Basic Brown 16
INCI: BASIC BROWN 16
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Basic Brown 16. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| LOAEL | 150 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 33 mg/kg bw/day | oral | - | - | SCCS_PDF_extraction |
| NOAEL | 33 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 59 mg/kg bw/day | oral | - | reproductive | SCCS_PDF_extraction |
| NOAEL | 0.095 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 50 mg/kg bw/day | oral | rat | subchronic | SCCS_PDF_extraction |
| NOAEL | 59 mg/kg bw/day | - | - | - | SCCS_PDF_extraction |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Sensitization Profile
Contact sensitization data for Basic Brown 16 based on clinical patch test studies and IFRA standards.
Source: SCCS; IVDK
Expert Verdict
Mutagenic with positive in vitro bacterial gene mutation and mammalian cell assays; contains azo bond with potential aromatic amine release; eye irritant; oral LD50 2-4 g/kg bw.
Regulatory Flags
Frequently Asked Questions
Is Basic Brown 16 safe in cosmetics?
Mutagenic with positive in vitro bacterial gene mutation and mammalian cell assays; contains azo bond with potential aromatic amine release; eye irritant; oral LD50 2-4 g/kg bw. The EU classifies Basic Brown 16 as "prohibited". Safety rating: POOR. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Is Basic Brown 16 allowed in the EU?
Basic Brown 16 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Basic Brown 16 do in cosmetics?
Basic Brown 16 functions as: Hair colorant (direct, non-oxidative azo dye). It is classified as a cosmetic ingredient in our database. CAS number: 26381-41-9.
What is the Margin of Safety for Basic Brown 16?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Basic Brown 16?
The NOAEL (No Observed Adverse Effect Level) for Basic Brown 16 is 50 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Basic Brown 16 compliance across multiple jurisdictions:
Related Ingredients
Is Basic Brown 16 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Basic Brown 16 in your formulation.