NOAEL Studies Cosmetic Ingredient

Amyl Acetate NOAEL Studies

INCI: AMYL ACETATE

CAS: 628-63-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =1000 mg/kg rat - - NOAEL study {"citation":"(53); 98; 100","dose":"Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts.","effect":"me, specific gravity, appearance, number of cells, and content of albumin, glucose, ketone, bile salts, and blood. Serum was analyzed for urea, glucose, total protein, and albumin, as well as for the activities of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic dehydrogenase. Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts. Based upon all the data, the authors concluded that the “no-effect” level for n-amyl alcohol in the rat is, like that for isoamyl alcohol, at least 1000 mg/kg per day.(53) Mutagenicity Amyl Acetate was not a mutagen in the Ames assay, either with or without metabolic activation in Salmonella typhimurium strains TA-1538, TA-98, TA- 1535, TA-100, and TA-1 537.(49) lsoamyl Acetate was negative for mutagenesis in the recombinant assay test in Bacillus subtilis M45 (ret-) and HI7 (ret+) strains.(54) lsoamyl Acetate was also negative for mutagenesis when tested in Saccharomyces cerevisiae strain D61.M.(55) No mutagenicity was found...","page":9,"pdf":"pr149.pdf","row_type":"noael_study","study_id":"pr149_noael_001"}
CIR_vision_codex NOAEL =1000 mg/kg rat - - NOAEL study {"citation":"(53); 98; 100","dose":"Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts.","effect":"me, specific gravity, appearance, number of cells, and content of albumin, glucose, ketone, bile salts, and blood. Serum was analyzed for urea, glucose, total protein, and albumin, as well as for the activities of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic dehydrogenase. Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts. Based upon all the data, the authors concluded that the “no-effect” level for n-amyl alcohol in the rat is, like that for isoamyl alcohol, at least 1000 mg/kg per day.(53) Mutagenicity Amyl Acetate was not a mutagen in the Ames assay, either with or without metabolic activation in Salmonella typhimurium strains TA-1538, TA-98, TA- 1535, TA-100, and TA-1 537.(49) lsoamyl Acetate was negative for mutagenesis in the recombinant assay test in Bacillus subtilis M45 (ret-) and HI7 (ret+) strains.(54) lsoamyl Acetate was also negative for mutagenesis when tested in Saccharomyces cerevisiae strain D61.M.(55) No mutagenicity was found...","page":9,"pdf":"pr149.pdf","row_type":"noael_study","study_id":"pr149_noael_001"}
CIR_vision_codex NOAEL =1000 mg/kg rat - - NOAEL study {"citation":"(53); 98; 100","dose":"Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts.","effect":"me, specific gravity, appearance, number of cells, and content of albumin, glucose, ketone, bile salts, and blood. Serum was analyzed for urea, glucose, total protein, and albumin, as well as for the activities of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic dehydrogenase. Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts. Based upon all the data, the authors concluded that the “no-effect” level for n-amyl alcohol in the rat is, like that for isoamyl alcohol, at least 1000 mg/kg per day.(53) Mutagenicity Amyl Acetate was not a mutagen in the Ames assay, either with or without metabolic activation in Salmonella typhimurium strains TA-1538, TA-98, TA- 1535, TA-100, and TA-1 537.(49) lsoamyl Acetate was negative for mutagenesis in the recombinant assay test in Bacillus subtilis M45 (ret-) and HI7 (ret+) strains.(54) lsoamyl Acetate was also negative for mutagenesis when tested in Saccharomyces cerevisiae strain D61.M.(55) No mutagenicity was found...","page":9,"pdf":"pr149.pdf","row_type":"noael_study","study_id":"pr149_noael_001"}
CIR_vision_codex NOAEL =1000 mg/kg rat - - NOAEL study {"citation":"(53); 98; 100","dose":"Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts.","effect":"me, specific gravity, appearance, number of cells, and content of albumin, glucose, ketone, bile salts, and blood. Serum was analyzed for urea, glucose, total protein, and albumin, as well as for the activities of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic dehydrogenase. Hematologic stud- ies included analyses of hemoglobin concentration, packed cell volume, erythrocyte and leukocyte counts, and differential leukocyte counts. Based upon all the data, the authors concluded that the “no-effect” level for n-amyl alcohol in the rat is, like that for isoamyl alcohol, at least 1000 mg/kg per day.(53) Mutagenicity Amyl Acetate was not a mutagen in the Ames assay, either with or without metabolic activation in Salmonella typhimurium strains TA-1538, TA-98, TA- 1535, TA-100, and TA-1 537.(49) lsoamyl Acetate was negative for mutagenesis in the recombinant assay test in Bacillus subtilis M45 (ret-) and HI7 (ret+) strains.(54) lsoamyl Acetate was also negative for mutagenesis when tested in Saccharomyces cerevisiae strain D61.M.(55) No mutagenicity was found...","page":9,"pdf":"pr149.pdf","row_type":"noael_study","study_id":"pr149_noael_001"}
NTP_ICE_acute_oral 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >1600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_8616; row=2801; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =6500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8618; row=2799; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =12306 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8620; row=2800; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >14064 mg/kg bw Rat (Male) oral acute Rat Acute Oral Toxicity record_id=acute_oral_8622; row=2798; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =17250 mg/kg bw Rat (Female) oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_8624; row=2797; data_type=In Vivo; mixture=Chemical; chemical_name=Pentyl acetate; preferred_name=Pentyl acetate; dtxsid=DTXSID1027263; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12990; RecordID=ARPathway2016_1422; DatasetName=ARPathway2016; DTXSID=DTXSID1027263; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9187; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263
NTP_ICE_skin_sensitization Induction dose per skin area 21260 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9185; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=21260; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263
NTP_ICE_skin_sensitization Relative reliability score 2 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test sheet=Data_invivo; excel_row=9191; Record_ID=skin_sensitization_invivo_2031; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1027263; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=2; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Ford et al. 1988; 3264801; 10.1016/0278-6915(88)90090-7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1027263
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =58571.1 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=DOE Protective Action Criteria:15512263:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49d18f766f9632957aff660f0d6ae36a
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 92Q24NH7AS UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"92Q24NH7AS"}
openFDA substances FDA UNII substance identifier 92Q24NH7AS UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"92Q24NH7AS"}
openFDA substances FDA UNII substance identifier 92Q24NH7AS UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"92Q24NH7AS"}
openFDA substances FDA UNII substance identifier 92Q24NH7AS UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"92Q24NH7AS"}