NOAEL Studies
Cosmetic Ingredient
Behenamidopropyl Dimethylamine NOAEL Studies
INCI: BEHENAMIDOPROPYL DIMETHYLAMINE
CAS: 60270-33-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
CIR_vision_codex 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| CIR_vision_codex | NOAEL | =5 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_004"} |
| CIR_vision_codex | NOAEL | =5 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_004"} |
| CIR_vision_codex | NOAEL | =5 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_004"} |
| CIR_vision_codex | NOAEL | =5 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_004"} |
| CIR_vision_codex | NOAEL | >10 | % | rat | oral | 2 weeks | developmental toxicity | {"citation":"10; 30; 70","dose":"The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...","effect":"kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_001"} |
| CIR_vision_codex | NOAEL | >10 | % | rat | oral | 2 weeks | developmental toxicity | {"citation":"10; 30; 70","dose":"The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...","effect":"kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_001"} |
| CIR_vision_codex | NOAEL | >10 | % | rat | oral | 2 weeks | developmental toxicity | {"citation":"10; 30; 70","dose":"The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...","effect":"kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_001"} |
| CIR_vision_codex | NOAEL | >10 | % | rat | oral | 2 weeks | developmental toxicity | {"citation":"10; 30; 70","dose":"The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...","effect":"kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_001"} |
| CIR_vision_codex | NOAEL | =70 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"200; 70; 2","dose":"n sites were noted in the 200 mg/kg dose group females.","effect":"n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_002"} |
| CIR_vision_codex | NOAEL | =70 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"200; 70; 2","dose":"n sites were noted in the 200 mg/kg dose group females.","effect":"n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_002"} |
| CIR_vision_codex | NOAEL | =70 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"200; 70; 2","dose":"n sites were noted in the 200 mg/kg dose group females.","effect":"n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_002"} |
| CIR_vision_codex | NOAEL | =70 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"200; 70; 2","dose":"n sites were noted in the 200 mg/kg dose group females.","effect":"n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_002"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_005"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_005"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_005"} |
| CIR_vision_codex | NOAEL | =100 | mg/kg body weight | rabbit | oral | - | developmental toxicity | {"citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,","page":13,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_005"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"70; 200; 2","dose":"in the 70 and 200 mg/kg dose groups.","effect":"in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_003"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"70; 200; 2","dose":"in the 70 and 200 mg/kg dose groups.","effect":"in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_003"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"70; 200; 2","dose":"in the 70 and 200 mg/kg dose groups.","effect":"in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_003"} |
| CIR_vision_codex | NOAEL | =200 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | {"citation":"70; 200; 2","dose":"in the 70 and 200 mg/kg dose groups.","effect":"in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...","page":12,"pdf":"PRS616.pdf","row_type":"noael_study","study_id":"PRS616_noael_003"} |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =2.96 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631347:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6ab326590892f53fe9fc0da6223cb55 |
UnifiedCodex:CIR:beta.noael_studies 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 5 | mg/kg body weight | rabbit | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS616; REPORT_TITLE=Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Christina L. Burnett1, Ivan Boyer2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks, Jr3, Ronal; OPINION_NUMBER=PRS616; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=December 2010; VALUE_TEXT=5; DOSE=The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...; EFFECT=The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat; CITATION=7; 18; 5; CITATION_NUMBERS=[7,18,5]; REFERENCE=7; 18; 5; DETAILS_JSON={"cas_number":"60270-33-9","citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","duration":"","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plat","endpoint":"developmental toxicity","ingredient":"Fatty Acid Amidopropyl Dimethylamines","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"5","page":13,"route":"oral","species":"rabbit","study_id":"PRS616_noael_004"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 10 | % | rat | oral | 2 weeks | developmental toxicity | SOURCE_SUBDIR=PRS616; REPORT_TITLE=Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Christina L. Burnett1, Ivan Boyer2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks, Jr3, Ronal; OPINION_NUMBER=PRS616; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=December 2010; VALUE_TEXT=greater than 10; DOSE=The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...; EFFECT=kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio; CITATION=10; 30; 70; CITATION_NUMBERS=[10,30,70]; REFERENCE=10; 30; 70; DETAILS_JSON={"cas_number":"60270-33-9","citation":"10; 30; 70","dose":"The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% acti...","duration":"2 weeks","effect":"kidney, prostate, and pancreas. The researchers in this study determined the systemic no observed adverse effect level (NOAEL) of stearamidopropyl dimethylamine was greater than 10% wt/vol in 30%/70% ethanol/water (equivalent to 200 mg/kg body weight per day).2 Reproductive and Developmental Toxicity Stearamidopropyl Dimethylamine The effects of stearamidopropyl dimethylamine (100% active ingredient) on reproduction and development were studied in 10 Wistar rats/sex/dose by oral gavage in accordance with OECD guideline 421.2 Dose levels tested were 0, 20, 70, and 200 mg/kg body weight per day at a dose volume of 5 mL/kg body weight. Parental males were exposed to the test material 2 weeks prior to mating, during mating, and up to study termina- tio","endpoint":"developmental toxicity","ingredient":"Fatty Acid Amidopropyl Dimethylamines","loael_value":"","noael_unit":"%","noael_value":"greater than 10","page":12,"route":"oral","species":"rat","study_id":"PRS616_noael_001"} |
