation_1331; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.3923; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 9.85 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=212; Record_ID=acute_inhalation_729; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.85; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.59 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=213; Record_ID=acute_inhalation_730; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.59; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 13.77 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=214; Record_ID=acute_inhalation_728; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.77; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.939 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=215; Record_ID=acute_inhalation_724; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.939; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 28.13 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=216; Record_ID=acute_inhalation_733; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.13; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 14.17 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=217; Record_ID=acute_inhalation_731; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.17; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=a88749e0-6c4b-4bd9-ad56-63951375228d; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.5558 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=218; Record_ID=acute_inhalation_2065; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.5558; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 13.7075 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=219; Record_ID=acute_inhalation_2064; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=13.7075; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 9.8057 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=220; Record_ID=acute_inhalation_2063; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=9.8057; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 14.1315 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=221; Record_ID=acute_inhalation_2062; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.1315; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 16.515 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=222; Record_ID=acute_inhalation_2061; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=16.515; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 12.2046 | mg/L | - | Inhalation | Duration=40 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=223; Record_ID=acute_inhalation_2060; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12.2046; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 19.9059 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=224; Record_ID=acute_inhalation_2059; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.9059; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 22.7363 | mg/L | - | Inhalation | Duration=20 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=225; Record_ID=acute_inhalation_2058; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=22.7363; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 7.035 | mg/L | - | Inhalation | Duration=0.5 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=226; Record_ID=acute_inhalation_725; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=7.035; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 11.342 | mg/L | - | Inhalation | Duration=0.25 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=227; Record_ID=acute_inhalation_726; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.342; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 18.693 | mg/L | - | Inhalation | Duration=5 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=228; Record_ID=acute_inhalation_727; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=18.693; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15557/7/3/3/?documentUUID=1090d680-6e4d-4c9e-a54e-d972a2edfbf4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 28.0541 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=229; Record_ID=acute_inhalation_2056; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=28.0541; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 31.2876 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=230; Record_ID=acute_inhalation_2055; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=31.2876; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 25.8223 | mg/L | - | Inhalation | Duration=10 min | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=231; Record_ID=acute_inhalation_2054; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=25.8223; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 5.1082 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=232; Record_ID=acute_inhalation_2053; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=5.1082; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 4673 | mg/m3 | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=233; Record_ID=acute_inhalation_1735; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4673; Response_Unit=mg/m3; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
