Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Benzimidazole. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 200 other | oral | rat | oral | REACH |
| NOAEL | ca.176 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.335 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Parent heterocycle used mainly as a building block for derivatives such as UV filters like bisoctrizole; limited standalone cosmetic safety data; some in vitro mutagenicity flags for the base compound in non-cosmetic literature.
Frequently Asked Questions
Is Benzimidazole safe in cosmetics?
Parent heterocycle used mainly as a building block for derivatives such as UV filters like bisoctrizole; limited standalone cosmetic safety data; some in vitro mutagenicity flags for the base compound in non-cosmetic literature. The EU classifies Benzimidazole as "prohibited". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Benzimidazole allowed in the EU?
Benzimidazole EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzimidazole do in cosmetics?
Benzimidazole functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 51-17-2.
What is the Margin of Safety for Benzimidazole?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Benzimidazole?
The NOAEL (No Observed Adverse Effect Level) for Benzimidazole is 250 mg/kg bw/day based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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