NOAEL Studies Cosmetic Ingredient

Benzophenone-2 NOAEL Studies

INCI: BENZOPHENONE-2

CAS: 131-55-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE adme parameters 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 19.2 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2176; Record_ID=adme_parameters_709; Data_Type=Measured; DTXSID=DTXSID5041306; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=19.2; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE adme parameters Clint 103 uL/min/10^6 cells Rat - - Measured; httk, Rat Hepatic Intrinsic Clearance sheet=Data; excel_row=2177; Record_ID=adme_parameters_709; Data_Type=Measured; DTXSID=DTXSID5041306; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=103.0; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Black 2021; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE adme parameters Fu 0.0354 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=2175; Record_ID=adme_parameters_709; Data_Type=Measured; DTXSID=DTXSID5041306; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.0354; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 1.75364714262133 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1554; RecordID=ERPathway2016_167; DatasetName=ERPathway2016; DTXSID=DTXSID5041306; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=1.75364714262133; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50 5.992535597 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1548; RecordID=ARPathway2016_52; DatasetName=ARPathway2016; DTXSID=DTXSID5041306; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=5.992535597; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50/EC50/IC50 1323 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13285; Record_ID=endocrine_invitro_4117; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1323; Reported_Response_Unit=nM; Response=1323; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Molina-Molina et al. 2008; 18706922; 10.1016/j.taap.2008.07.017; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50/EC50/IC50 1530 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13358; Record_ID=endocrine_invitro_4131; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=1530; Reported_Response_Unit=nM; Response=1530; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Suzuki et al. 2005; 15694459; 10.1016/j.taap.2004.07.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50/EC50/IC50 2500 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13128; Record_ID=endocrine_invitro_4073; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=2500; Reported_Response_Unit=nM; Response=2500; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50/EC50/IC50 4900 nM - - - In Vitro; AR Transactivation-Antagonist sheet=Data_invitro; excel_row=13127; Record_ID=endocrine_invitro_4072; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=AR Transactivation-Antagonist; Endpoint=AC50/EC50/IC50; Reported_Response=4900; Reported_Response_Unit=nM; Response=4900; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Ermler et al. 2011; 21945941; 10.1016/j.taap.2011.09.005; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine AC50/EC50/IC50 62700 nM - - - In Vitro; AR Transactivation-Agonist sheet=Data_invitro; excel_row=7891; Record_ID=endocrine_invitro_3481; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=AR Transactivation-Agonist; Endpoint=AC50/EC50/IC50; Reported_Response=62700; Reported_Response_Unit=nM; Response=62700; Response_Unit=nM; Reference=Kleinstreuer et al. 2016; 27933809; 10.1021/acs.chemrestox.6b00347|Kunz and Fent 2006; 16911836; 10.1016/j.aquatox.2006.06.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine ACC 0.94227658039805 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1555; RecordID=ERPathway2016_167; DatasetName=ERPathway2016; DTXSID=DTXSID5041306; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=0.94227658039805; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine ACC 10.53998791 uM - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1549; RecordID=ARPathway2016_52; DatasetName=ARPathway2016; DTXSID=DTXSID5041306; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=10.53998791; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine LOEL 200 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=777; Record_ID=endocrine_invivo_55; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=800; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Yamasaki et al. 2003; 12765246; 10.1016/s0378-4274(03)00019-5|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine LOEL 229.8 mg/kg bw/day Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 20; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=784; Record_ID=endocrine_invivo_61; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=229.8; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Crj:CD(SD)IGS; Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=1000.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine LOEL 300 mg/kg bw/day Mouse Subcutaneous Treatment_Duration=7 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=788; Record_ID=endocrine_invivo_63; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=300; Response_Unit=mg/kg/day; Species=Mouse; Reported_Strain=C57BL/6J; Strain=C57BL/6; Sex=Female (ovariectomized); Route=Subcutaneous; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Ohta et al. 2012; 23037998; 10.2131/jts.37.879|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine LOEL 1000 mg/kg bw/day Mouse Oral Treatment_Duration=7 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=6 weeks; Time_Elapsed_Between_Surgery_and_Treatment=2 weeks; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=4 