NOAEL Studies
Cosmetic Ingredient
Ammonium Dodecylbenzenesulfonate NOAEL Studies
INCI: AMMONIUM DODECYLBENZENESULFONATE
CAS: 1331-61-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =0.2 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_002"} |
| CIR Safety Assessment | NOAEL | =0.2 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_002"} |
| CIR Safety Assessment | NOAEL | =0.2 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_002"} |
| CIR Safety Assessment | NOAEL | =0.2 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_002"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_003"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_003"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_003"} |
| CIR Safety Assessment | NOAEL | =1 | % | rat | oral | 6 months | repeated dose toxicity | {"citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group","page":10,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_003"} |
| CIR Safety Assessment | NOAEL | =100 | mg/kg | dog | - | chronic | NOAEL study | {"citation":"10; 100; 22","dose":"body weight gain for females of the 1000 mg/kg per d group compared with controls.","effect":"body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4)","page":9,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_001"} |
| CIR Safety Assessment | NOAEL | =100 | mg/kg | dog | - | chronic | NOAEL study | {"citation":"10; 100; 22","dose":"body weight gain for females of the 1000 mg/kg per d group compared with controls.","effect":"body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4)","page":9,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_001"} |
| CIR Safety Assessment | NOAEL | =100 | mg/kg | dog | - | chronic | NOAEL study | {"citation":"10; 100; 22","dose":"body weight gain for females of the 1000 mg/kg per d group compared with controls.","effect":"body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4)","page":9,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_001"} |
| CIR Safety Assessment | NOAEL | =100 | mg/kg | dog | - | chronic | NOAEL study | {"citation":"10; 100; 22","dose":"body weight gain for females of the 1000 mg/kg per d group compared with controls.","effect":"body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4)","page":9,"pdf":"PRS544.pdf","row_type":"noael_study","study_id":"PRS544_noael_001"} |
ECHA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =350 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b65f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24944/7/9/2?documentUUID=d84c77bf-c195-414e-a82b-b38065926996; YEAR=2005; ORIGINAL_YEAR=2005; STUDY_GROUP=ECHA IUCLID:15857918:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eb8b7e116a781706262a3f2286a19ec8 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =10 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629813:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcd9c13c28b08d9ee8bb11d1e9c03edc |
Regulatory source 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 100 | mg/kg | dog | - | chronic | - | SOURCE_SUBDIR=PRS544; REPORT_TITLE=Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics; OPINION_NUMBER=PRS544; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=16 In 1987; VALUE_TEXT=100 and 1000; DOSE=body weight gain for females of the 1000 mg/kg per d group compared with controls.; EFFECT=body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4); CITATION=10; 100; 22; CITATION_NUMBERS=[10,100,22]; REFERENCE=10; 100; 22; DETAILS_JSON={"cas_number":"1331-61-9","citation":"10; 100; 22","dose":"body weight gain for females of the 1000 mg/kg per d group compared with controls.","duration":"chronic","effect":"body weight gain for females of the 1000 mg/kg per d group compared with controls. There was no difference between treated and control groups in hematologic or urine chemistry values. At microscopic exam- ination, hemorrhagic necrosis of the intestine and infiltration of chronic inflammatory cells were observed in dogs given 10 mg/kg and hemosiderosis of the liver and spleen was observed in dogs administered 100 and 1000 mg/kg.22 Sodium alkylbenzene sulfonate. Freeman et al33 reported a no observed effects level (NOEL) of 1 g/d for 6 months for dogs orally administered sodium alkylbenzene sulfonate. 296S International Journal of Toxicology 29(Supplement 4)","endpoint":"","ingredient":"Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts","loael_value":"","noael_unit":"mg/kg","noael_value":"100 and 1000","page":9,"route":"","species":"dog","study_id":"PRS544_noael_001"} |
| Regulatory source | repeated dose toxicity | 0.2 | % | rat | oral | 6 months | repeated dose toxicity | SOURCE_SUBDIR=PRS544; REPORT_TITLE=Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics; OPINION_NUMBER=PRS544; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=16 In 1987; VALUE_TEXT=0.2; DOSE=Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.; EFFECT=Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump; CITATION=0; 2; 6; CITATION_NUMBERS=[2,6]; REFERENCE=0; 2; 6; DETAILS_JSON={"cas_number":"1331-61-9","citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","duration":"6 months","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consump","endpoint":"repeated dose toxicity","ingredient":"Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts","loael_value":"","noael_unit":"%","noael_value":"0.2","page":10,"route":"oral","species":"rat","study_id":"PRS544_noael_002"} |
| Regulatory source | repeated dose toxicity | 1 | % | rat | oral | 6 months | repeated dose toxicity | SOURCE_SUBDIR=PRS544; REPORT_TITLE=Amended Safety Assessment of Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts as Used in Cosmetics; OPINION_NUMBER=PRS544; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=16 In 1987; VALUE_TEXT=1.0; DOSE=Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.; EFFECT=Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group; CITATION=0; 2; 6; CITATION_NUMBERS=[2,6]; REFERENCE=0; 2; 6; DETAILS_JSON={"cas_number":"1331-61-9","citation":"0; 2; 6","dose":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs.","duration":"6 months","effect":"Woodard and Calvery45 reported a NOEL of 0.2% sodium alkylbenzene sulfonate administered in drinking water for 6 months for guinea pigs. Fitzhugh and Nelson46 reported a NOEL of 1.0% sodium alkylbenzene sulfonate administered in feed for 16 weeks for rats. Rats fed 4% sodium alkylbenzene sulfonate had severe bloating and diarrhea, grew very little and died within the first week of the experiment. Linear alkylbenzene sulfonates. Three groups of Sprague- Dawley rats (10 males and 10 females per group) were fed a diet containing 0.02%, 0.1%, or 0.5% LAS for 90 days.47 A control group of 20 rats was fed untreated diet for the same time period. Body weights and feed consumption were measured weekly. Hematologic studies and urinalysis were performed on samples taken from 5 males and 5 females from each group","endpoint":"repeated dose toxicity","ingredient":"Dodecylbenzenesulfonate, Decylbenzenesulfonate, and Tridecylbenzenesulfonate Salts","loael_value":"","noael_unit":"%","noael_value":"1.0","page":10,"route":"oral","species":"rat","study_id":"PRS544_noael_003"} |