| NTP ICE acute inhalation | LC50 | 6.6132 | mg/L | - | Inhalation | Duration=1 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=234; Record_ID=acute_inhalation_1734; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=6.6132; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | GHS Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=117; Record_ID=eye_irritation_116; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID0023872; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0023872 |
ToxValDB ATSDR MRLs 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ATSDR MRLs | LOAEL | =34.8284 | mg/m3 | Human | inhalation | acute; 2 hours | clinical | LONG_REF=Verberk MM. 1977. Effects of ammonia in volunteers. Int Arch Occup Environ Health 39:73-81.; TITLE=Effects of ammonia in volunteers; AUTHOR=Verberk MM; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp126.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447343:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4cfe6e3b8aafd25400417bd5d31cf630 |
| ToxValDB ATSDR MRLs | MRL | =1.18417 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9d3c75d0f990481175e28c5b9d9df07d |
| ToxValDB ATSDR MRLs | MRL | =0.0696568 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=respiratory; STUDY_GROUP=ATSDR MRLs_dup_-_15446862_15446863:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3124e287f830247182bbe9f1a4673638 |
| ToxValDB ATSDR MRLs | NOAEL | =6.40842 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness DL, Purdham JT, Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am Ind Hyg Assoc J 50:646-650.; TITLE=Acute and chronic respiratory effects of occupational exposure to ammonia; AUTHOR=Holness DL; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f404e4b063812d584c0d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp126.pdf; TOXICOLOGICAL_EFFECT=respiratory; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447344:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4e142f9578b04c6d5d2c7097a05bf5bd |
ToxValDB Cal OEHHA REL derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Cal OEHHA REL derivations | BMC (05) | =9.47332 | mg/m3 | Human | inhalation | acute; 5 minutes | clinical | LONG_REF=Industrial Bio-Test Laboratories, Inc. Report to International Institute of Ammonia Refrigeration: Irritation threshold evaluation study with ammonia. IBT No 1973; 663-03161 (March 23, 1973). MacEwen J, Theodore J, Vernot EH. Human exposure to EEL concentration of monomethylhydrazine. AMRL-TR- 1970; 70-102, 23. Wright-Patterson Air Force Base (OH): SysteMed Corp.; 1970. Silverman L, Whittenberger JL, Muller J. Physiological response of man to ammonia in low concentrations. J Ind Hyg Toxicol 1949;31:74-78. Verberk M. Effects of ammonia in volunteers. Int Arch Occup Health 1977;39:73-81; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=eye and respiratory irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951902:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a04aa4d925e35a13c73dfb9858d4cc5e |
| ToxValDB Cal OEHHA REL derivations | NOAEL | =6.40842 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness DL, Purdham JT, and Nethercott JR. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. Am. Ind. Hyg. Assoc. J. 50(12):646-650.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Pulmonary function, eye, skin, and respiratory symptoms of irritation; STUDY_GROUP=Cal OEHHA REL derivations:15952001:-:-workers in soda ash plant; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cc100f6b5e215b6b51c22dd8fe35a7fd |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =104485 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=DOE Protective Action Criteria:15512100:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0783d0f165af33ba5ab6487cf145460c |
ToxValDB ECOTOX 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | LOEL | =20 | g/kg sd | Rat | oral | short-term; 28 days | short-term | LONG_REF=Drug Chem. Toxicol.21(3): 387-404 Simeone,A., G.A. Boissonneault, L.P. Bush, and G.E.Jr. Mitchell Comparison of Two Ammoniation Procedures to Reduce the Toxicity of Endophyte-Infected Tall Fescue Seed Fed to Rats 1998; TITLE=Comparison of Two Ammoniation Procedures to Reduce the Toxicity of Endophyte-Infected Tall Fescue Seed Fed to Rats; AUTHOR=Simeone,A., G.A. Boissonneault, L.P. Bush, and G.E.Jr. Mitchell; DOI=10.3109/01480549809002213; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112406; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption|Morphology: Organ weight in relationship to body weight|Physiology: Food conversion efficiency; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594447_15595358:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=173f36dbe4871517b9884b8e1a0637d1 |
