NOAEL Studies Cosmetic Ingredient

Ammonium Silver Zinc Aluminum Silicate NOAEL Studies

INCI: AMMONIUM SILVER ZINC ALUMINUM SILICATE

CAS: 130328-20-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =0.0045 mg/kg bw/d human inhalation 90-day NOAEL study p.25
SCCS Opinion NOAEL =0.0065 mg/kg bw/d human oral 70 years NOAEL study p.24
SCCS Opinion NOAEL =0.04 - - inhalation - NOAEL study p.18
SCCS Opinion NOAEL =3.3 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =3.5 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =4.5 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =5 % rat oral 24 months NOAEL study p.24
SCCS Opinion NOAEL =5 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =20 - - oral developmental reproductive toxicity p.26
SCCS Opinion NOAEL =31 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =31.52 mg/kg bw human oral - NOAEL study p.25
SCCS Opinion NOAEL =50 mg/kg bw/day rat - subchronic repeated dose toxicity Ref: Teunissen 2003, p.23
SCCS Opinion NOAEL =100 mg/kg bw/d rat - developmental developmental toxicity p.26
SCCS Opinion NOAEL =200 mg/kg bw/d human oral - reproductive toxicity p.30
SCCS Opinion NOAEL =250 mg/kg bw/d dog - subchronic repeated dose toxicity Ref: Teunissen 2003, p.23
SCCS Opinion NOAEL =275 - - dermal - NOAEL study p.31
SCCS Opinion NOAEL =1000 mg/kg bw - oral developmental reproductive toxicity p.33
SCCS Opinion NOAEL =1109 mg/kg bw rat oral - reproductive toxicity p.26
SCCS Opinion NOAEL =2011 - - oral developmental reproductive toxicity p.26
SCCS Opinion NOAEL =2017 - - dermal - NOAEL study p.31
Regulatory source 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 0.0045 mg/kg bw/d human inhalation 90-day - p.25
Regulatory source - 0.0065 mg/kg bw/d human oral 70 years - p.24
Regulatory source - 0.04 - - inhalation - - p.18
Regulatory source - 3.3 - - dermal - - p.31
Regulatory source - 3.5 - - dermal - - p.31
Regulatory source - 4.5 - - dermal - - p.31
Regulatory source - 5 % rat oral 24 months - p.24
Regulatory source - 5 - - dermal - - p.31
Regulatory source - 31 - - dermal - - p.31
Regulatory source - 31.52 mg/kg bw human oral - - p.25
Regulatory source - 275 - - dermal - - p.31
Regulatory source - 2017 - - dermal - - p.31
Regulatory source developmental toxicity 100 mg/kg bw/d rat - developmental developmental toxicity p.26
Regulatory source repeated dose toxicity 0.0045 mg/kg bw/d rat inhalation chronic repeated dose toxicity p.33
Regulatory source repeated dose toxicity 50 mg/kg bw/day rat - subchronic repeated dose toxicity p.23
Regulatory source repeated dose toxicity 250 mg/kg bw/d dog - subchronic repeated dose toxicity p.23
Regulatory source reproductive toxicity 20 - - oral developmental reproductive toxicity p.26
Regulatory source reproductive toxicity 200 mg/kg bw/d human oral - reproductive toxicity p.30
Regulatory source reproductive toxicity 1000 mg/kg bw - oral developmental reproductive toxicity p.33
Regulatory source reproductive toxicity 1109 mg/kg bw rat oral - reproductive toxicity p.26
Regulatory source reproductive toxicity 2011 - - oral developmental reproductive toxicity p.26