Also known as: Peroxydisulfuric acid, diammonium salt, EINECS 231-786-5, Persulfate d'ammonium, UNII-22QF6L357F
INCI: AMMONIUM PERSULFATE
Ammonium Persulfate (CAS 7727-54-0) is a cosmetic cosmetic ingredient functioning as Oxidizing Agent, Bleaching Agent. NOAEL 41.1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ammonium Persulfate is classified GHS Danger (H272, H302, H315, H317, H319, H334, H335, H320) in the chemicals database but is allowed in EU cosmetics.
US NotesNot prohibited or specifically restricted by FDA for cosmetic use; 157 ingredient uses reported to FDA VCRP, 151 of which are in hair coloring/lightening products. CIR Expert Panel (2022 Amended Assessment, Int. J. Toxicol.) concluded safe as used as oxidizing agent in rinse-off hair colorants and lighteners; data insufficient to conclude safety in leave-on products and dentifrices.
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Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ammonium Persulfate.
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Toxicological Studies
10 study endpoints found for Ammonium Persulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
Endpoint
Value
Route
Species
Study Type
Source
NOAEL
=41.1 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=41.1 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=41.1 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=41.1 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=131.5 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=131.5 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=131.5 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=131.5 mg/kg bw/d
oral
rat
inhalation toxicity
CIR Safety Assessment
NOAEL
=200 mg/kg bw/d
oral
rat
repeated dose toxicity
CIR Safety Assessment
NOAEL
=200 mg/kg bw/d
oral
rat
repeated dose toxicity
CIR Safety Assessment
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Inhalation of dust may cause asthma-like reactions.
Long-term Exposure Effects
Repeated or prolonged inhalation may cause asthma. Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. May cause a general allergic reaction, such as urticaria or shock.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety Assessment
Verdict: unknown
NOAEL: 41.1 mg/kg bw/d (oral)
CIR Safety Assessment
Verdict: unknown
NOAEL: 131.5 mg/kg bw/d (oral)
CIR Safety Assessment
Verdict: unknown
NOAEL: 80 mg/kg bw (oral)
CIR Safety Assessment
Verdict: unknown
NOAEL: 10.3 mg/m3 (inhalation)
CIR Safety Assessment
Verdict: unknown
NOAEL: 250 mg/kg/d (not specified)
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ammonium Persulfate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
EU status:restricted (exposure limit; EU 2022/1181)
modulator (thyroid oxidative pathway)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification:Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
Jurisdiction
Status
Max %
Product Type
IN
restricted
11.0
hair bleaching powder products
Additional Ingredient Properties
1 property record from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0632
Source: WHO/JECFA
Skin Eye Respiratory Irritation
Exposure can irritate the skin, eyes, nose, throat adn lungs. Exposure may cause an allergy like reaction, with eye tearing, nose congestion, asthma like wheezing and difficulty in breathing. Life threatening shock may result.
inert_ingredient; non_food_use; Pesticidesfrackingfood_additive; Substances Added to Food (formerly EAFUS) (2/2019)fracking; water
Australian Status
AICIS status:listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCEChEMBL / DrugCentral / FAERSDB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Ammonium Persulfate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Is Ammonium Persulfate allowed in the EU?
Ammonium Persulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ammonium Persulfate do in cosmetics?
Ammonium Persulfate functions as: Oxidizing Agent, Bleaching Agent. It is classified as a cosmetic ingredient in our database. CAS number: 7727-54-0.
What is the NOAEL for Ammonium Persulfate?
The NOAEL (No Observed Adverse Effect Level) for Ammonium Persulfate is =41.1 mg/kg bw/d based on a inhalation toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: CIR Safety Assessment.
Is Ammonium Persulfate used outside cosmetics?
Ammonium Persulfate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ammonium Persulfate have different safety status in cosmetics vs industrial chemicals?
Ammonium Persulfate is classified GHS Danger (H272, H302, H315, H317, H319, H334, H335, H320) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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