| ToxValDB ECOTOX | LOEL | =0.1 | % | Rat | oral | short-term; 21 days | short-term | LONG_REF=Digestion57(6): 411-419 Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats 1996; TITLE=Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats; AUTHOR=Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa; DOI=10.1159/000201369; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Collagen to hydroxyproline ratio|Biochemistry: Hydroxyproline|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594740_15594741_15597156:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a7f708075607e2aacc414b540c386cf9 |
| ToxValDB ECOTOX | LOEL | =0.01 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Cancer Lett.65(1): 15-18 Tsujii,M., S. Kawano, S. Tsuji, K. Nagano, T. Ito, N. Hayasahi, H. Fusamoto, T. Kamada, and K. Tamura Ammonia: A Possible Promotor in Helicobacter pylori-Related Gastric Carcinogenesis 1992; TITLE=Ammonia: A Possible Promotor in Helicobacter pylori-Related Gastric Carcinogenesis; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, K. Nagano, T. Ito, N. Hayasahi, H. Fusamoto, T. Kamada, and K. Tamura; DOI=10.1016/0304-3835(92)90207-c; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112436; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595109_15596341:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ba702d09ba5d266418eb434631d28a77 |
| ToxValDB ECOTOX | LOEL | =0.02 | % | Rat | oral | chronic; 168 days | chronic | LONG_REF=Eur. J. Histochem.38(1): 41-52 Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats 1994; TITLE=Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats; AUTHOR=Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112743; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Height|Cell(s): Number of cells; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595144_15597498:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3b225d731b7aceba58667f3218a3b6c6 |
| ToxValDB ECOTOX | LOEL | =187.5 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9abc8ad9afd2ef5c708802f78945b738 |
| ToxValDB ECOTOX | NOEL | =0.1 | % | Rat | oral | subchronic; 84 days | subchronic | LONG_REF=Eur. J. Histochem.38(1): 41-52 Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats 1994; TITLE=Influence of Ammonia Solution on Gastric Mucosa and Acetic Acid Induced Ulcer in Rats; AUTHOR=Hata,M., Y. Yamazaki, T. Ueda, T. Kato, Y. Kohli, and N. Fujiki; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112743; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Physiology: Mucus production; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15594212:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07c371a7a7bb64c7f92cfb6f29aa274b |
| ToxValDB ECOTOX | NOEL | =250 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: Adenosine diphosphate (ADP)|Biochemistry: Adenosine monophosphate (AMP)|Biochemistry: Hemoglobin|Physiology: Blood volume; TOXICOLOGICAL_EFFECT_CATEGORY=hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e8cd9b4305311449b7a237365c474a46 |
| ToxValDB ECOTOX | NOEL | =0.01 | % | Mouse | oral | short-term; 10 days | short-term | LONG_REF=Free Radic. Biol. Med.33(8): 1073-1081 Nagahashi,S., H. Suzuki, M. Miyazawa, H. Nagata, M. Suzuki, S. Miura, and H. Ishii Ammonia Aggravates Stress-Induced Gastric Mucosal Oxidative Injury Through the Cancellation of Cytoprotective Heat Shock Protein 70 2002; TITLE=Ammonia Aggravates Stress-Induced Gastric Mucosal Oxidative Injury Through the Cancellation of Cytoprotective Heat Shock Protein 70; AUTHOR=Nagahashi,S., H. Suzuki, M. Miyazawa, H. Nagata, M. Suzuki, S. Miura, and H. Ishii; DOI=10.1016/s0891-5849(02)00998-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112322; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Heat shock protein 70|Biochemistry: Thiobarbituric acid reactive substances|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594398_15601222:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0a94e39b236171696337b74911ea2f00 |
| ToxValDB ECOTOX | NOEL | =55 | umol/kg-minute | Rat | injection | acute; 0.125 days | acute | LONG_REF=Liver Transplant.10(7): 922-927 Dethloff,T., B.A. Hansen, and F.S. Larsen Tacrolimus Ameliorates Cerebral Vasodilatation and Intracranial Hypertension in the Rat with Portacaval Anastomosis and Hyperammonemia 2004; TITLE=Tacrolimus Ameliorates Cerebral Vasodilatation and Intracranial Hypertension in the Rat with Portacaval Anastomosis and Hyperammonemia; AUTHOR=Dethloff,T., B.A. Hansen, and F.S. Larsen; DOI=10.1002/lt.20141; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=85361; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: CO2 concentration|Biochemistry: Oxygen content|Biochemistry: pH|Physiology: Blood pressure|Physiology: Pressure; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594495_15598684:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=322f69df15dfa0fec1f24067816096de |
| ToxValDB ECOTOX | NOEL | =0.02 | % | Rat | oral | short-term; 21 days | short-term | LONG_REF=Digestion57(6): 411-419 Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats 1996; TITLE=Effects of Intragastric Ammonia on Collagen Metabolism of Gastric Ulcer Base in Rats; AUTHOR=Endo,H., Y. Tsukamoto, T. Arisawa, H. Goto, S. Hase, and T. Hayakawa; DOI=10.1159/000201369; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=112405; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Collagen to hydroxyproline ratio|Biochemistry: Hydroxyproline|Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594740_15594741_15597156:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=08b5eecbb63991345836ce3478b43609 |
