Is Ascorbyl Palmitate safe in cosmetics?
Ascorbyl Palmitate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Antioxidant
Ascorbyl Palmitate
INCI: ASCORBYL PALMITATE
Ascorbyl Palmitate (CAS 137-66-6) is a cosmetic antioxidant functioning as Lipophilic antioxidant; ester of ascorbic acid and palmitic acid; product. EU Regulation 1223/2009 status: permitted, max 1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 137-66-6 →
Auto-generated CPSR Part A draft with source citations
Function
Lipophilic antioxidant; ester of ascorbic acid and palmitic acid; product stabiliser; skin-conditioning agent; converted to ascorbic acid after ester cleavage by skin esterases
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
EU Max Conc.
1%
US US Status
permitted
US Notes
FDA GRAS for food use as antioxidant preservative. No specific cosmetic concentration limits. Widely used in lipid-based formulations and oil-phase stabilisation. CIR assessed safe as used.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ascorbyl Palmitate.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Ascorbyl Palmitate.
Regulatory Flags
antioxidant
lipophilic
vitamin-c-derivative
oil-phase-compatible
stable-ester
product-stabiliser
synergistic-with-vitamin-e
gras
cir-reviewed
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ASCORBYL PALMITATE
ChEMBL ID
CHEMBL220190
Max Phase
-1
Frequently Asked Questions
Is Ascorbyl Palmitate allowed in the EU?
Ascorbyl Palmitate EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Ascorbyl Palmitate do in cosmetics?
Ascorbyl Palmitate functions as: Lipophilic antioxidant; ester of ascorbic acid and palmitic acid; product stabiliser; skin-conditioning agent; converted to ascorbic acid after ester cleavage by skin esterases. It is classified as a Antioxidant in our database. CAS number: 137-66-6.
Is Ascorbyl Palmitate used outside cosmetics?
Ascorbyl Palmitate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ascorbyl Palmitate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is Ascorbyl Palmitate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Ascorbyl Palmitate in your formulation.