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=779; Record_ID=endocrine_invivo_57; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Uterotrophic-Agonist; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Mouse; Reported_Strain=C57BL/6J; Strain=C57BL/6; Sex=Female (ovariectomized); Route=Oral; Maximum_Dose=1000; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Ohta et al. 2012; 23037998; 10.2131/jts.37.879|Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine Model Score 0 unitless - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1557; RecordID=ERPathway2016_167; DatasetName=ERPathway2016; DTXSID=DTXSID5041306; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine Model Score 0.00909 unitless - - - ARPathway2016; AR Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1551; RecordID=ARPathway2016_52; DatasetName=ARPathway2016; DTXSID=DTXSID5041306; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0.00909; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine Model Score 0.397 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=1556; RecordID=ERPathway2016_167; DatasetName=ERPathway2016; DTXSID=DTXSID5041306; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.397; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine Model Score 0.448 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=1550; RecordID=ARPathway2016_52; DatasetName=ARPathway2016; DTXSID=DTXSID5041306; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.448; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine NOEL 400 mg/kg bw/day Rat Oral Treatment_Duration=10 days; Age_at_First_Dose=PND 56; Age_Ovariectomized_or_Castrated=PND 42; Time_Elapsed_Between_Surgery_and_Treatment=14 days; Time_Elapsed_Between_Last_Dose_and_Necropsy=18 to 36 hours; Number_of_Doses_Tested=6 In Vivo; Hershberger-Agonist sheet=Data_invivo; excel_row=2150; Record_ID=endocrine_invivo_923; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Hershberger-Agonist; Endpoint=NOEL; Response=400; Response_Unit=mg/kg/day; Species=Rat; Reported_Strain=Sprague-Dawley; Strain=Sprague-Dawley; Sex=Male (castrated); Route=Oral; Reference_Hormone=Testosterone propionate; Reference_Hormone_Dose=0.2; Reference_Hormone_Dose_Units=mg/kg/day; Reference_Hormone_Route=Subcutaneous; Additional_Information=Browne et al. 2018 unique record identifier 253; Reference=Yamasaki et al. 2003; 12504345; 10.1016/s0300-483x(02)00445-6|Browne et al. 2018; 30205136; 10.1016/j.reprotox.2018.08.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
NTP ICE endocrine Uterine weight increase vs control 230 % Rat Subcutaneous Treatment_Duration=3 days; Age_at_First_Dose=PND 19; Time_Elapsed_Between_Last_Dose_and_Necropsy=24 hours; Number_of_Doses_Tested=3 In Vivo; Uterotrophic-Agonist sheet=Data_invivo; excel_row=2239; Record_ID=endocrine_invivo_55; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID5041306; Assay=Uterotrophic-Agonist; Endpoint=Uterine weight increase vs control; Response=230; Response_Unit=%; Species=Rat; Reported_Strain=Crj:CD(SD); Strain=Sprague-Dawley; Sex=Female; Route=Subcutaneous; Maximum_Dose=800.0; Maximum_Dose_Units=mg/kg/day; Reference_Hormone=Ethinylestradiol; Reference=Kleinstreuer et al. 2016; 26431337; 10.1289/ehp.1510183; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5041306
SCCS Opinion 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =5 % - oral - NOAEL study p.39
SCCS Opinion NOAEL =7 - - - - NOAEL study p.39
SCCS Opinion NOAEL =620 - - - - NOAEL study p.39
SCCS Opinion NOAEL =1239 mg/kg bw/day rat oral 90-day repeated dose toxicity p.38
ToxValDB Uterotrophic Hershberger DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB Uterotrophic Hershberger DB LEL =100 mg/kg bw/day Rat oral short-term; 5 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713607_15713654:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df5bd405be9bbc0a00c284a08da07e7b
ToxValDB Uterotrophic Hershberger DB LEL =185 mg/kg bw/day Rat oral subchronic; 90 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713398:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1268983598d429ff0f2904f87e422c89
ToxValDB Uterotrophic Hershberger DB LEL =200 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713613_15713641_15714027:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bd8f08fa3a82dfc1469c6aea3460922c
ToxValDB Uterotrophic Hershberger DB LEL =229.784 mg/kg bw/day Rat injection short-term; 3 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713613_15713641_15714027:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8350e0ac2dc271d9c637ee78dd8c3b57
ToxValDB Uterotrophic Hershberger DB LEL =250 mg/kg bw/day Rat oral short-term; 5 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=0; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB_dup_-_15713607_15713654:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd820def9fad4989295fd63e4aee0c8
ToxValDB Uterotrophic Hershberger DB LEL =300 mg/kg bw/day Mouse injection short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713661:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_070ea5d03ccf48a81940796647512fbf
ToxValDB Uterotrophic Hershberger DB LEL =1000 mg/kg bw/day Mouse oral short-term; 7 days uterotrophic LONG_REF=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124 2106, https://doi.org/10.1289/ehp.1510183; TITLE=A Curated Database of Rodent Uterotrophic Bioactivity; AUTHOR=Kleinstreuer et al., A Curated Database of Rodent Uterotrophic Bioactivity, EHP Vol 124; DOI=10.1289/ehp.1510183; GUIDELINE=1; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759abc7e4b0a7c65d37b40c; RECORD_SOURCE_LEVEL=Extraction document; TOXICOLOGICAL_EFFECT=Active; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=Uterotrophic Hershberger DB:15713685:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_982e9c3cfd267df26518c942f48f4560
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier PRR8K3H9VN UNII - - - chemical -