| ToxValDB ECOTOX | NOEL | =125 | mM | Rat | oral | acute; 0.0208 days | acute | LONG_REF=Gastroenterology102(6): 1881-1888 Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato Mechanism of Gastric Mucosal Damage Induced by Ammonia 1992; TITLE=Mechanism of Gastric Mucosal Damage Induced by Ammonia; AUTHOR=Tsujii,M., S. Kawano, S. Tsuji, H. Fusamoto, T. Kamada, and N. Sato; DOI=10.1016/0016-5085(92)90309-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113020; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Injury: Ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594329_15595664_15608141_15608142:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d72e6879e59d1d7e85277bc1936bb802 |
ToxValDB EU SCOEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB EU SCOEL | LOAEL | =34.8284 | mg/m3 | Human | inhalation | acute; 360 minutes | clinical | LONG_REF=MacEwen, J.D., Theodore, J., Vernot, E.H. (1970). Human exposure to EEL concentrations of monoethylhydrazine. In: Proceedings of the 1st Annual Conference on Environmental Toxicology, Ohio, Wright-Patterson Air Force Base, 911 September 1970, Aerospace Medical Research Laboratory, pp 355-363 (AMRL-TR70-102, Paper No 23). Industrial Biotest Laboratories, Inc. (1973). Irritation threshold evaluation study with ammonia, IBL Inc. (Report to International Institute of Ammonia Refrigeration, Publ. No. 663-03161. Ferguson, W.S., Koch, W.C., Webster, L.B., Gould, J.R. (1977). Human physiological response and adaptation to ammonia. J. Occup. Med. 19. 319-326. Verberck, M.M. (1977). Effects of ammonia in volunteers. Int. Arch. Occup. Environ. Health 39,73-81.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c985c4e4b02565fc7d399d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu; SUBSOURCE_URL=https://echa.europa.eu/documents/10162/35144386/018_ammonia_oel_en.pdf; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=mild irritation; STUDY_GROUP=EU SCOEL:15952324:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fef51c10f193c12ab5564d1a4445d85b |
ToxValDB GESTIS DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL local | =14 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629794_15629795:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0dd70024d5a41086b67bbed562401b4e |
| ToxValDB GESTIS DNEL | DNEL systemic | =47.6 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629794_15629795:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3969d1d8a22c48f5b366328dad72b6b3 |
ToxValDB HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | LOAEL | =62.6911 | mg/m3 | Rat | inhalation | - | repeat dose other | LONG_REF=Stolpe J, Sedlag R; 1976; Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; Ach. Exper. Vet. Med. 30, 533-539.; TITLE=Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; AUTHOR=Stolpe J, Sedlag R; QUALITY=4; EXTERNAL_SOURCE_ID=64122; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640160_15640221:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_943f266a0c80e62e0c90814bef3e8ab4 |
| ToxValDB HPVIS | NOAEL | =34.8284 | mg/m3 | Rat | inhalation | - | repeat dose other | LONG_REF=Stolpe J, Sedlag R; 1976; Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; Ach. Exper. Vet. Med. 30, 533-539.; TITLE=Die Einzel- und Komplexwirkung von Ammoniak und Schwefelwasserstoff in der Luft auf kleine Versuchstiere (Ratten) bei unterschiedlichen Umweltbedingungen; AUTHOR=Stolpe J, Sedlag R; QUALITY=4; EXTERNAL_SOURCE_ID=60229; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15640160_15640221:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ac1d74e050f574ffc9ccb4b069dfa4dd |
| ToxValDB HPVIS | NOAEL | =24.3799 | mg/m3 | Pig | inhalation | - | reproduction developmental | LONG_REF=Diekman, MA., Scheidt, AB., Sutton, AL., Green, ML., Clapper, JA, Kelly, DT., and Van Alstine, WG. 1993. Growth and reproductive performance, during exposure to ammonia, of gilts afflicted with pneumonia and atrophic rhinitis. Am J Vet Res 54(12):2128-2131.; TITLE=Growth and reproductive performance, during exposure to ammonia, of gilts afflicted with pneumonia and atrophic rhinitis; AUTHOR=Diekman, MA., Scheidt, AB., Sutton, AL., Green, ML., Clapper, JA, Kelly, DT., and Van Alstine, WG; QUALITY=4; EXTERNAL_SOURCE_ID=58070; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=HPVIS:15642343:-:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31b4df8b7490798844c23380c92c632d |
ToxValDB IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB IRIS | NOAEL | =13.6 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS_dup_IRIS Summary_15644284_15644285:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0a768b2c34bbe35f9bacf4567a5f7df2 |
