NOAEL Studies
Cosmetic Ingredient
Ammonium Nitrate NOAEL Studies
INCI: AMMONIUM NITRATE
CAS: 6484-52-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_eye_irritation 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 18.3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=796; Record_ID=eye_irritation_203; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=18.3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=801; Record_ID=eye_irritation_33; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
| NTP_ICE_eye_irritation | GHS Classification | 2 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=802; Record_ID=eye_irritation_33; Data_Type=In Vivo; Concentration=100.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=2B; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
| NTP_ICE_eye_irritation | Intensity | 2.07 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=800; Record_ID=eye_irritation_1271; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Vitrigel; Endpoint=Intensity; Response=2.07; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=797; Record_ID=eye_irritation_1271; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
| NTP_ICE_eye_irritation | Plateau level | 62 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=798; Record_ID=eye_irritation_1271; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2029668; Assay=Vitrigel; Endpoint=Plateau level; Response=62; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2029668 |
ToxValDB_ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =1 | mg/L | Mouse | environmental | short-term; 4 days | developmental | LONG_REF=Environ. Health Perspect.112(6): 703-709 Greenlee,A.R., T.M. Ellis, and R.L. Berg Low-Dose Agrochemicals and Lawn-Care Pesticides Induce Developmental Toxicity in Murine Preimplantation Embryos 2004; TITLE=Low-Dose Agrochemicals and Lawn-Care Pesticides Induce Developmental Toxicity in Murine Preimplantation Embryos; AUTHOR=Greenlee,A.R., T.M. Ellis, and R.L. Berg; DOI=10.1289/ehp.6774; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=82041; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Development: Organ/tissue formation|Genetics: Apoptosis; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606913_15607311:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=49ae2af6aadde0afbaa2c5874fdad697 |
| ToxValDB_ECOTOX | NOEL | =100 | mg/kg bw/day | Mouse | injection | subchronic; 35 days | subchronic | LONG_REF=Biologija(2): 20-22 Morkunas,V., and R. Lekevicius Investigation of Natural Genetic Variability and Mutations in Common Voles (Microtus arvalis Pallas) and Laboratory Mice Induced by Polychlorinated Biphenyls and Ammonium Nitrate 2003; TITLE=Investigation of Natural Genetic Variability and Mutations in Common Voles (Microtus arvalis Pallas) and Laboratory Mice Induced by Polychlorinated Biphenyls and Ammonium Nitrate; AUTHOR=Morkunas,V., and R. Lekevicius; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=96415; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Reproduction: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX:15608119:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=57b3059a8ea6cc649d789767fa3d02d2 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =36 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629827:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6ba42c9014df5674760b7365f085362 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | T8YA51M7Y6 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO3.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T8YA51M7Y6"} |
| openFDA substances | FDA UNII substance identifier | T8YA51M7Y6 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO3.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T8YA51M7Y6"} |
| openFDA substances | FDA UNII substance identifier | T8YA51M7Y6 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO3.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T8YA51M7Y6"} |
| openFDA substances | FDA UNII substance identifier | T8YA51M7Y6 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO3.H4N","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"T8YA51M7Y6"} |