Is Amyl Acetate safe in cosmetics?
Amyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.
Amyl Acetate
Also known as: n-Amyl acetate, Acetic acid, pentyl ester, 4-02-00-00152, n-Amyl acetate, normal, Amyl acetic ester (+15 more)
INCI: AMYL ACETATE
Amyl Acetate (CAS 628-63-7) is a cosmetic cosmetic ingredient functioning as Solvent, Fragrance. Reported NOAEL =1000 mg/kg in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (cir). Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 628-63-7 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, Fragrance
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR-assessed as safe in present practices of use and concentration (original 1988, reaffirmed)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Amyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =1000 mg/kg | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =1000 mg/kg | - | rat | NOAEL study | CIR_vision_codex |
| NOAEL | =1000 mg/kg | - | rat | NOAEL study | CIR_vision_codex |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. Exposure at high levels could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
cir
Number
6, 1988
Verdict: unknown
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 21259.84 | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Solubility enhancer
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Amyl Acetate.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Amyl Acetate by CAS number or substance name.
Studies
4
Lowest NOAEL
1000 mg/kg
Highest NOAEL
1000 mg/kg
CIR_vision_codex
Known Synonyms
n-Amyl acetate
Acetic acid, pentyl ester
4-02-00-00152
n-Amyl acetate, normal
Amyl acetic ester
BRN 1744753
Caswell No. 049A
Dymon SWH Wasp & Hornet Spray
EINECS 211-047-3
EPA Pesticide Chemical Code 000169
Holiday Pet Repellent
Holiday Repellent Dust
Pent-acetate
Pent-acetate 28
Prim-amyl acetate
Acetate d'amyle
Amylazetat
Amylester kyseliny octove
Octan amylu
UNII-92Q24NH7AS
Chemical Function
Solvent
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
SCIL (9/2019)
IFRA Transparency
Europe
consumer_product
Europe; Specialty occupational products
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Amyl Acetate allowed in the EU?
Amyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Amyl Acetate do in cosmetics?
Amyl Acetate functions as: Solvent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 628-63-7.
What is the NOAEL for Amyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Amyl Acetate is =1000 mg/kg based on a NOAEL study study via oral route in rat. A total of 4 study endpoints are available. Source: CIR_vision_codex.
Compliance Tools
Check Amyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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