NOAEL Studies
Cosmetic Ingredient
Amyl Acetate NOAEL Studies
INCI: AMYL ACETATE
CAS: 628-63-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR Safety Assessment 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR Safety Assessment | NOAEL | =1000 | mg/kg | rat | - | - | NOAEL study | (53); 98; 100, p.9 |
NTP ICE acute oral 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >1600 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8616; row=2801; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =6500 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8618; row=2799; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =12306 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8620; row=2800; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >14064 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8622; row=2798; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | =17250 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8624; row=2797; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12990; RecordID=ARPathway2016_1422; DatasetName=ARPathway2016; DTXSID=DTXSID1027263; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9187; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263 |
| NTP ICE skin sensitization | Induction dose per skin area | 21260 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9185; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=21260; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263 |
| NTP ICE skin sensitization | Relative reliability score | 2 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=9191; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263 |
ToxValDB DOE Protective Action Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB DOE Protective Action Criteria | LEL | =58571.1 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15512263:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49d18f766f9632957aff660f0d6ae36a |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 92Q24NH7AS | UNII | - | - | - | chemical | - |