NOAEL Studies Cosmetic Ingredient

Basic Blue 124 NOAEL Studies

INCI: BASIC BLUE 124

CAS: 67846-56-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =10 mg/kg bw/day rat oral 28-day repeated dose toxicity Ref: NOTOX B, p.32
SCCS Opinion NOAEL =3 mg/kg bw/day rat oral sub-acute repeated dose toxicity Ref: NOTOX B, p.35
SCCS Opinion NOAEL =12 mg/kg bw/day rat oral developmental developmental toxicity p.56
SCCS Opinion NOAEL =0.00032 mg/kg bw rat oral 90-day dermal absorption p.57
SCCS Opinion NOAEL =3 mg/kg bw/d rat oral 90-day dermal absorption p.57
SCCS Opinion NOAEL =1.5 mg/kg bw/d rat oral 90-day dermal absorption p.57
Regulatory source 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption =0.00032 mg/kg bw rat oral 90-day dermal absorption p.57
Regulatory source dermal absorption =3 mg/kg bw/d rat oral 90-day dermal absorption p.57
Regulatory source dermal absorption =1.5 mg/kg bw/d rat oral 90-day dermal absorption p.57
Regulatory source developmental toxicity 12 mg/kg bw/day rat oral developmental developmental toxicity p.56
Regulatory source genotoxicity 3 mg/kg bw/day - - Chronic genotoxicity p.40
Regulatory source genotoxicity 3 mg/kg bw/day - - - genotoxicity p.59
Regulatory source repeated dose toxicity 10 mg/kg bw/day rat oral 28-day repeated dose toxicity p.32
Regulatory source repeated dose toxicity 3 mg/kg bw/day rat oral sub-acute repeated dose toxicity p.35
Regulatory source repeated dose toxicity 3 mg/kg bw/day rat oral subchronic repeated dose toxicity p.39
Regulatory source reproductive toxicity 3 mg/kg bw/day rat - developmental reproductive toxicity p.53