| ToxValDB IRIS | NOAEL (ADJ) | =4.9 | mg/m3 | Human | inhalation | - | occupational | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS_dup_IRIS Summary_15644284_15644285:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_74c2979096afd9eef045cc50f88ff841 |
| ToxValDB IRIS | RfC | =0.5 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Holness, DL; Purdham, JT; Nethercott, JR. (1989). Acute and chronic respiratory effects of occupational exposure to ammonia. AIHA J 50: 646-650. http://dx.doi.org/10.1080/15298668991375308. ; Rahman, MH; Bratveit, M; Moen, BE. (2007). Exposure to ammonia and acute respiratory effects in a urea fertilizer factory. Int J Occup Environ Health 13: 153-159. http://dx.doi.org/10.1179/oeh.2007.13.2.153. ; Ballal, SG; Ali, BA; Albar, AA; Ahmed, HO; Al-Hasan, AY. (1998). Bronchial asthma in two chemical fertilizer producing factories in eastern Saudi Arabia. Int J Tuberc Lung Dis 2: 330-335. ; Ali, BA, Ahmed, HO, Ballal, SG, Albar, AA. (2001). Pulmonary function of workers exposed to ammonia: A study in the Eastern Province of Saudi Arabia. Int J Occup Environ Health 7: 19-22. http://dx.doi.org/10.1179/oeh.2001.7.1.19.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a41e4b045b9ff7a5aaa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=422; TOXICOLOGICAL_EFFECT=reduced lung function and respiratory symptoms; STUDY_GROUP=IRIS:15644286:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_13eade588ff40a5ad96a49818642783a |
ToxValDB NIOSH IDLH 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB NIOSH IDLH | LEL | =348.284 | mg/m3 | Human | inhalation | acute; 30 min | occupational | LONG_REF=Silverman L, Whittenberger JL, Muller J [1946]. Physiological response of man to ammonia in low concentrations. J Ind Hyg Toxicol 31:74-78.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b369e4b02565fc7d6a98; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/7664417.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=change in respiration rate and moderate to severe irritation; STUDY_GROUP=NIOSH IDLH:15953015:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_621ec7a9640e576c947d1c7d8e246c93 |
ToxValDB PPRTV (CPHEA) 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB PPRTV (CPHEA) | NOAEL (HEC) | =2.3 | mg/m3 | Human | inhalation | chronic; 12.2 years | occupational | LONG_REF=Holness et al. 1989; AUTHOR=Holness et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1569; TOXICOLOGICAL_EFFECT=Cardiovascular; STUDY_GROUP=PPRTV (CPHEA):15653383:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a68d65f5d7493113915d48b6c9421e77 |
| ToxValDB PPRTV (CPHEA) | RfC (provisional) | =0.1 | mg/m3 | Human | inhalation | - | Toxicity Value | LONG_REF=Holness et al. 1989; AUTHOR=Holness et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754bee4b08a6b3934b339; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1569; TOXICOLOGICAL_EFFECT=Cardiovascular; STUDY_GROUP=PPRTV (CPHEA):15653382:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a6291cbb92e614581573e5be5de705b7 |
ToxValDB Pennsylvania DEP ToxValues 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB Pennsylvania DEP ToxValues | RfD | =0.85 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67599fbae4b0a7c65d37b2e3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://files.dep.state.pa.us/EnvironmentalCleanupBrownfields/LandRecyclingProgram/LandRecyclingProgramPortalFiles/GuidanceTechTools/VaporIntrusion/November_2021/Table%205a.pdf; STUDY_GROUP=Pennsylvania DEP ToxValues:15649802:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_770efc3cec0b272b0f688de0daab2590 |
ToxValDB TX TCEQ 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB TX TCEQ | LOAEL | =3.48284 | mg/m3 | Human | inhalation | acute; 3 hours | clinical | LONG_REF=Sundblad B-M, B-M Larsson, F Acevedo, L Ernstgard, G Johanson, K Larsson, and L Palmberg. 2004. Acute respiratory effects of exposure to ammonia on health persons. Scandinavian Journal of Work, Environment, & Health 30(4): 313-321; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/ammonia.pdf; YEAR=2014 (revised 2015); ORIGINAL_YEAR=2014 (revised 2015); TOXICOLOGICAL_EFFECT=Mild, transient upper respiratory symptoms and CNS effects (eye discomfort, smell, headache, dizziness, and feelings of intoxication); STUDY_GROUP=TX TCEQ:15954318:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2784e032f3e99f032bef26d11ac4e89e |
| ToxValDB TX TCEQ | NOAEL | =12.5 | ppm | Human | occupational | chronic; 12.2 years | occupational | LONG_REF=Holness DL, JT Purdham, and JR Nethercott. 1989. Acute and chronic respiratory effects of occupational exposure to ammonia. American Industrial Hygiene Association Journal 50(12): 646-650.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/ammonia.pdf; YEAR=2014 (revised 2015); ORIGINAL_YEAR=2014 (revised 2015); STUDY_GROUP=TX TCEQ:15954319:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e8c78352eb2bcb6798b965f0286574e |
openFDA substances 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 5138Q19F1X | UNII | - | - | - | chemical | - |
| openFDA substances | FDA UNII substance identifier | concept | identifier | - | - | - | concept | - |