NOAEL Studies
Cosmetic Ingredient
Benzimidazole NOAEL Studies
INCI: BENZIMIDAZOLE
CAS: 51-17-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 27 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 53 | mg/kg bw/day | rat | 2207 | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=74b5a425-b7dd-46da-8cc2-d666d84576cf_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=74b5a425-b7dd-46da-8cc2-d666d84576cf/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=reproductive performance; key_result=false; entry_uuid=4e7966e6-5a11-420b-92f5-21ea1c0c898a |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=5688626d-a4a0-40cc-a110-c7d1618d91df_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=5688626d-a4a0-40cc-a110-c7d1618d91df/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=behaviour (functional findings); key_result=false; entry_uuid=5c09db20-f25a-4ea8-bab4-e05e8545ed20 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=20fa58ee-1c8b-4823-b7cf-5dce37302c3f_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=20fa58ee-1c8b-4823-b7cf-5dce37302c3f/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=clinical signs; key_result=false; entry_uuid=a6566c2d-a597-4d28-95b8-77ff975fe994 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 178 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=750a2f3c-0adb-43f2-a04f-52f2ed75cc1c |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 146.3 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=b30b09af-832b-4aa9-bc2b-f4f64cf25e19 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.176 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ed3a7cce-41df-49bc-b35a-911517eb36d7_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ed3a7cce-41df-49bc-b35a-911517eb36d7/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=3eb4d135-b989-46d7-a187-1f5457d12945 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.335 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ece09140-986a-48e6-8db7-0b092a2bb245_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ece09140-986a-48e6-8db7-0b092a2bb245/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=930e3c23-98a4-45fa-831e-c9640655b419 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.409 | mg/kg bw/day | rat | - | - | developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=aa42aedd-e590-4c26-9998-b3be95b19a79_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=aa42aedd-e590-4c26-9998-b3be95b19a79/788e8431-4719-45e8-a525-838af5c21683; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=be5ab3dc-3fef-40a4-acf3-827568035360 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.57.6 | mg/kg bw/day | - | - | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=48d9405a-8434-468d-80d2-f14bfc4163aa_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=48d9405a-8434-468d-80d2-f14bfc4163aa/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=03fb4b72-0c2d-488f-a2b5-b4c1c5e3319a |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 53 | mg/kg bw/day | rat | 2207 | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=74b5a425-b7dd-46da-8cc2-d666d84576cf_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=74b5a425-b7dd-46da-8cc2-d666d84576cf/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=reproductive performance; key_result=false; entry_uuid=4e7966e6-5a11-420b-92f5-21ea1c0c898a |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=5688626d-a4a0-40cc-a110-c7d1618d91df_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=5688626d-a4a0-40cc-a110-c7d1618d91df/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=behaviour (functional findings); key_result=false; entry_uuid=5c09db20-f25a-4ea8-bab4-e05e8545ed20 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=20fa58ee-1c8b-4823-b7cf-5dce37302c3f_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=20fa58ee-1c8b-4823-b7cf-5dce37302c3f/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=clinical signs; key_result=false; entry_uuid=a6566c2d-a597-4d28-95b8-77ff975fe994 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 178 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=750a2f3c-0adb-43f2-a04f-52f2ed75cc1c |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 146.3 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=b30b09af-832b-4aa9-bc2b-f4f64cf25e19 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.176 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ed3a7cce-41df-49bc-b35a-911517eb36d7_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ed3a7cce-41df-49bc-b35a-911517eb36d7/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=3eb4d135-b989-46d7-a187-1f5457d12945 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.335 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ece09140-986a-48e6-8db7-0b092a2bb245_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ece09140-986a-48e6-8db7-0b092a2bb245/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=930e3c23-98a4-45fa-831e-c9640655b419 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.409 | mg/kg bw/day | rat | - | - | developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=aa42aedd-e590-4c26-9998-b3be95b19a79_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=aa42aedd-e590-4c26-9998-b3be95b19a79/788e8431-4719-45e8-a525-838af5c21683; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=be5ab3dc-3fef-40a4-acf3-827568035360 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.57.6 | mg/kg bw/day | - | - | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=48d9405a-8434-468d-80d2-f14bfc4163aa_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=48d9405a-8434-468d-80d2-f14bfc4163aa/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=03fb4b72-0c2d-488f-a2b5-b4c1c5e3319a |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 53 | mg/kg bw/day | rat | 2207 | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=74b5a425-b7dd-46da-8cc2-d666d84576cf_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=74b5a425-b7dd-46da-8cc2-d666d84576cf/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2011; basis=reproductive performance; key_result=false; entry_uuid=4e7966e6-5a11-420b-92f5-21ea1c0c898a |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 250 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=5688626d-a4a0-40cc-a110-c7d1618d91df_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=5688626d-a4a0-40cc-a110-c7d1618d91df/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=behaviour (functional findings); key_result=false; entry_uuid=5c09db20-f25a-4ea8-bab4-e05e8545ed20 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=20fa58ee-1c8b-4823-b7cf-5dce37302c3f_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=20fa58ee-1c8b-4823-b7cf-5dce37302c3f/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2018; ReportDate=2018-03-16; basis=clinical signs; key_result=false; entry_uuid=a6566c2d-a597-4d28-95b8-77ff975fe994 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 178 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=750a2f3c-0adb-43f2-a04f-52f2ed75cc1c |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 146.3 | mg/kg bw/day | mouse | oral: feed | - | reproductive toxicity, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=2f9d3aa7-c2cc-4a91-a166-a9bd81d2872a/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2001; basis=other:; key_result=false; entry_uuid=b30b09af-832b-4aa9-bc2b-f4f64cf25e19 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.176 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ed3a7cce-41df-49bc-b35a-911517eb36d7_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ed3a7cce-41df-49bc-b35a-911517eb36d7/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=3eb4d135-b989-46d7-a187-1f5457d12945 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.335 | mg/kg bw/day | rat | - | - | repeated dose toxicity: oral, other | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=ece09140-986a-48e6-8db7-0b092a2bb245_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=ece09140-986a-48e6-8db7-0b092a2bb245/788e8431-4719-45e8-a525-838af5c21683; document_subtype=RepeatedDoseToxicityOral; basis=other:; key_result=false; entry_uuid=930e3c23-98a4-45fa-831e-c9640655b419 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.409 | mg/kg bw/day | rat | - | - | developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=aa42aedd-e590-4c26-9998-b3be95b19a79_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=aa42aedd-e590-4c26-9998-b3be95b19a79/788e8431-4719-45e8-a525-838af5c21683; document_subtype=DevelopmentalToxicityTeratogenicity; basis=other:; key_result=false; entry_uuid=be5ab3dc-3fef-40a4-acf3-827568035360 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | ca.57.6 | mg/kg bw/day | - | - | - | screening for reproductive / developmental toxicity | dossier=788e8431-4719-45e8-a525-838af5c21683.i6z; document=48d9405a-8434-468d-80d2-f14bfc4163aa_788e8431-4719-45e8-a525-838af5c21683.i6d; document_key=48d9405a-8434-468d-80d2-f14bfc4163aa/788e8431-4719-45e8-a525-838af5c21683; document_subtype=ToxicityReproduction; basis=other:; key_result=false; entry_uuid=03fb4b72-0c2d-488f-a2b5-b4c1c5e3319a |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =19.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630016_15630017:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_72ab30a2941c7da053e00fc4d57f3f72 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =2.61 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630016_15630017:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e7377feb0efc0aae4046daae319b6b5c |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | E24GX49LD8 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H6N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E24GX49LD8"} |
| openFDA substances | FDA UNII substance identifier | E24GX49LD8 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H6N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E24GX49LD8"} |
| openFDA substances | FDA UNII substance identifier | E24GX49LD8 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H6N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E24GX49LD8"} |
| openFDA substances | FDA UNII substance identifier | E24GX49LD8 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H6N2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"E24GX49LD8"} |