| UnifiedCodex:CIR:beta.noael_studies | developmental toxicity | 100 | mg/kg body weight | rabbit | oral | - | developmental toxicity | SOURCE_SUBDIR=PRS616; REPORT_TITLE=Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Christina L. Burnett1, Ivan Boyer2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks, Jr3, Ronal; OPINION_NUMBER=PRS616; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=December 2010; VALUE_TEXT=100; DOSE=The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...; EFFECT=The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,; CITATION=7; 18; 5; CITATION_NUMBERS=[7,18,5]; REFERENCE=7; 18; 5; DETAILS_JSON={"cas_number":"60270-33-9","citation":"7; 18; 5","dose":"The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dim...","duration":"","effect":"The researchers concluded that dermal application of stear- amidopropyl dimethylamine in rabbits during gestation days 7 through 18 did not produce evidence for developmental toxi- city. The maternal no observed effect level (NOEL) was deter- mined to be 5 mg/kg body weight per day, the maternal NOAEL was determined to be100 mg/kg body weight per day based on variations in body weight and feed-consumption data, and the developmental NOAEL was determined to be 200 mg/ kg body weight per day in this study.2 Genotoxicity Stearamidopropyl Dimethylamine The mutagenic potential of 85% stearamidopropyl dimethyla- mine was studied in reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 and Escherichia coli strain WP2 uvrA, with and without S9 meta- bolic activation.31 The test concentrations ranged from 5 to 5,000 mg/plate. The positive controls were 2-nitrofluorene, 9- aminoacridine, sodium azide,","endpoint":"developmental toxicity","ingredient":"Fatty Acid Amidopropyl Dimethylamines","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"100","page":13,"route":"oral","species":"rabbit","study_id":"PRS616_noael_005"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 70 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | SOURCE_SUBDIR=PRS616; REPORT_TITLE=Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Christina L. Burnett1, Ivan Boyer2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks, Jr3, Ronal; OPINION_NUMBER=PRS616; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=December 2010; VALUE_TEXT=70; DOSE=n sites were noted in the 200 mg/kg dose group females.; EFFECT=n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...; CITATION=200; 70; 2; CITATION_NUMBERS=[200,70,2]; REFERENCE=200; 70; 2; DETAILS_JSON={"cas_number":"60270-33-9","citation":"200; 70; 2","dose":"n sites were noted in the 200 mg/kg dose group females.","duration":"90-day","effect":"n sites were noted in the 200 mg/kg dose group females. A statistically significant lower number of live pups was noted in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a...","endpoint":"repeated dose toxicity","ingredient":"Fatty Acid Amidopropyl Dimethylamines","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"70","page":12,"route":"dermal","species":"rabbit","study_id":"PRS616_noael_002"} |
| UnifiedCodex:CIR:beta.noael_studies | repeated dose toxicity | 200 | mg/kg body weight | rabbit | dermal | 90-day | repeated dose toxicity | SOURCE_SUBDIR=PRS616; REPORT_TITLE=Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics Christina L. Burnett1, Ivan Boyer2, Wilma F. Bergfeld3, Donald V. Belsito3, Ronald A. Hill3, Curtis D. Klaassen3, Daniel C. Liebler3, James G. Marks, Jr3, Ronal; OPINION_NUMBER=PRS616; COMMITTEE=Cosmetic Ingredient Review Expert Panel; REPORT_DATE=December 2010; VALUE_TEXT=200; DOSE=in the 70 and 200 mg/kg dose groups.; EFFECT=in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...; CITATION=70; 200; 2; CITATION_NUMBERS=[70,200,2]; REFERENCE=70; 200; 2; DETAILS_JSON={"cas_number":"60270-33-9","citation":"70; 200; 2","dose":"in the 70 and 200 mg/kg dose groups.","duration":"90-day","effect":"in the 70 and 200 mg/kg dose groups. No other treatment-related changes were noted in any of the remaining reproductive parameters investigated in this study (ie, mating, fertility and conception indices and precoital time, testes and epididymides weights, spermatogenic staging profiles). Based on the results of this study on stearamidopropyl dimethylamine, the researchers determined the paternal NOAEL to be 70 mg/kg body weight per day, the maternal NOAEL to be 70 mg/kg body weight per day, and the developmental NOAEL to be 200 mg/kg body weight per day.2 In the dermal 90-day repeated dose toxicity study in rabbits described earlier, no treatment-related findings concerning the reproductive organs were observed.2 The dermal developmen- tal toxicity potential of stearamidopropyl dimethylamine was studied in 80 artificially inseminated New Zealand White rab- bits.2 Groups of 20 rabbits received the test material at 0, 5, 100, or 200 mg/kg body weight per day at a dose volume of 2 mL/kg body weight during days 7 through 18 of gestation. The test material was applied to the clipped b...","endpoint":"repeated dose toxicity","ingredient":"Fatty Acid Amidopropyl Dimethylamines","loael_value":"","noael_unit":"mg/kg body weight","noael_value":"200","page":12,"route":"dermal","species":"rabbit","study_id":"PRS616_noael_003"} |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | X4O854526J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C27H56N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4O854526J"} |
| openFDA substances | FDA UNII substance identifier | X4O854526J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C27H56N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4O854526J"} |
| openFDA substances | FDA UNII substance identifier | X4O854526J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C27H56N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4O854526J"} |
| openFDA substances | FDA UNII substance identifier | X4O854526J | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C27H56N2O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"X4O854526J"} |