NOAEL Studies
Cosmetic Ingredient
Basic Blue 99 NOAEL Studies
INCI: BASIC BLUE 99
CAS: 68123-13-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
SCCS Opinion 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =62.8 | % | - | - | - | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =74 | - | - | dermal | - | dermal absorption | p.51 |
| SCCS Opinion | NOAEL | =200 | mg/kg | - | - | - | NOAEL study | p.48 |
ECHA 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab36e4b0a7c65d1b9475; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17371/7/9/2?documentUUID=c84a52de-1d48-42ef-8efe-1f0b8e890562; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios|P0: reproductive function (oestrous cycle); TOXICOLOGICAL_EFFECT_CATEGORY=organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15857642:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a189213568b06af84c0784eccab0c77 |
| ECHA | NOEL | =50 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1be8de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17371/7/9/3?documentUUID=c84a52de-1d48-42ef-8efe-1f0b8e890562; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15821060:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6eb065b2e6eaedf51395b501a8f8f18 |
| ECHA | NOEL | =500 | ppm | Mouse | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea5e4b0a7c65d1ca4f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17371/7/6/2?documentUUID=c84a52de-1d48-42ef-8efe-1f0b8e890562; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID:15833164:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7973504cb9fa3d10378d161b0af7d16 |
| ECHA | NOEL | >=180 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea5e4b0a7c65d1ca4fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17371/7/6/2?documentUUID=c84a52de-1d48-42ef-8efe-1f0b8e890562; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846870_15846871:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_725b49c327bdae26529cd08190e62dfa |
| ECHA | NOEL | <=360 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaea5e4b0a7c65d1ca4fa; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17371/7/6/2?documentUUID=c84a52de-1d48-42ef-8efe-1f0b8e890562; YEAR=2015; ORIGINAL_YEAR=2015; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15846870_15846871:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25415c5719b2b3d3c26d88499fb9aa92 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | P0U7VBC51E | UNII | - | - | - | chemical | - |