Good Cosmetic Ingredient

Apigenin-7-Glucoside

INCI: APIGENIN-7-GLUCOSIDE

CAS Number
578-74-5
Function
antioxidant, skin conditioning, anti-inflammatory
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not independently regulated as an OTC drug; used as a cosmetic active. No specific FDA restrictions for topical use.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

A flavonoid glycoside with significant antioxidant, anti-inflammatory, and ROS-scavenging activity that supports skin barrier function and may alleviate acne, psoriasis, and atopic dermatitis. Well-tolerated with scientific evidence and long history in botanical medicine.

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Concern Level: Low

Regulatory Flags

flavonoid glycoside antioxidant-active anti-inflammatory

Frequently Asked Questions

Is Apigenin-7-Glucoside safe in cosmetics?

A flavonoid glycoside with significant antioxidant, anti-inflammatory, and ROS-scavenging activity that supports skin barrier function and may alleviate acne, psoriasis, and atopic dermatitis. Well-tolerated with scientific evidence and long history in botanical medicine. The EU classifies Apigenin-7-Glucoside as "permitted". Safety rating: GOOD.

Is Apigenin-7-Glucoside allowed in the EU?

Apigenin-7-Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Apigenin-7-Glucoside do in cosmetics?

Apigenin-7-Glucoside functions as: antioxidant, skin conditioning, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 578-74-5.

What is the Margin of Safety for Apigenin-7-Glucoside?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Apigenin-7-Glucoside compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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