Good Cosmetic Ingredient NOAEL Data GHS Classified

Ammonium Bicarbonate

INCI: AMMONIUM BICARBONATE

CAS Number
1066-33-7
Function
Buffering (pH control)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR: safe as used when formulated to be non-irritating; FDA GRAS as food additive

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Ammonium Bicarbonate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 12300 ppm oral rat oral REACH
NOAEL ca.1695.7 mg/kg bw/day oral rat oral REACH
NOAEL ca.2214.5 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.

Expert Verdict

Potential skin/eye irritant at high concentrations; used up to 93.4% in rinse-off hair bleach; formulate to be non-irritating

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Concern Level: Low

Regulatory Flags

epa_safer_alternative fda_food_additive

Frequently Asked Questions

Is Ammonium Bicarbonate safe in cosmetics?

Potential skin/eye irritant at high concentrations; used up to 93.4% in rinse-off hair bleach; formulate to be non-irritating The EU classifies Ammonium Bicarbonate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Ammonium Bicarbonate allowed in the EU?

Ammonium Bicarbonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ammonium Bicarbonate do in cosmetics?

Ammonium Bicarbonate functions as: Buffering (pH control). It is classified as a cosmetic ingredient in our database. CAS number: 1066-33-7.

What is the Margin of Safety for Ammonium Bicarbonate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ammonium Bicarbonate?

The NOAEL (No Observed Adverse Effect Level) for Ammonium Bicarbonate is 12300 ppm based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

Compliance Tools

Check Ammonium Bicarbonate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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