Ammonium Acetate
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Ammonium Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 9750 mg/kg bw/day | oral | rat | Neurotoxicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rabbit | Special Toxicology Study | COSMOS_DB |
| NOAEL | >=0.047 other | oral | - | oral | REACH |
| NOAEL | >=3382.76 other | oral | - | oral | REACH |
| NOAEL | >=19.73 other | oral | - | oral | REACH |
| NOAEL | >=0.0094 other | oral | - | oral | REACH |
| NOAEL | >=54 other | oral | - | oral | REACH |
| NOAEL | >=0.05 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=3600 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=21 other | oral | rat | oral | REACH |
Expert Verdict
Ammonium acetate is a buffering agent generally considered low hazard at cosmetic use levels with adequate margin of safety.
Regulatory Flags
Frequently Asked Questions
Is Ammonium Acetate safe in cosmetics?
Ammonium acetate is a buffering agent generally considered low hazard at cosmetic use levels with adequate margin of safety. The EU classifies Ammonium Acetate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Ammonium Acetate allowed in the EU?
Ammonium Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Acetate do in cosmetics?
Ammonium Acetate functions as: Catalyst; Thickening agent; pH regulating agent. It is classified as a cosmetic ingredient in our database. CAS number: 631-61-8.
What is the Margin of Safety for Ammonium Acetate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Ammonium Acetate?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Acetate is 9750 mg/kg bw/day based on a Neurotoxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Ammonium Acetate compliance across multiple jurisdictions:
Related Ingredients
Is Ammonium Acetate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ammonium Acetate in your formulation.