NOAEL Studies Cosmetic Ingredient

Ammonium Acetate NOAEL Studies

CAS: 631-61-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rabbit oral NA Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 9750 mg/kg bw/day rat oral 100 day Neurotoxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8653; row=8784; data_type=In Vivo; mixture=Chemical; chemical_name=Ammonium acetate; preferred_name=Ammonium acetate; dtxsid=DTXSID5023873; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023873; source_file=acute_oral.xlsx
ToxValDB_ECOTOX 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =1.92 mg/kg bw/day Rat oral subchronic; 56 days subchronic LONG_REF=Neurosci. Lett.231(3): 179-181 Insausti,A.M., J.M. Gaztelu, L.M. Gonzalo, M. Romero-Vives, C. Barrenechea, V. Felipo, and R. Insausti Diet Induced Hyperammonemia Decreases Neuronal Nuclear Size in Rat Entorhinal Cortex 1997; TITLE=Diet Induced Hyperammonemia Decreases Neuronal Nuclear Size in Rat Entorhinal Cortex; AUTHOR=Insausti,A.M., J.M. Gaztelu, L.M. Gonzalo, M. Romero-Vives, C. Barrenechea, V. Felipo, and R. Insausti; DOI=10.1016/s0304-3940(97)00560-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151927; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Area; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15597177:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b08d55622635995c0b35a800b7b1810
ToxValDB_ECOTOX LOEL =3 mmol Rat injection acute; 36 hours short-term LONG_REF=J. Lab. Clin. Med.106(5): 583-588 Zieve,L., R. Dozeman, D. LaFontaine, and K. Draves Effect of Hepatic Failure Toxins on Liver Thymidine Kinase Activity and Ornithine Decarboxylase Activity After Massive Necrosis with Acetaminophen in the Rat 1985; TITLE=Effect of Hepatic Failure Toxins on Liver Thymidine Kinase Activity and Ornithine Decarboxylase Activity After Massive Necrosis with Acetaminophen in the Rat; AUTHOR=Zieve,L., R. Dozeman, D. LaFontaine, and K. Draves; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=99159; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Enzyme(s): Thymidine kinase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15611545:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6d336011337e3787a03d37f1d65019c2
ToxValDB_ECOTOX LOEL =20 g/dl Rat oral short-term; 14 days short-term LONG_REF=Gastroenterology110(3): 801-808 Dial,E.J., L.R. Hall, J.J. Romero, and L.M. Lichtenberger Rats with Gastritis have Increased Sensitivity to the Gastrin Stimulatory Effects of Luminal Ammonia 1996; TITLE=Rats with Gastritis have Increased Sensitivity to the Gastrin Stimulatory Effects of Luminal Ammonia; AUTHOR=Dial,E.J., L.R. Hall, J.J. Romero, and L.M. Lichtenberger; DOI=10.1053/gast.1996.v110.pm8608890; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151841; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Feeding behavior: Food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15598820:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4b0daabd111c78b726061cf91a14e07d
ToxValDB_ECOTOX LOEL =200000 ppm Rat oral short-term; 7 days short-term LONG_REF=Neurochem. Res.18(9): 971-975 Bodega,G., I. Suarez, M.C. Boyano, M. Rubio, R.M. Villalba, E. Arilla, L. Gonzalez-Guijarro, and B. Fernandez High Ammonia Diet: Its Effect on the Glial Fibrillary Acidic Protein (GFAP) 1993; TITLE=High Ammonia Diet: Its Effect on the Glial Fibrillary Acidic Protein (GFAP); AUTHOR=Bodega,G., I. Suarez, M.C. Boyano, M. Rubio, R.M. Villalba, E. Arilla, L. Gonzalez-Guijarro, and B. Fernandez; DOI=10.1007/BF00966755; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151921; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15594556:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9935e054344ee40d33e78dbad80dd42a
ToxValDB_ECOTOX NOEL =20 % Rat oral chronic; 182 days chronic LONG_REF=J. Gastroenterol.32(4): 435-441 Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis 1997; TITLE=Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis; AUTHOR=Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi; DOI=10.1007/BF02934080; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151911; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Cell changes|Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598363_15607798:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ce26dcce0fd3594931e53f276d0fd986
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =9.11 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629801_15629802:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e521b5a7db725c4fe8e3393dfb44567
ToxValDB_GESTIS_DNEL DNEL systemic =911.56 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15629801_15629802:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_37d16f7d7677778ff148c40e2bf8e33b
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RRE756S6Q2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RRE756S6Q2"}
openFDA substances FDA UNII substance identifier RRE756S6Q2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RRE756S6Q2"}
openFDA substances FDA UNII substance identifier RRE756S6Q2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RRE756S6Q2"}
openFDA substances FDA UNII substance identifier RRE756S6Q2 UNII - - - chemical {"approval_status":null,"molecular_formula":"C2H3O2.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RRE756S6Q2"}