NOAEL Studies Cosmetic Ingredient

Anisaldehyde (p-Methoxybenzaldehyde) NOAEL Studies

INCI: ANISALDEHYDE

CAS: 123-11-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 196 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =20 mg/kg bw/day Rat oral: gavage 42 days subchronic EFSA FEEDAP - 2012 - OutputID 607 - body weight - systemic - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1510 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_2013; row=4209; data_type=In Vivo; mixture=Chemical; chemical_name=4-Methoxybenzaldehyde; preferred_name=4-Methoxybenzaldehyde; dtxsid=DTXSID2026997; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026997; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2026997; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=3962; RecordID=ARPathway2016_712; DatasetName=ARPathway2016; DTXSID=DTXSID2026997; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026997; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2026997
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4549; Record_ID=skin_sensitization_invivo_1092; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2026997; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90136-9|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026997; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2026997
NTP_ICE_skin_sensitization Induction dose per skin area 6480 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4547; Record_ID=skin_sensitization_invivo_1092; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2026997; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6480; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90136-9|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026997; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2026997
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=4553; Record_ID=skin_sensitization_invivo_1092; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2026997; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1973: report to RlFM|Opdyke 1974; Not available; 10.1016/0015-6264(74)90136-9|Api et al. 2017; 28691948; 10.1097/der.0000000000000304; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2026997; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2026997
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =50 mg/kg bw/day Mouse injection acute; 0.0607 days acute LONG_REF=J. Agric. Food Chem.30(3): 563-568 Marcus,C., and E.P. Lichtenstein Interactions of Naturally Occurring Food Plant Components with Insecticides and Pentobarbital in Rats and Mice 1982; TITLE=Interactions of Naturally Occurring Food Plant Components with Insecticides and Pentobarbital in Rats and Mice; AUTHOR=Marcus,C., and E.P. Lichtenstein; DOI=10.1021/jf00111a038; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=111962; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Behavior: Sleeping time, induced; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECOTOX:15597609:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=59735527713e282878b3cf8215ef086a
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =20 mg/kg bw/day Rat oral subchronic; 42 days subchronic LONG_REF=EFSA FEEDAP (2012). Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species. doi:10.2903/j.efsa.2012.2785.; TITLE=Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2012.2785; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15614505:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_69bb82c939347f83f75c307a218d7f61
ToxValDB_EPA_TSCA_8e 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EPA_TSCA_8e LEL =500 mg/kg bw/day Rat oral subchronic; 3 months subchronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21178_Combined.pdf; TOXICOLOGICAL_EFFECT=decreased sperm motility, decreased total sperm counts in the cauda epiddiymides, increased number of abnormal sperms in the cauda epididymidis, significantly decreased absolute weight of epididymides, minimal to moderate segment ductal atrophy in left epididymis, minimal to slight segmental oligospermia, significantly decreased absolute and relative weight of cauda epididymis; STUDY_GROUP=EPA TSCA 8e:15956590:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_78e0741c53ee6588d47d81ea374d1413
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.88 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15629856:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05ff3471ce8a3f77db5407b103a7e319
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 9PA5V6656V UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9PA5V6656V"}
openFDA substances FDA UNII substance identifier 9PA5V6656V UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9PA5V6656V"}
openFDA substances FDA UNII substance identifier 9PA5V6656V UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9PA5V6656V"}
openFDA substances FDA UNII substance identifier 9PA5V6656V UNII - - - chemical {"approval_status":null,"molecular_formula":"C8H8O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9PA5V6656V"}