NOAEL Studies Cosmetic Ingredient

Ammonium Persulfate NOAEL Studies

INCI: AMMONIUM PERSULFATE

CAS: 7727-54-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR Safety Assessment 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR Safety Assessment NOAEL =5 mg/m3 rat oral - developmental toxicity 10; 3; 5, p.8
CIR Safety Assessment NOAEL =10.3 mg/m3 rat oral 13 wk developmental toxicity 13; 200; 91, p.14
CIR Safety Assessment NOAEL =25 mg/m3 rat inhalation 13 weeks inhalation toxicity 25; 13; 6, p.7
CIR Safety Assessment NOAEL =41.1 mg/kg bw/d rat oral 28-d inhalation toxicity 10; 28; 15, p.6
CIR Safety Assessment NOAEL >80 mg/kg bw rat oral 13-wk repeated dose toxicity (5, 20, 80; 80; 13, p.7
CIR Safety Assessment NOAEL =131.5 mg/kg bw/d rat oral 28-d inhalation toxicity 41; 1; 28, p.6
CIR Safety Assessment NOAEL =200 mg/kg bw/d rat oral 13 week repeated dose toxicity 13; 50; 300, p.7
CIR Safety Assessment NOAEL =250 mg/kg/d - - - reproductive toxicity 4; 250; 1, p.8
NTP ICE acute inhalation 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute inhalation LC50 >=2.95 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5161; Record_ID=acute_inhalation_883; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9029691; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>=; Response=2.95; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14389/7/3/3/?documentUUID=e5bbb920-6e5b-4a9e-9673-debad95b11a2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029691
NTP ICE acute inhalation LC50 >5.1 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5160; Record_ID=acute_inhalation_881; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9029691; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14389/7/3/3/?documentUUID=8433bf2e-05e6-48e9-a7e3-ea2f0a010ebe; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029691
NTP ICE acute inhalation LC50 >42.9 mg/L - Inhalation Duration=1 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=5162; Record_ID=acute_inhalation_887; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9029691; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=42.9; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14389/7/3/3/?documentUUID=a036fe33-dd2b-4644-8edf-7b2cbe501657; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029691
NTP ICE skin sensitization 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization EC3 2 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=13202; Record_ID=skin_sensitization_invivo_3259; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID9029691; Assay=LLNA; Endpoint=EC3; Response=2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Cruz et al. 2009; 19207378; 10.1111/j.1600-0536.2008.01477.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9029691
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL local =0.824 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630999:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dfb1ae134cd99ba6d71aedb72863906f
Regulatory source 9 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source developmental toxicity 5 mg/m3 rat oral - developmental toxicity p.8
Regulatory source developmental toxicity 5 mg/m3 rat oral 13 wk developmental toxicity p.14
Regulatory source developmental toxicity 10.3 mg/m3 rat oral 13 wk developmental toxicity p.14
Regulatory source inhalation toxicity 25 mg/m3 rat inhalation 13 weeks inhalation toxicity p.7
Regulatory source inhalation toxicity 41.1 mg/kg bw/d rat oral 28-d inhalation toxicity p.6
Regulatory source inhalation toxicity 131.5 mg/kg bw/d rat oral 28-d inhalation toxicity p.6
Regulatory source repeated dose toxicity >80 mg/kg bw rat oral 13-wk repeated dose toxicity p.7
Regulatory source repeated dose toxicity 200 mg/kg bw/d rat oral 13 week repeated dose toxicity p.7
Regulatory source reproductive toxicity >=250 mg/kg/d - - - reproductive toxicity p.8
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 22QF6L357F UNII - - - chemical -