NOAEL Studies Cosmetic Ingredient

Basic Brown 16 NOAEL Studies

INCI: BASIC BROWN 16

CAS: 26381-41-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 150 mg/kg bw/day rat oral 13 week Subchronic SCCS; Potokar, M., et al. (1985) Arianor Mahogany. 90-Tage-Test nach wiederholter oralerVerabreichung an Ratten. Institut für Toxikologie, Henkel KGaA, Düsseldorf, Germany.Archive code at Henkel KGaA, Düsseldorf: TBD 850004
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 13 week Subchronic SCCS; Potokar, M., et al. (1985) Arianor Mahogany. 90-Tage-Test nach wiederholter oralerVerabreichung an Ratten. Institut für Toxikologie, Henkel KGaA, Düsseldorf, Germany.Archive code at Henkel KGaA, Düsseldorf: TBD 850004
SCCNFP Opinion 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCNFP Opinion NOAEL =50 mg/kg rabbit dermal Sub-chronic repeated dose toxicity Ref. : 7 2, p.7
SCCNFP Opinion NOAEL >94 % human dermal - dermal absorption Ref. : 12 2, p.13
SCCS Opinion 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =50 % - - 90-day NOAEL study Ref: 1 Comment The Purity by NMR = 65, p.8
SCCS Opinion NOAEL =65.7 % - - Chronic genotoxicity p.16
SCCS Opinion NOAEL =90 mg/kg rat - - developmental toxicity p.21
SCCS Opinion NOAEL =50 mg/kg bw/day rat oral 90-day carcinogenicity p.22
SCCS Opinion NOAEL =33 mg/kg bw/day rat oral 90-day NOAEL study p.22
SCCS Opinion NOAEL =8 - - - 90-day NOAEL study p.8
SCCS Opinion NOAEL =3.1 - - - - NOAEL study p.8
SCCS Opinion NOAEL =7 - - - - NOAEL study p.8
SCCS Opinion NOAEL =0.5 % - - - NOAEL study p.8
SCCS Opinion NOAEL =1.2 % - - - NOAEL study p.8
SCCS Opinion NOAEL =6024 - - - - NOAEL study p.8
SCCS Opinion NOAEL =89.1 % - - - NOAEL study p.8
SCCS Opinion NOAEL =100 - - - - NOAEL study p.8
SCCS Opinion NOAEL =10 - - - - NOAEL study p.8
SCCS Opinion NOAEL =1.66 - - - - NOAEL study p.8
SCCS Opinion NOAEL =169 - - - - NOAEL study p.8
SCCS Opinion NOAEL =90 mg/kg bw/day rat - - reproductive toxicity p.24
SCCS Opinion NOAEL =0.095 mg/kg bw rat oral 90-day dermal absorption p.25
SCCS Opinion NOAEL =33 mg/kg bw/d - oral - irritation p.26
SCCS Opinion NOAEL =59 mg/kg bw/d - oral - irritation p.26
Regulatory source 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption >94 % human dermal - dermal absorption p.13
Regulatory source repeated dose toxicity 50 mg/kg rabbit dermal Sub-chronic repeated dose toxicity p.7
Regulatory source - 50 % - - 90-day - p.8
Regulatory source - 65.7 % human - - - p.22
Regulatory source - 33 mg/kg bw/day rat oral 90-day - p.22
Regulatory source - 8 - - - 90-day - p.8
Regulatory source - 3.1 - - - - - p.8
Regulatory source - 7 - - - - - p.8
Regulatory source - 0.5 % - - - - p.8
Regulatory source - 1.2 % - - - - p.8
Regulatory source - 6024 - - - - - p.8
Regulatory source - =89.1 % - - - - p.8
Regulatory source - =50 % - - - - p.8
Regulatory source - >100 - - - - - p.8
Regulatory source - 10 - - - - - p.8
Regulatory source - 50 - - - - - p.8
Regulatory source - 1.66 - - - - - p.8
Regulatory source - 169 - - - - - p.8
Regulatory source carcinogenicity 50 mg/kg bw/day rat oral 90-day carcinogenicity p.22
Regulatory source developmental toxicity 90 mg/kg rat - - developmental toxicity p.21
Regulatory source genotoxicity 65.7 % - - Chronic genotoxicity p.16
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier QEJ5GK0TG1 UNII - - - chemical -