Is Anisaldehyde (p-Methoxybenzaldehyde) safe in cosmetics?
Anisaldehyde (p-Methoxybenzaldehyde) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Anisaldehyde (p-Methoxybenzaldehyde)
Also known as: 4-Anisaldehyde, p-Anisaldehyde, Caswell No. 051E, EINECS 204-602-6, FEMA No. 2670 (+2 more)
INCI: ANISALDEHYDE
Anisaldehyde (p-Methoxybenzaldehyde) (CAS 123-11-5) is a cosmetic cosmetic ingredient functioning as Perfuming, Flavoring. NOAEL 20 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 123-11-5 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming, Flavoring
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS (#2670); FDA permitted in cosmetics; RIFM safety assessment confirms safe use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Anisaldehyde (p-Methoxybenzaldehyde).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Anisaldehyde (p-Methoxybenzaldehyde) across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
9 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LEL | =500 mg/kg-day | Rat | oral | subchronic | EPA TSCA 8e |
| LEL | =500 mg/kg-day | Rat | oral | subchronic | EPA TSCA 8e |
| NOAEL | =20 mg/kg-day | Rat | oral | subchronic | EFSA |
| LOEL | =50 mg/kg-day | Mouse | injection | acute | ECOTOX |
| NOEL | =50 mg/kg-day | Mouse | injection | acute | ECOTOX |
| LD50 | =1260 mg/kg | Guinea Pig | oral | - | ChemIDplus |
| LD50 | =1859 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >5000 mg/kg | Rabbit | dermal | - | ChemIDplus |
| LD50 | =1510 mg/kg | Rat | oral | - | ChemIDplus |
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 111 | 1 | 4724 | - | - |
| HRIPT | 109 | 1 | 6496 | - | - |
| HRIPT | 102 | 0 | 3543 | 3543 | non-sensitizer |
| HRIPT | 109 | 0 | 2363 | 2363 | non-sensitizer |
| HMT | - | 0 | 6480 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Preservative
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Anisaldehyde (p-Methoxybenzaldehyde).
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Anisaldehyde (p-Methoxybenzaldehyde) by CAS number or substance name.
Studies
9
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
1400 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-Anisaldehyde
p-Anisaldehyde
Caswell No. 051E
EINECS 204-602-6
FEMA No. 2670
Formylanisole, p-
UNII-9PA5V6656V
Chemical Function
Preservative
Fragrance
Deodorizer
Flavouring and nutrient
Regulatory Lists
Europe
inert_ingredient; non_food_use; Pesticides
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
Europe; nondetect; Personal care - sexual wellness
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ANISALDEHYDE
ChEMBL ID
CHEMBL161598
Frequently Asked Questions
Is Anisaldehyde (p-Methoxybenzaldehyde) allowed in the EU?
Anisaldehyde (p-Methoxybenzaldehyde) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Anisaldehyde (p-Methoxybenzaldehyde) do in cosmetics?
Anisaldehyde (p-Methoxybenzaldehyde) functions as: Perfuming, Flavoring. It is classified as a cosmetic ingredient in our database. CAS number: 123-11-5.
Is Anisaldehyde (p-Methoxybenzaldehyde) used outside cosmetics?
Anisaldehyde (p-Methoxybenzaldehyde) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Anisaldehyde (p-Methoxybenzaldehyde) compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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