Is Apigenin-7-Glucoside safe in cosmetics?
Apigenin-7-Glucoside has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Apigenin-7-Glucoside
Also known as: 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-, Cosmosiin, Apigetrin, EINECS 209-430-5
INCI: APIGENIN-7-GLUCOSIDE
Apigenin-7-Glucoside (CAS 578-74-5) is a cosmetic cosmetic ingredient functioning as antioxidant, skin conditioning, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
antioxidant, skin conditioning, anti-inflammatory
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
InChIKey
KMOUJOKENFFTPU-QNDFHXLGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not independently regulated as an OTC drug; used as a cosmetic active. No specific FDA restrictions for topical use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Apigenin-7-Glucoside.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Apigenin-7-Glucoside — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
flavonoid
glycoside
antioxidant-active
anti-inflammatory
Known Synonyms
4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
Cosmosiin
Apigetrin
EINECS 209-430-5
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
APIGETRIN
ChEMBL ID
CHEMBL487017
Frequently Asked Questions
Is Apigenin-7-Glucoside allowed in the EU?
Apigenin-7-Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Apigenin-7-Glucoside do in cosmetics?
Apigenin-7-Glucoside functions as: antioxidant, skin conditioning, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 578-74-5.
Is Apigenin-7-Glucoside used outside cosmetics?
Apigenin-7-Glucoside also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Apigenin-7-Glucoside compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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